Pervasive chromosomal instability and karyotype order in tumour evolution.

Chromosomal Instability / genetics Chromosomes, Human, Pair 11 / genetics Chromosomes, Human, Pair 8 / genetics Clone Cells / metabolism Cyclin E / genetics DNA Copy Number Variations / genetics Evolution, Molecular Female Humans Karyotype Loss of Heterozygosity / genetics Male Mutagenesis Neoplasm Metastasis / genetics Neoplasms / genetics Oncogene Proteins / genetics

Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
11 2020
Historique:
received: 01 04 2019
accepted: 24 06 2020
pubmed: 4 9 2020
medline: 20 2 2021
entrez: 4 9 2020
Statut: ppublish

Résumé

Chromosomal instability in cancer consists of dynamic changes to the number and structure of chromosomes

Identifiants

DOI: 10.1038/s41586-020-2698-6 PMID: 32879494 PMC: PMC7611706
pubmed: 32879494
doi: 10.1038/s41586-020-2698-6
pii: 10.1038/s41586-020-2698-6
pmc: PMC7611706
mid: EMS133948
doi:

Substances chimiques

CCNE1 protein, human 0
Cyclin E 0
Oncogene Proteins 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

126-132

Subventions

Organisme : Cancer Research UK
ID : FC001169
Pays : United Kingdom
Organisme : Cancer Research UK
ID : FC001110
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 214584/Z/18/Z
Pays : United Kingdom
Organisme : Wellcome Trust
ID : FC001169
Pays : United Kingdom
Organisme : NIH HHS
ID : DP5 OD026395
Pays : United States
Organisme : Medical Research Council
ID : MR/P014712/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : FC001202
Pays : United Kingdom
Organisme : NCI NIH HHS
ID : R01 CA256188
Pays : United States
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Wellcome Trust
ID : FC001202
Pays : United Kingdom
Organisme : Cancer Research UK
ID : FC001202
Pays : United Kingdom
Organisme : Medical Research Council
ID : FC001169
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 211179/Z/18/Z
Pays : United Kingdom
Organisme : European Research Council
Pays : International
Organisme : Wellcome Trust
ID : FC010110
Pays : United Kingdom
Organisme : Wellcome Trust
ID : FC001110
Pays : United Kingdom
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : Medical Research Council
ID : MR/L016311/1
Pays : United Kingdom
Organisme : Arthritis Research UK
ID : FC001202
Pays : United Kingdom
Organisme : Medical Research Council
ID : FC001110
Pays : United Kingdom
Organisme : Arthritis Research UK
ID : FC001169
Pays : United Kingdom
Organisme : NCI NIH HHS
ID : R35 CA220481
Pays : United States
Organisme : Medical Research Council
ID : MR/P014712/2
Pays : United Kingdom

