Adult liver transplantation: UK clinical guideline - part 2: surgery and post-operation.

guideline liver transplantation

Journal

Frontline gastroenterology
ISSN: 2041-4137
Titre abrégé: Frontline Gastroenterol
Pays: England
ID NLM: 101528589

Informations de publication

Date de publication:
2020
Historique:
received: 27 02 2019
revised: 01 09 2019
accepted: 30 09 2019
entrez: 4 9 2020
pubmed: 4 9 2020
medline: 4 9 2020
Statut: epublish

Résumé

Survival rates for patients following liver transplantation exceed 90% at 12 months and approach 70% at 10 years. Part 1 of this guideline has dealt with all aspects of liver transplantation up to the point of placement on the waiting list. Part 2 explains the organ allocation process, organ donation and organ type and how this influences the choice of recipient. After organ allocation, the transplant surgery and the critical early post-operative period are, of necessity, confined to the liver transplant unit. However, patients will eventually return to their referring secondary care centre with a requirement for ongoing supervision. Part 2 of this guideline concerns three key areas of post liver transplantation care for the non-transplant specialist: (1) overseeing immunosuppression, including interactions and adherence; (2) the transplanted organ and how to initiate investigation of organ dysfunction; and (3) careful oversight of other organ systems, including optimising renal function, cardiovascular health and the psychosocial impact. The crucial significance of this holistic approach becomes more obvious as time passes from the transplant, when patients should expect the responsibility for managing the increasing number of non-liver consequences to lie with primary and secondary care.

Identifiants

pubmed: 32879722
doi: 10.1136/flgastro-2019-101216
pii: flgastro-2019-101216
pmc: PMC7447281
doi:

Types de publication

Journal Article Review

Langues

eng

Pagination

385-396

Informations de copyright

© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

Déclaration de conflit d'intérêts

Competing interests: None declared.

Références

HPB (Oxford). 2010 Apr;12(3):217-24
pubmed: 20590890
Am J Transplant. 2010 Oct;10(10):2305-12
pubmed: 20726963
Liver Transpl Surg. 1999 Jul;5(4):301-9
pubmed: 10388503
Liver Transpl. 2001 Mar;7(3):213-9
pubmed: 11244162
Liver Transpl. 2011 Jan;17(1):15-22
pubmed: 21254340
Ann Transplant. 2013 Dec 18;18:685-96
pubmed: 24346057
J Hepatol. 2009 Nov;51(5):949-59
pubmed: 19775771
Expert Opin Drug Saf. 2016;15(3):303-19
pubmed: 26667069
Liver Transpl. 2017 Mar;23(3):361-374
pubmed: 28006876
Liver Transpl. 2013 Nov;19(11):1252-61
pubmed: 24106037
Liver Transpl. 2006 Oct;12(10):1478-84
pubmed: 16741905
Exp Clin Transplant. 2016 Nov;14(Suppl 3):1-5
pubmed: 27805501
Liver Transpl. 2016 Aug;22(8):1129-35
pubmed: 27081833
Aliment Pharmacol Ther. 2017 Feb;45(4):485-500
pubmed: 27957759
Transplantation. 2001 Sep 27;72(6):1066-72
pubmed: 11579302
Drugs. 2007;67(10):1463-81
pubmed: 17600393
JAMA. 1995 Jan 4;273(1):59-65
pubmed: 7996652
J Ren Care. 2016 Dec;42(4):239-256
pubmed: 27629770
Clin Endocrinol (Oxf). 1996 Apr;44(4):461-6
pubmed: 8706314
Liver Transpl. 2004 Mar;10(3):412-7
pubmed: 15004770
J Hepatol. 2016 Feb;64(2):433-485
pubmed: 26597456
Liver Transpl. 2014 Mar;20(3):281-90
pubmed: 24395145
Best Pract Res Clin Gastroenterol. 2017 Apr;31(2):181-185
pubmed: 28624106
Ann Gastroenterol. 2015 Apr-Jun;28(2):183-192
pubmed: 25830307
Transplant Proc. 2006 Nov;38(9):2971-3
pubmed: 17112877
Transplantation. 1998 Jul 15;66(1):59-66
pubmed: 9679823
J Hepatol. 2000 Oct;33(4):609-15
pubmed: 11059865
Transplantation. 1997 Feb 15;63(3):331-8
pubmed: 9039919
Calcif Tissue Int. 2001 Dec;69(6):321-6
pubmed: 11800228
Liver Transpl. 2015 Jul;21(7):889-96
pubmed: 25880971
Clin Microbiol Infect. 2014 Sep;20 Suppl 7:10-8
pubmed: 24476053
Osteoporos Int. 2001;12(6):484-92
pubmed: 11446565
Transplantation. 2017 Apr;101(4):786-792
pubmed: 27906826
J Hepatol. 2014 Aug;61(2):196-7
pubmed: 24845611
Am J Transplant. 2016 Oct;16(10):2816-2835
pubmed: 27273869
Am J Transplant. 2006 Aug;6(8):1896-905
pubmed: 16889545
Liver Transpl. 2006 Oct;12(10):1473-7
pubmed: 16741902
J Med Econ. 2016 Oct;19(10):995-1002
pubmed: 27172118
Lancet Gastroenterol Hepatol. 2017 Jul;2(7):531-537
pubmed: 28606879
BMJ Open. 2013 Sep 03;3(9):e003287
pubmed: 24002984
Liver Transpl Surg. 1999 May;5(3):204-8
pubmed: 10226111
Liver Transpl. 2012 Jan;18(1):89-99
pubmed: 21837745
Am J Transplant. 2017 Oct;17(10):2668-2678
pubmed: 28321975
Transplantation. 2017 Apr;101(4S Suppl 2):S1-S56
pubmed: 28328734
Liver Transpl. 2008 Feb;14(2):159-72
pubmed: 18236389
Liver Transpl. 2012 Jun;18(6):619-20
pubmed: 22489088
Liver Transpl. 2015 Sep;21(9):1153-9
pubmed: 26013178
J Hepatol. 2008 Oct;49(4):507-19
pubmed: 18715668
Liver Transpl Surg. 1998 Jul;4(4):328-34
pubmed: 9649648
Am J Transplant. 2010 Jun;10(6):1420-7
pubmed: 20486907
World J Hepatol. 2016 Jan 18;8(2):117-22
pubmed: 26807207
Gastroenterology. 2010 Nov;139(5):1619-29, 1629.e1-4
pubmed: 20600035
Pediatr Transplant. 2012 Feb;16(1):41-9
pubmed: 22093689
Clin Transplant. 2012 Sep-Oct;26(5):729-35
pubmed: 22404665
J Autoimmun. 2016 Jan;66:51-9
pubmed: 26350881

