Structural and functional characterization of C0021158, a high-affinity monoclonal antibody that inhibits Arginase 2 function via a novel non-competitive mechanism of action.
ARG2
ARG2 epitope
ARG2 neutralization
Arginase 2
antibody co-crystal structure
cancer therapeutics
human monoclonal antibody
phage display selections
Journal
mAbs
ISSN: 1942-0870
Titre abrégé: MAbs
Pays: United States
ID NLM: 101479829
Informations de publication
Date de publication:
Historique:
entrez:
4
9
2020
pubmed:
4
9
2020
medline:
6
7
2021
Statut:
ppublish
Résumé
Arginase 2 (ARG2) is a binuclear manganese metalloenzyme that catalyzes the hydrolysis of L-arginine. The dysregulated expression of ARG2 within specific tumor microenvironments generates an immunosuppressive niche that effectively renders the tumor 'invisible' to the host's immune system. Increased ARG2 expression leads to a concomitant depletion of local L-arginine levels, which in turn leads to suppression of anti-tumor T-cell-mediated immune responses. Here we describe the isolation and characterization of a high affinity antibody (C0021158) that inhibits ARG2 enzymatic function completely, effectively restoring T-cell proliferation
Identifiants
pubmed: 32880207
doi: 10.1080/19420862.2020.1801230
pmc: PMC7531564
doi:
Substances chimiques
Single-Chain Antibodies
0
ARG2 protein, human
EC 3.5.3.1
Arginase
EC 3.5.3.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Video-Audio Media
Langues
eng
Sous-ensembles de citation
IM
Pagination
1801230Subventions
Organisme : Cancer Research UK
ID : C1362/A20263
Pays : United Kingdom
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