Prognostic value of preoperative lymphocyte-to-monocyte ratio in oral cancer patients and establishment of a dynamic nomogram.
dynamic nomogram
inverse probability of treatment weighting analysis
lymphocyte-to-monocyte ratio
oral cancer
overall survival
propensity score-matched analysis
Journal
Oral diseases
ISSN: 1601-0825
Titre abrégé: Oral Dis
Pays: Denmark
ID NLM: 9508565
Informations de publication
Date de publication:
Jul 2021
Jul 2021
Historique:
revised:
31
07
2020
received:
24
05
2020
accepted:
24
08
2020
pubmed:
4
9
2020
medline:
16
6
2021
entrez:
4
9
2020
Statut:
ppublish
Résumé
To assess the association of preoperative lymphocyte-to-monocyte ratio (LMR) and overall survival (OS) in patients with oral cancer and develop a dynamic nomogram for individualized survival prediction. The prognostic value of LMR was evaluated in a large-scale cohort with 651 postoperative patients with oral cancer between January 2010 and December 2017. Propensity score-matched (PSM) analysis and inverse probability of treatment weighting (IPTW) analysis were performed to further verify the prognostic value of LMR. A dynamic nomogram was then developed based on the LMR and clinicopathological features, and its predictive performance and clinical utility were evaluated. A high LMR was significantly associated with better OS of patients with oral cancer (HR = 0.65; 95% CI = 0.44-0.98). The similar association was also observed in the PSM and IPTW analyses. Moreover, compared with TNM staging system, the dynamic nomogram based on the LMR exhibited more excellent predictive performance (0.72 versus 0.64, p < .001), with calibration curves (1,000 bootstrap resamples) suggesting good match between the actual and predicted probabilities. Decision curve analyses (DCAs) showed a more significant positive net benefit in the practical ranges of threshold probabilities using the dynamic nomogram. Preoperative LMR may serve as an easily accessible and non-invasive prognostic biomarker for predicting the prognosis of patients with oral cancer. A dynamic nomogram based on the LMR may show more convenience in survival prediction for patients with oral cancer. Further future studies are warranted to confirm our findings.
Types de publication
Journal Article
Langues
eng
Pagination
1127-1136Subventions
Organisme : Scientific Research Talents Training Project of Health and Family Planning Health Commission in Fujian Province
ID : 2019-ZQN-68
Organisme : Scientific Research Talents Training Project of Health and Family Planning Health Commission in Fujian Province
ID : 2018-1-71
Organisme : Scientific Research Talents Training Project of Health and Family Planning Health Commission in Fujian Province
ID : 2017-ZQN-57
Organisme : Fujian Natural Science Foundation Program
ID : 2019J01314
Organisme : High-level Talents Research Start-up Project of Fujian Medical University
ID : XRCZX2018001
Organisme : Program for New Century Excellent Talents in Fujian Province
ID : 2018B029
Organisme : Startup Fund for Scientific Research of Fujian Medical University
ID : 2017XQ1011
Organisme : Joint Funds For The Innovation Of Science And Technology Of Fujian Province
ID : 2017Y9103
Informations de copyright
© 2020 Wiley Periodicals LLC.
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