Sex-biased patterns shaped the genetic history of Roma.

Asian People / genetics Chromosomes, Human, Y / genetics DNA, Mitochondrial / genetics Ethnicity / genetics Female Founder Effect Gene Flow / genetics Genetic Variation / genetics Genetics, Population Haplotypes / genetics History, Ancient Human Migration Humans Male Roma / genetics Sex Characteristics White People / genetics

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
02 09 2020
Historique:
received: 18 12 2019
accepted: 07 08 2020
entrez: 4 9 2020
pubmed: 4 9 2020
medline: 25 2 2021
Statut: epublish

Résumé

The Roma population is a European ethnic minority characterized by recent and multiple dispersals and founder effects. After their origin in South Asia around 1,500 years ago, they migrated West. In Europe, they diverged into ethnolinguistically distinct migrant groups that spread across the continent. Previous genetic studies based on genome-wide data and uniparental markers detected Roma founder events and West-Eurasian gene flow. However, to the best of our knowledge, it has not been assessed whether these demographic processes have equally affected both sexes in the population. The present study uses the largest and most comprehensive dataset of complete mitochondrial and Y chromosome Roma sequences to unravel the sex-biased patterns that have shaped their genetic history. The results show that the Roma maternal genetic pool carries a higher lineage diversity from South Asia, as opposed to a single paternal South Asian lineage. Nonetheless, the European gene flow events mainly occurred through the maternal lineages; however, a signal of this gene flow is also traceable in the paternal lineages. We also detect a higher female migration rate among European Roma groups. Altogether, these results suggest that sociocultural factors influenced the emergence of sex-biased genetic patterns at global and local scales in the Roma population through time.

Identifiants

DOI: 10.1038/s41598-020-71066-y PMID: 32879340 PMC: PMC7468237
pubmed: 32879340
doi: 10.1038/s41598-020-71066-y
pii: 10.1038/s41598-020-71066-y
pmc: PMC7468237
doi:

Substances chimiques

DNA, Mitochondrial 0

Types de publication

Historical Article Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

14464

Commentaires et corrections

Type : ErratumIn

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Auteurs

C García-Fernández (C)

Institute of Evolutionary Biology (UPF-CSIC), Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona, Spain.

N Font-Porterias (N)

Institute of Evolutionary Biology (UPF-CSIC), Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona, Spain.

V Kučinskas (V)

Department of Human and Medical Genetics, Faculty of Medicine, Biomedical Science Institute, Vilnius University, Vilnius, Lithuania.

E Sukarova-Stefanovska (E)

Research Center for Genetic Engineering and Biotechnology "Georgi D. Efremov", Academy of Sciences and Arts of the Republic of North Macedonia - MASA, Skopje, Republic of North Macedonia.

H Pamjav (H)

Institute of Forensic Genetics, Hungarian Institute for Forensic Sciences, Budapest, Hungary.

H Makukh (H)

Institute of Hereditary Pathology, Ukrainian Academy of Medical Sciences, Lviv, Ukraine.

B Dobon (B)

Institute of Evolutionary Biology (UPF-CSIC), Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona, Spain.

J Bertranpetit (J)

Institute of Evolutionary Biology (UPF-CSIC), Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona, Spain.

M G Netea (MG)

Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, 6525 GA, Nijmegen, the Netherlands.
Department of Human Genetics, University of Medicine and Pharmacy Craiova, Craiova, Romania.
Department for Genomics and Immunoregulation, Life and Medical Sciences Institute (LIMES), University of Bonn, 53115, Bonn, Germany.

F Calafell (F)

Institute of Evolutionary Biology (UPF-CSIC), Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona, Spain. francesc.calafell@upf.edu.

D Comas (D)

Institute of Evolutionary Biology (UPF-CSIC), Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona, Spain. david.comas@upf.edu.

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Classifications MeSH

questionsmedicales.fr › Personnes › Asiatiques › Sex-biased patterns shaped the genetic history of Roma.
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Chromosomes › Chromosomes sexuels › Chromosome Y › Chromosomes Y humains › Sex-biased patterns shaped the genetic history of Roma.
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ADN › ADN mitochondrial › Sex-biased patterns shaped the genetic history of Roma.
questionsmedicales.fr › Caractéristiques de la population › Ethnies › Sex-biased patterns shaped the genetic history of Roma.
questionsmedicales.fr › Phénomènes génétiques › Effet fondateur › Sex-biased patterns shaped the genetic history of Roma.
questionsmedicales.fr › Phénomènes génétiques › Fréquence d'allèle › Flux des gènes › Sex-biased patterns shaped the genetic history of Roma.
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Sex-biased patterns shaped the genetic history of Roma.
questionsmedicales.fr › Disciplines des sciences naturelles › Disciplines des sciences biologiques › Biologie › Génétique › Génétique des populations › Sex-biased patterns shaped the genetic history of Roma.
questionsmedicales.fr › Phénomènes génétiques › Génotype › Haplotypes › Sex-biased patterns shaped the genetic history of Roma.
questionsmedicales.fr › Sciences humaines › Histoire › Histoire ancienne › Sex-biased patterns shaped the genetic history of Roma.
questionsmedicales.fr › Environnement et santé publique › Santé publique › Mesures épidémiologiques › Démographie › Dynamique des populations › Migration humaine › Sex-biased patterns shaped the genetic history of Roma.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Sex-biased patterns shaped the genetic history of Roma.
questionsmedicales.fr › Personnes › Disparités en matière de santé, minorités et populations vulnérables › Tsigane › Sex-biased patterns shaped the genetic history of Roma.
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Caractères sexuels › Sex-biased patterns shaped the genetic history of Roma.
questionsmedicales.fr › Personnes › Blancs › Sex-biased patterns shaped the genetic history of Roma.