Auteurs

Charles Millson (C)

Department of Hepatology, York Teaching Hospitals NHS Foundation Trust, York, UK.

Aisling Considine (A)

Pharmacy department, King's College Hospital NHS Foundation Trust, London, UK.

Matthew E Cramp (ME)

South West Liver Unit, Plymouth Hospitals NHS Trust, Plymouth, UK.

Andrew Holt (A)

Liver Unit, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.

Stefan Hubscher (S)

Department of Cellular Pathology, University of Birmingham, Birmingham, UK.

John Hutchinson (J)

Department of Hepatology, York Teaching Hospitals NHS Foundation Trust, York, UK.

Kate Jones (K)

Liver Transplantation Service, Leeds Teaching Hospitals NHS Trust, Leeds, UK.

Joanna Leithead (J)

Department of Hepatology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.

Steven Masson (S)

Liver Unit, The Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.

Krish Menon (K)

Liver Transplantation & HPB Surgery, King's College Hospital NHS Foundation Trust, London, UK.

Darius Mirza (D)

Liver Transplantation & HPB surgery, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.

James Neuberger (J)

Liver Unit, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.

Raj Prasad (R)

Liver Transplantation & HPB Surgery, Leeds Teaching Hospitals NHS Trust, Leeds, UK.

Anthony Pratt (A)

Pharmacy Department, York Teaching Hospital NHS Foundation Trust, York, UK.

Wendy Prentice (W)

Palliative Care Medicine, King's College Hospital NHS Foundation Trust, London, UK.

Liz Shepherd (L)

Liver Transplantation Service, Royal Free London NHS Foundation Trust, London, UK.

Ken Simpson (K)

Scottish Liver Transplant Unit, Royal Infirmary of Edinburgh, Edinburgh, UK.

Doug Thorburn (D)

Department of Hepatology, Royal Free London NHS Foundation Trust, London, UK.

Rachel Westbrook (R)

Department of Hepatology, Royal Free London NHS Foundation Trust, London, UK.

Dhiraj Tripathi (D)

Liver Unit, University Hospitals Birmingham NHS Foundation Trust, Birminghams, UK.

Classifications MeSH