Clinical utility of combined T2-weighted imaging and T2-mapping in the detection of prostate cancer: a multi-observer study.

BACKGROUND

To evaluate the clinical utility of combined T2-weighted imaging and T2-mapping for the detection of prostate cancer.

METHODS

Forty patients underwent multiparametric magnetic resonance imaging (mpMRI) and T2-mapping of the prostate. Three readers each reviewed two sets of images: T2-weighted fast spin-echo (FSE) sequence (standard T2), and standard T2 in combination with T2-mapping. Each reader assigned probability scores for malignancy to each zone [peripheral zone (PZ) or transition zone (TZ)]. Inter-observer variability for standard T2 and combined standard T2 with T2-mapping were assessed. Diagnostic accuracy was compared between standard T2 and combined standard T2 with T2-mapping.

RESULTS

There was fair agreement between all three readers for standard T2 [intraclass correlation coefficient (ICC) =0.56] and combined standard T2 with T2-mapping (ICC =0.58). There was no significant difference in the area under the receiver operator characteristics curve for standard T2 compared to combined standard T2 with T2-mapping (0.89

CONCLUSIONS

Combination of T2-weighted imaging and T2-mapping could potentially increase Sn for prostate malignancy compared to T2-weighted imaging alone.

Informations de copyright

2020 Quantitative Imaging in Medicine and Surgery. All rights reserved.

Déclaration de conflit d'intérêts

Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at http://dx.doi.org/10.21037/qims-20-222). CHL reports grants and non-financial support from Siemens Healthineers, during the conduct of the study. MT reports grants and non-financial support from Siemens Healthineers, during the conduct of the study; grants and personal fees from CRC 1340/1 (DFG, Germany Research Foundation), outside the submitted work. PA reports grants and non-financial support from Siemens Healthineers, during the conduct of the study; personal fees from b.e.imaging, grants from CRC 1340/1 (DFG, Germany Research Foundation), other from ESR European Society of Radiology, other from DRG Germany Roentgen Society, personal fees and other from CSR Chinese Society of Radiology, outside the submitted work. MH reports grants and non-financial support from Siemens Healthineers, during the conduct of the study; personal fees from b.e.imaging, outside the submitted work. The other author has no conflicts of interest to declare.