Decanoic acid inhibits mTORC1 activity independent of glucose and insulin signaling.

Adaptor Proteins, Signal Transducing / metabolism Animals Astrocytes / metabolism Cell Cycle Proteins / metabolism Cells, Cultured Decanoic Acids / pharmacology Dictyostelium / drug effects Epilepsy Glucose / metabolism Hippocampus / chemistry Humans Insulin / metabolism Mechanistic Target of Rapamycin Complex 1 / antagonists & inhibitors Peptide Initiation Factors Phosphorylation Rats
Dictyostelium discoideum decanoic acid epilepsy mTOR tuberous sclerosis complex

Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
22 09 2020
Historique:
pubmed: 4 9 2020
medline: 18 11 2020
entrez: 4 9 2020
Statut: ppublish

Résumé

Low-glucose and -insulin conditions, associated with ketogenic diets, can reduce the activity of the mechanistic target of rapamycin complex 1 (mTORC1) signaling pathway, potentially leading to a range of positive medical and health-related effects. Here, we determined whether mTORC1 signaling is also a target for decanoic acid, a key component of the medium-chain triglyceride (MCT) ketogenic diet. Using a tractable model system,

Identifiants

DOI: 10.1073/pnas.2008980117 PMID: 32879008 PMC: PMC7519326
pubmed: 32879008
pii: 2008980117
doi: 10.1073/pnas.2008980117
pmc: PMC7519326
doi:

Substances chimiques

Adaptor Proteins, Signal Transducing 0
Cell Cycle Proteins 0
Decanoic Acids 0
Insulin 0
Peptide Initiation Factors 0
decanoic acid 4G9EDB6V73
Mechanistic Target of Rapamycin Complex 1 EC 2.7.11.1
Glucose IY9XDZ35W2

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

23617-23625

Subventions

Organisme : Biotechnology and Biological Sciences Research Council
Pays : United Kingdom

Informations de copyright

Copyright © 2020 the Author(s). Published by PNAS.

Déclaration de conflit d'intérêts

Competing interest statement: M.C.W. and R.S.B.W. are named inventors on related patents WO2019002435A1, WO2012069790A1, WO2016038379A1, and WO2018189113.

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Auteurs

Eleanor C Warren (EC)

Centre for Biomedical Sciences, Department of Biological Sciences, Royal Holloway University of London, Egham TW20 0EX, United Kingdom.
ORCID: 0000-0001-8802-3407

Stephanie Dooves (S)

Department of Child and Youth Psychiatry, Amsterdam Universitair Medische Centra, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands.
ORCID: 0000-0002-8090-766X

Eleonora Lugarà (E)

Clinical and Experimental Epilepsy UCL, Queen Square Institute of Neurology, University College London, London WC1N 3BG, United Kingdom.
ORCID: 0000-0001-9211-4344

Joseph Damstra-Oddy (J)

Centre for Biomedical Sciences, Department of Biological Sciences, Royal Holloway University of London, Egham TW20 0EX, United Kingdom.

Judith Schaf (J)

Centre for Biomedical Sciences, Department of Biological Sciences, Royal Holloway University of London, Egham TW20 0EX, United Kingdom.
ORCID: 0000-0002-8638-7490

Vivi M Heine (VM)

Department of Child and Youth Psychiatry, Amsterdam Universitair Medische Centra, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands.
Department of Complex Trait Genetics, Centre for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands.
ORCID: 0000-0003-4416-3875

Mathew C Walker (MC)

Clinical and Experimental Epilepsy UCL, Queen Square Institute of Neurology, University College London, London WC1N 3BG, United Kingdom.

Robin S B Williams (RSB)

Centre for Biomedical Sciences, Department of Biological Sciences, Royal Holloway University of London, Egham TW20 0EX, United Kingdom; robin.williams@rhul.ac.uk.
ORCID: 0000-0002-9826-6020

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines adaptatrices de la transduction du signal › Decanoic acid inhibits mTORC1 activity...
questionsmedicales.fr › Eucaryotes › Animaux › Decanoic acid inhibits mTORC1 activity...
questionsmedicales.fr › Cellules › Névroglie › Astrocytes › Decanoic acid inhibits mTORC1 activity...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du cycle cellulaire › Decanoic acid inhibits mTORC1 activity...
questionsmedicales.fr › Cellules › Cellules cultivées › Decanoic acid inhibits mTORC1 activity...
questionsmedicales.fr › Lipides › Acides gras › Acides capriques › Decanoic acid inhibits mTORC1 activity...
questionsmedicales.fr › Eucaryotes › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium › Decanoic acid inhibits mTORC1 activity...
questionsmedicales.fr › Maladies du système nerveux › Maladies du système nerveux central › Encéphalopathies › Épilepsie › Decanoic acid inhibits mTORC1 activity...
questionsmedicales.fr › Glucides › Sucres › Oses › Hexose › Glucose › Decanoic acid inhibits mTORC1 activity...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Hippocampe › Decanoic acid inhibits mTORC1 activity...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Decanoic acid inhibits mTORC1 activity...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Hormones peptidiques › Hormones pancréatiques › Insulines › Insuline › Decanoic acid inhibits mTORC1 activity...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Sérine-thréonine kinases TOR › Complexe-1 cible mécanistique de la rapamycine › Decanoic acid inhibits mTORC1 activity...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines ribosomiques › Facteurs initiation chaîne peptidique › Decanoic acid inhibits mTORC1 activity...
questionsmedicales.fr › Métabolisme › Phosphorylation › Decanoic acid inhibits mTORC1 activity...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Decanoic acid inhibits mTORC1 activity...