Prefrontal resting-state connectivity and antidepressant response: no associations in the ELECT-TDCS trial.
Adult
Antidepressive Agents
/ therapeutic use
Depression
/ drug therapy
Depressive Disorder, Major
/ drug therapy
Double-Blind Method
Escitalopram
/ therapeutic use
Female
Gray Matter
/ diagnostic imaging
Humans
Male
Prefrontal Cortex
/ diagnostic imaging
Rest
Transcranial Direct Current Stimulation
Treatment Outcome
Antidepressant response
Major depressive disorder (MDD)
Non-invasive transcranial brain stimulation (NTBS)
Prefrontal cortex
Resting state functional connectivity (rsFC-MRI)
Transcranial direct current stimulation (tDCS)
Journal
European archives of psychiatry and clinical neuroscience
ISSN: 1433-8491
Titre abrégé: Eur Arch Psychiatry Clin Neurosci
Pays: Germany
ID NLM: 9103030
Informations de publication
Date de publication:
Feb 2021
Feb 2021
Historique:
received:
30
04
2020
accepted:
20
08
2020
pubmed:
4
9
2020
medline:
14
1
2022
entrez:
4
9
2020
Statut:
ppublish
Résumé
Functional and structural MRI of prefrontal cortex (PFC) may provide putative biomarkers for predicting the treatment response to transcranial direct current stimulation (tDCS) in depression. A recent MRI study from ELECT-TDCS (Escitalopram versus Electrical Direct-Current Theror Depression Study) showed that depression improvement after tDCS was associated with gray matter volumes of PFC subregions. Based thereon, we investigated whether antidepressant effects of tDCS are similarly associated with baseline resting-state functional connectivity (rsFC). A subgroup of 51 patients underwent baseline rsFC-MRI. All patients of ELECT-TDCS were randomized to three treatment arms for 10 weeks (anodal-left, cathodal-right PFC tDCS plus placebo medication; escitalopram 10 mg/day for 3 weeks and 20 mg/day thereafter plus sham tDCS; and placebo medication plus sham tDCS). RsFC was calculated for various PFC regions and analyzed in relation to the individual antidepressant response. There was no significant association between baseline PFC connectivity of essential structural regions, nor any other PFC regions (after correction for multiple comparisons) and patients' individual antidepressant response. This study did not reveal an association between antidepressants effects of tDCS and baseline rsFC, unlike the gray matter volume findings. Thus, the antidepressant effects of tDCS may be differentially related to structural and functional MRI measurements.
Identifiants
pubmed: 32880057
doi: 10.1007/s00406-020-01187-y
pii: 10.1007/s00406-020-01187-y
doi:
Substances chimiques
Antidepressive Agents
0
Escitalopram
4O4S742ANY
Types de publication
Comparative Study
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
123-134Subventions
Organisme : FAPESP
ID : 2012/20911-5
Organisme : BMBF
ID : 01EE1403E
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