The antifungal activity of vapour phase of odourless thymol derivate.
Biological activity
Fungi
Gas chromatography
Olfactometry
Trimethylsilyl ether of thymol
Journal
PeerJ
ISSN: 2167-8359
Titre abrégé: PeerJ
Pays: United States
ID NLM: 101603425
Informations de publication
Date de publication:
2020
2020
Historique:
received:
11
02
2020
accepted:
03
07
2020
entrez:
4
9
2020
pubmed:
4
9
2020
medline:
4
9
2020
Statut:
epublish
Résumé
Thymol is a substance with a great therapeutic potential possessing antibacterial and antifungal activity, with a characteristic odour that remains long after application but is not pleasant at higher concentrations. In this study, attention has been focused on describing the chemical and biological properties of the simply prepared trimethylsilyl ether of thymol (kubicin). Interestingly, kubicin has similar volatility as thymol, undergoes hydrolysis in the water (moisture; forming thymol and trimethylsilanol) and can be used at 6,000 times higher concentration than thymol without any negative and irritating odour. Kubicin showed diverse fungistatic and fungicidal activities when tested by direct contact assay, or in vapour phase. The volatile vapour of kubicin was effective on all tested fungal strains. These results suggest that vapours of kubicin might provide an alternative way to fight against fungal contamination.
Identifiants
pubmed: 32879789
doi: 10.7717/peerj.9601
pii: 9601
pmc: PMC7443090
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e9601Informations de copyright
©2020 Kubinec et al.
Déclaration de conflit d'intérêts
The authors declare there are no competing interests.
Références
Antimicrob Agents Chemother. 2005 Jun;49(6):2474-8
pubmed: 15917549
J Chromatogr A. 2007 May 25;1150(1-2):131-5
pubmed: 17339042
IARC Monogr Eval Carcinog Risks Hum. 2008;97:3-471
pubmed: 20232717
Food Chem. 2016 Nov 1;210:402-14
pubmed: 27211664
Front Pharmacol. 2017 Jun 26;8:380
pubmed: 28694777
IARC Monogr Eval Carcinog Risks Hum. 2006;88:1-478
pubmed: 17366697
Int Biodeterior Biodegradation. 2013 Oct;84(100):333-341
pubmed: 24092956
Molecules. 2012 Dec 05;17(12):14418-33
pubmed: 23519243
Lett Appl Microbiol. 2012 May;54(5):433-40
pubmed: 22360347
Sci Rep. 2017 Aug 15;7(1):8211
pubmed: 28811611
Environ Microbiol. 2018 Sep;20(9):3294-3308
pubmed: 30051567
Phytother Res. 2018 Sep;32(9):1688-1706
pubmed: 29785774
J Agric Food Chem. 2018 Aug 15;66(32):8530-8536
pubmed: 30044621
Crit Rev Microbiol. 2005;31(1):1-10
pubmed: 15839400