Références

Nucleic Acids Res. 2015 Jan;43(Database issue):D805-11
pubmed: 25355519
Nat Genet. 2019 May;51(5):824-834
pubmed: 31036964
Nature. 2018 Jan 25;553(7689):467-472
pubmed: 29342134
Genome Res. 2012 Jun;22(6):993-1005
pubmed: 22456607
BMC Bioinformatics. 2011 Aug 04;12:323
pubmed: 21816040
Mol Biol Cell. 2002 Jun;13(6):1977-2000
pubmed: 12058064
Nat Biotechnol. 2021 Feb;39(2):207-214
pubmed: 32879467
Sci Rep. 2019 Mar 14;9(1):4611
pubmed: 30872650
Nature. 2005 Oct 13;437(7061):1043-7
pubmed: 16222300
Nat Genet. 2015 Mar;47(3):209-16
pubmed: 25665006
N Engl J Med. 2014 Dec 4;371(23):2189-2199
pubmed: 25409260
Cell. 2017 Nov 30;171(6):1259-1271.e11
pubmed: 29107330
Genome Biol. 2011;12(4):R41
pubmed: 21527027
Cell. 2018 Apr 5;173(2):371-385.e18
pubmed: 29625053
N Engl J Med. 2017 Jun 1;376(22):2109-2121
pubmed: 28445112
Proc Natl Acad Sci U S A. 2010 Sep 28;107(39):16910-5
pubmed: 20837533
Nat Genet. 2018 Aug;50(8):1189-1195
pubmed: 30013179
PLoS Med. 2015 Feb 24;12(2):e1001789
pubmed: 25710373
J Clin Oncol. 2013 Nov 1;31(31):3997-4013
pubmed: 24101045
Nat Genet. 2016 Mar;48(3):238-244
pubmed: 26780609
PLoS Comput Biol. 2018 Sep 11;14(9):e1006447
pubmed: 30204765
Cell. 2013 Nov 7;155(4):948-62
pubmed: 24183448
Nat Genet. 2014 Aug;46(8):912-918
pubmed: 25017105
Nature. 2015 Apr 16;520(7547):353-357
pubmed: 25830880
Genome Biol. 2011 Aug 29;12(8):R80
pubmed: 21854607
Cell Rep. 2018 Jun 12;23(11):3366-3380
pubmed: 29898405
PLoS Genet. 2009 Jun;5(6):e1000529
pubmed: 19543373
Cell. 2018 Apr 19;173(3):595-610.e11
pubmed: 29656894
J Thorac Oncol. 2013 Jan;8(1):37-44
pubmed: 23242436
Cell Rep. 2015 Aug 4;12(5):809-20
pubmed: 26212324
Nat Genet. 2020 Mar;52(3):283-293
pubmed: 32139907
Nat Biotechnol. 2020 Jan;38(1):90-96
pubmed: 31685958
Nucleic Acids Res. 2015 Feb 27;43(4):e25
pubmed: 25452340
Genome Res. 2007 Nov;17(11):1665-74
pubmed: 17921354
EMBO Rep. 2012 Jun 01;13(6):528-38
pubmed: 22595889
Nature. 2019 Nov;575(7781):210-216
pubmed: 31645765
Bioinformatics. 2013 Jan 1;29(1):15-21
pubmed: 23104886
Nature. 2017 Mar 2;543(7643):122-125
pubmed: 28178237
Cancer Cell. 2017 Aug 14;32(2):169-184.e7
pubmed: 28810143
Nat Med. 2015 Jul;21(7):751-9
pubmed: 26099045
J Thorac Oncol. 2014 Aug;9(8):1126-39
pubmed: 24942260
Nat Genet. 2013 Oct;45(10):1134-40
pubmed: 24071852
Cancer Cell. 2016 May 9;29(5):751-766
pubmed: 27165746
Nat Genet. 2006 Sep;38(9):1043-8
pubmed: 16921376
Nature. 2017 Apr 26;545(7655):446-451
pubmed: 28445469
Cell. 2018 Apr 19;173(3):611-623.e17
pubmed: 29656891
Elife. 2018 Sep 04;7:
pubmed: 30178746
Cell. 2006 Jun 30;125(7):1269-81
pubmed: 16814714
PLoS Comput Biol. 2014 Apr 17;10(4):e1003535
pubmed: 24743184
Nat Genet. 2020 Apr;52(4):371-377
pubmed: 32203465
Cell. 2012 May 25;149(5):994-1007
pubmed: 22608083
J Pathol. 2013 Aug;230(4):356-64
pubmed: 23716380
Nature. 2019 Mar;567(7749):479-485
pubmed: 30894752
Nat Commun. 2016 Sep 08;7:12817
pubmed: 27605262

Auteurs

Thomas B K Watkins (TBK)

Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.

Emilia L Lim (EL)

Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.
Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.

Marina Petkovic (M)

Berlin Institute for Medical Systems Biology, Max Delbrück Center for Molecular Medicine, Berlin, Germany.
ORCID: 0000-0003-2875-216X

Sergi Elizalde (S)

Department of Mathematics, Dartmouth College, Hanover, NH, USA.
ORCID: 0000-0003-4116-2455

Nicolai J Birkbak (NJ)

Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.
Department of Molecular Medicine (MOMA), Aarhus University Hospital, Aarhus, Denmark.
Bioinformatics Research Centre (BiRC), Aarhus University, Aarhus, Denmark.
ORCID: 0000-0003-1613-9587

Gareth A Wilson (GA)

Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.

David A Moore (DA)

Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.
Department of Cellular Pathology, University College London Hospitals, London, UK.

Eva Grönroos (E)

Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.
ORCID: 0000-0001-8303-5409

Andrew Rowan (A)

Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.

Sally M Dewhurst (SM)

Laboratory for Cell Biology and Genetics, Rockefeller University, New York, NY, USA.

Jonas Demeulemeester (J)

Cancer Genomics Laboratory, The Francis Crick Institute, London, UK.
Department of Human Genetics, University of Leuven, Leuven, Belgium.
ORCID: 0000-0002-2660-2478

Stefan C Dentro (SC)

Cancer Genomics Laboratory, The Francis Crick Institute, London, UK.
Oxford Big Data Institute, University of Oxford, Oxford, UK.
Experimental Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton, UK.

