IL-12p40 gene expression in lung and hilar lymph nodes of MPS-resistant pigs.
Mycoplasma hyopneumoniae
cytokine
disease resistance
histopathology
landrace pigs
Journal
Animal science journal = Nihon chikusan Gakkaiho
ISSN: 1740-0929
Titre abrégé: Anim Sci J
Pays: Australia
ID NLM: 100956805
Informations de publication
Date de publication:
Historique:
received:
08
05
2020
revised:
06
07
2020
accepted:
02
08
2020
entrez:
4
9
2020
pubmed:
4
9
2020
medline:
11
11
2020
Statut:
ppublish
Résumé
Mycoplasma pneumonia of swine (MPS) is caused by Mycoplasma hyopneumoniae (M.hp) and is a common chronic respiratory disease of pigs. Recently, a genetically selected variant of the Landrace pig (Miyagino L2) has a lower incidence of pulmonary MPS lesions. We investigated the pathological and immunological characteristics of MPS resistance in these pigs (n = 24) by comparing with the normal landrace pig (control: n = 24). The pathological MPS lung lesion score in MPS-selected landrace pigs was significantly lower than in the control. The gene expression of interleukin (IL)-12p40, which acts as a chemoattractant and a component of the bioactive cytokines IL-12 and IL-23, was significantly higher at the hilar lymph nodes, lung, and spleen in MPS-selected landrace pigs than in control landrace pigs, and these were negatively correlated with the macroscopic MPS lung lesion score. In summary, we demonstrate that resistance against MPS in Miyagino L2 pigs is associated with IL-12p40 up-regulation, in comparison with normal landrace pigs without the MPS vaccine. In addition, a comparative study of macroscopic MPS lung lesions and IL-12p40 gene expression in lung and hilar lymph nodes may lead to beneficial selection traits for the genetic selection for MPS resistance in pigs.
Substances chimiques
Interleukin-12 Subunit p40
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13450Subventions
Organisme : Program for Promotion of Basic Applied Research for Innovations in Bio-oriented Industry
Organisme : Ito foundation
Organisme : Japan Racing Association
ID : 272
Organisme : Bio-oriented Technology Research Advancement Institution
ID : 01002A
Commentaires et corrections
Type : ErratumIn
Informations de copyright
© 2020 Japanese Society of Animal Science.
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