Serum Concentrations of Trace Elements/Minerals in Patients with Diffuse Systemic Sclerosis.
Copper
Diffuse systemic sclerosis
Pulmonary fibrosis
Systemic sclerosis
Trace elements and minerals
Journal
Biological trace element research
ISSN: 1559-0720
Titre abrégé: Biol Trace Elem Res
Pays: United States
ID NLM: 7911509
Informations de publication
Date de publication:
Jul 2021
Jul 2021
Historique:
received:
01
06
2020
accepted:
01
09
2020
pubmed:
4
9
2020
medline:
23
6
2021
entrez:
4
9
2020
Statut:
ppublish
Résumé
Trace elements and minerals are essential for cellular physiology and components of biological structures. Previous studies demonstrated that proper serum concentration of trace elements/minerals such as copper maintains optimum function of the immune system, and trace elements/mineral imbalance was associated with various autoimmune disorders. The current study aimed to measure the serum concentrations of trace elements/minerals potassium (K), sodium (Na), chlorine (Cl), calcium (Ca), phosphorus (P), iron (Fe), copper (Cu), and magnesium (Mg) in patients with diffuse systemic sclerosis (dSSc). Fifty-one patients with dSSc were enrolled in this study. Healthy 106 participants with similar age and gender to the patients were used as healthy control. Roche Cobas 8000 was used to measure the serum concentrations of K, Na, Cl, Ca, P, Fe, Cu, and Mg. The results demonstrated that the serum concentrations of K, Ca, P, and Mg were significantly increased in patients with dSSc, while the serum concentration of Cu was decreased. We next examined the serum concentration of trace elements/minerals in dSSc patients with or without pulmonary fibrosis. The result revealed that the serum concentration of Cu in dSSc patients with pulmonary fibrosis was significantly lower than that in patents without pulmonary fibrosis. Our study provided evidence that serum concentrations of K, Ca, P, Cu, and Mg were changed significantly in dSSc patients, and lower serum concentration of Cu was associated with pulmonary fibrosis.
Identifiants
pubmed: 32880801
doi: 10.1007/s12011-020-02368-5
pii: 10.1007/s12011-020-02368-5
doi:
Substances chimiques
Minerals
0
Trace Elements
0
Copper
789U1901C5
Sodium
9NEZ333N27
Magnesium
I38ZP9992A
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2440-2443Subventions
Organisme : Natural Science Foundation of Guangxi Province
ID : 2018JJA140045
Organisme : Guangxi Science and Technology Base and Special Fund for Talents
ID : 2018AD19267
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