Stuart Horswell (S)

Department of Bioinformatics and Biostatistics, The Francis Crick Institute, London, UK.
ORCID: 0000-0003-2787-1933

Lewis Au (L)

Renal and Skin Units, The Royal Marsden Hospital NHS Foundation Trust, London, UK.
Cancer Dynamics Laboratory, The Francis Crick Institute, London, UK.

Kerstin Haase (K)

Cancer Genomics Laboratory, The Francis Crick Institute, London, UK.
ORCID: 0000-0002-0944-5618

Mickael Escudero (M)

Department of Bioinformatics and Biostatistics, The Francis Crick Institute, London, UK.
ORCID: 0000-0002-1336-815X

Rachel Rosenthal (R)

Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.
Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.
Bill Lyons Informatics Centre, University College London Cancer Institute, London, UK.

Maise Al Bakir (MA)

Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.

Hang Xu (H)

Stanford Cancer Institute, Stanford, CA, USA.

Kevin Litchfield (K)

Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.

Wei Ting Lu (WT)

Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.
ORCID: 0000-0002-1405-4806

Thanos P Mourikis (TP)

Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.
Cancer Genome Evolution Research Group, University College London Cancer Institute, University College London, London, UK.

Michelle Dietzen (M)

Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.
Cancer Genome Evolution Research Group, University College London Cancer Institute, University College London, London, UK.

Lavinia Spain (L)

Renal and Skin Units, The Royal Marsden Hospital NHS Foundation Trust, London, UK.
Cancer Dynamics Laboratory, The Francis Crick Institute, London, UK.

George D Cresswell (GD)

Bioinformatics and Computational Biology Laboratory, The Francis Crick Institute, London, UK.
ORCID: 0000-0003-3303-068X

Dhruva Biswas (D)

Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.
Bill Lyons Informatics Centre, University College London Cancer Institute, London, UK.
ORCID: 0000-0001-9141-5188

Philippe Lamy (P)

Department of Molecular Medicine (MOMA), Aarhus University Hospital, Aarhus, Denmark.

Iver Nordentoft (I)

Department of Molecular Medicine (MOMA), Aarhus University Hospital, Aarhus, Denmark.

Katja Harbst (K)

Division of Oncology and Pathology, Department of Clinical Sciences Lund, Faculty of Medicine, Lund University, Lund, Sweden.
Lund University Cancer Centre, Lund University, Lund, Sweden.
ORCID: 0000-0002-8225-1510

Francesc Castro-Giner (F)

Department of Biomedicine, Cancer Metastasis Laboratory, University of Basel and University Hospital Basel, Basel, Switzerland.
Swiss Institute of Bioinformatics (SIB), Lausanne, Switzerland.
ORCID: 0000-0001-6111-0754

Lucy R Yates (LR)

Wellcome Trust Sanger Institute, Hinxton, UK.
Department of Clinical Oncology, Guy's and St Thomas' NHS Foundation Trust, London, UK.

Franco Caramia (F)

Division of Research, Peter MacCallum Cancer Centre, University of Melbourne, Melbourne, Victoria, Australia.
ORCID: 0000-0002-5086-2544

Fanny Jaulin (F)

INSERM U1279, Gustave Roussy, Villejuif, France.
ORCID: 0000-0002-5110-1800

Cécile Vicier (C)

Department of Medical Oncology, Institut Paoli-Calmettes, Aix-Marseille University, Marseille, France.

Ian P M Tomlinson (IPM)

Edinburgh Cancer Research Centre, IGMM, University of Edinburgh, Edinburgh, UK.

Priscilla K Brastianos (PK)

Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA.
Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.

Raymond J Cho (RJ)

Department of Dermatology, University of California, San Francisco, San Francisco, CA, USA.
ORCID: 0000-0001-6090-6603

Boris C Bastian (BC)

Department of Dermatology, University of California, San Francisco, San Francisco, CA, USA.
Department of Pathology, University of California, San Francisco, San Francisco, CA, USA.
Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA.
ORCID: 0000-0003-1836-6062

Lars Dyrskjøt (L)

Department of Molecular Medicine (MOMA), Aarhus University Hospital, Aarhus, Denmark.
ORCID: 0000-0001-7061-9851

Göran B Jönsson (GB)

Division of Oncology and Pathology, Department of Clinical Sciences Lund, Faculty of Medicine, Lund University, Lund, Sweden.
Lund University Cancer Centre, Lund University, Lund, Sweden.

Peter Savas (P)

Division of Research, Peter MacCallum Cancer Centre, University of Melbourne, Melbourne, Victoria, Australia.
Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia.
ORCID: 0000-0001-5999-428X

Sherene Loi (S)

Division of Research, Peter MacCallum Cancer Centre, University of Melbourne, Melbourne, Victoria, Australia.
Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia.
ORCID: 0000-0001-6137-9171

Peter J Campbell (PJ)

Wellcome Trust Sanger Institute, Hinxton, UK.
ORCID: 0000-0002-3921-0510

Fabrice Andre (F)

INSERM U981, PRISM Institute, Gustave Roussy, Villejuif, France.
Department of Medical Oncology, Gustave Roussy, Villejuif, France.
Medical School, Université Paris Saclay, Kremlin Bicetre, France.
ORCID: 0000-0001-5795-8357

Nicholas M Luscombe (NM)

Bioinformatics and Computational Biology Laboratory, The Francis Crick Institute, London, UK.
UCL Genetics Institute, Department of Genetics, Evolution & Environment, University College London, London, UK.
Okinawa Institute of Science & Technology, Okinawa, Japan.
ORCID: 0000-0001-5293-4778

Neeltje Steeghs (N)

Department of Medical Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands.

Vivianne C G Tjan-Heijnen (VCG)

Department of Medical Oncology, School of GROW, Maastricht University Medical Center, Maastricht, The Netherlands.

Zoltan Szallasi (Z)

Danish Cancer Society Research Center, Copenhagen, Denmark.
Computational Health Informatics Program, Boston Children's Hospital, Boston, MA, USA.
2nd Department of Pathology, SE-NAP Brain Metastasis Research Group, Semmelweis University, Budapest, Hungary.

Samra Turajlic (S)

Renal and Skin Units, The Royal Marsden Hospital NHS Foundation Trust, London, UK.
Cancer Dynamics Laboratory, The Francis Crick Institute, London, UK.
ORCID: 0000-0001-8846-136X

Mariam Jamal-Hanjani (M)

Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.
Department of Medical Oncology, University College London Hospitals, London, UK.

Peter Van Loo (P)

Cancer Genomics Laboratory, The Francis Crick Institute, London, UK.
ORCID: 0000-0003-0292-1949

Samuel F Bakhoum (SF)

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Roland F Schwarz (RF)

Berlin Institute for Medical Systems Biology, Max Delbrück Center for Molecular Medicine, Berlin, Germany. roland.schwarz@mdc-berlin.de.
German Cancer Consortium (DKTK), partner site Berlin, Berlin, Germany. roland.schwarz@mdc-berlin.de.
German Cancer Research Center (DKFZ), Heidelberg, Germany. roland.schwarz@mdc-berlin.de.
ORCID: 0000-0001-9155-4268

Nicholas McGranahan (N)

Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK. nicholas.mcgranahan.10@ucl.ac.uk.
Cancer Genome Evolution Research Group, University College London Cancer Institute, University College London, London, UK. nicholas.mcgranahan.10@ucl.ac.uk.
ORCID: 0000-0001-9537-4045

Charles Swanton (C)

Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK. charles.swanton@crick.ac.uk.
Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK. charles.swanton@crick.ac.uk.
Department of Medical Oncology, University College London Hospitals, London, UK. charles.swanton@crick.ac.uk.
ORCID: 0000-0002-4299-3018

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Classifications MeSH

questionsmedicales.fr › Phénomènes génétiques › Instabilité du génome › Instabilité des chromosomes › Pervasive chromosomal instability and...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Chromosomes › Chromosomes de mammifère › Chromosomes humains › Chromosomes humains 6-12 et X › Chromosomes humains de la paire 11 › Pervasive chromosomal instability and...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Chromosomes › Chromosomes de mammifère › Chromosomes humains › Chromosomes humains 6-12 et X › Chromosomes humains de la paire 8 › Pervasive chromosomal instability and...
questionsmedicales.fr › Cellules › Cellules cultivées › Clones cellulaires › Pervasive chromosomal instability and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Cyclines › Cycline E › Pervasive chromosomal instability and...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › Variation structurale du génome › Variations de nombre de copies de segment d'ADN › Pervasive chromosomal instability and...
questionsmedicales.fr › Phénomènes biologiques › Évolution biologique › Évolution moléculaire › Pervasive chromosomal instability and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Pervasive chromosomal instability and...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Chromosomes › Caryotype › Pervasive chromosomal instability and...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Déséquilibre allélique › Perte d'hétérozygotie › Pervasive chromosomal instability and...
questionsmedicales.fr › Phénomènes génétiques › Mutagenèse › Pervasive chromosomal instability and...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Processus néoplasiques › Métastase tumorale › Pervasive chromosomal instability and...
questionsmedicales.fr › Tumeurs › Pervasive chromosomal instability and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines oncogènes › Pervasive chromosomal instability and...