Effects of bilingualism on age at onset in two clinical Alzheimer's disease variants.
Alzheimer's disease
bilingualism
cognitive reserve
dementia
multilingualism
primary progressive aphasia
Journal
Alzheimer's & dementia : the journal of the Alzheimer's Association
ISSN: 1552-5279
Titre abrégé: Alzheimers Dement
Pays: United States
ID NLM: 101231978
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
08
08
2019
revised:
26
03
2020
accepted:
10
07
2020
pubmed:
4
9
2020
medline:
12
11
2021
entrez:
4
9
2020
Statut:
ppublish
Résumé
The effect of bilingualism on age at onset has yet to be examined within different clinical variants of Alzheimer's disease. We reviewed the research charts of 287 well-characterized participants with either amnestic Alzheimer's dementia or logopenic variant primary progressive aphasia (lvPPA) and identified bilingual speakers based on regular use of two or more languages and/or ability to communicate with native speakers in two or more languages. We evaluated whether bilingual speakers demonstrated a delay in age of symptom onset relative to monolingual speakers while controlling for other variables known to influence cognitive reserve. A 5-year delay in age at symptom onset was observed for bilingual relative to monolingual speakers with lvPPA. This delay in onset was not observed in the amnestic Alzheimer's dementia cohort. Bilingualism may serve as a unique cognitive reserve variable in lvPPA, but not in amnestic Alzheimer's dementia.
Identifiants
pubmed: 32881346
doi: 10.1002/alz.12170
pmc: PMC7902304
mid: NIHMS1641004
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1704-1713Subventions
Organisme : NIA NIH HHS
ID : P50 AG023501
Pays : United States
Organisme : NIH HHS
ID : NIA P01 AG019724
Pays : United States
Organisme : NIDCD NIH HHS
ID : F31 DC016229
Pays : United States
Organisme : NIH HHS
ID : NIDCD K24 DC015544
Pays : United States
Organisme : NIH HHS
ID : NIDCD R01 DC016291
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS050915
Pays : United States
Organisme : NIH HHS
ID : NIDCD K23 DC018021
Pays : United States
Organisme : NIDCD NIH HHS
ID : K24 DC015544
Pays : United States
Organisme : NIH HHS
ID : NIDCD F31DC016229
Pays : United States
Organisme : NIDCD NIH HHS
ID : K23 DC018021
Pays : United States
Organisme : NIH HHS
ID : NIA P50 AG023501
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG062422
Pays : United States
Organisme : NIA NIH HHS
ID : P01 AG019724
Pays : United States
Organisme : NIDCD NIH HHS
ID : R01 DC016291
Pays : United States
Informations de copyright
© 2020 the Alzheimer's Association.
Références
Neuropsychologia. 2007 Jan 28;45(2):459-64
pubmed: 17125807
Neuropsychologia. 2011 Dec;49(14):3826-30
pubmed: 22001315
Alzheimer Dis Assoc Disord. 2010 Apr-Jun;24(2):118-25
pubmed: 20505429
Neurology. 2011 Mar 15;76(11):1006-14
pubmed: 21325651
Cogn Behav Neurol. 2003 Dec;16(4):211-8
pubmed: 14665820
J Int Neuropsychol Soc. 2002 Mar;8(3):448-60
pubmed: 11939702
Neurology. 2001 Dec 26;57(12):2236-42
pubmed: 11756603
Daedalus. 2013 Summer;142(3):141-154
pubmed: 25018562
Arch Neurol. 2007 Mar;64(3):416-20
pubmed: 17353386
Neurology. 2013 Nov 26;81(22):1938-44
pubmed: 24198291
Lancet Neurol. 2012 Nov;11(11):1006-12
pubmed: 23079557
J Alzheimers Dis. 2012;29(1):99-108
pubmed: 22232011
Neuropsychologia. 2017 May;99:207-212
pubmed: 28322905
Int J Billing. 2011 Dec;15(4):408-425
pubmed: 22518091
J Neurosci. 2011 Jun 15;31(24):8780-5
pubmed: 21677162
Brain. 2013 Nov;136(Pt 11):3461-73
pubmed: 24056533
Mem Cognit. 2005 Oct;33(7):1220-34
pubmed: 16532855
Brain. 2011 Oct;134(Pt 10):3011-29
pubmed: 21666264
Proc Natl Acad Sci U S A. 2013 Jul 9;110(28):11606-11
pubmed: 23798398
Biomed Res Int. 2016;2016:7069274
pubmed: 26881224
Ann Neurol. 2017 Mar;81(3):430-443
pubmed: 28133816
Cognition. 2013 Nov;129(2):256-63
pubmed: 23948209
Neurology. 2009 Aug 4;73(5):356-61
pubmed: 19652139
Acta Psychiatr Scand. 2009 Apr;119(4):252-65
pubmed: 19236314
Epidemiology. 2009 Sep;20(5):766-74
pubmed: 19593152
Front Aging Neurosci. 2016 Jan 12;7:249
pubmed: 26793100
J Alzheimers Dis. 2017;58(1):45-54
pubmed: 28387680
Hum Brain Mapp. 2015 Nov;36(11):4421-37
pubmed: 26260856
Mem Cognit. 2012 Nov;40(8):1314-30
pubmed: 22907206
Neurology. 2010 Nov 9;75(19):1726-9
pubmed: 21060095
Cognition. 2010 Jan;114(1):29-41
pubmed: 19793584
Cortex. 2015 Dec;73:356-7
pubmed: 26277042
Neuroimage. 2014 Jan 1;84:495-504
pubmed: 24018306
J Gerontol B Psychol Sci Soc Sci. 2013 Jan;68(1):8-12
pubmed: 22454387
Ann Neurol. 2004 Mar;55(3):335-46
pubmed: 14991811
Ann Neurol. 2008 Jun;63(6):709-19
pubmed: 18412267
Acta Neuropathol. 2007 Jul;114(1):31-8
pubmed: 17569065
Alzheimers Dement. 2011 May;7(3):263-9
pubmed: 21514250
Cognition. 2015 Apr;137:40-46
pubmed: 25596355
Alzheimer Dis Assoc Disord. 2020 Jul-Sep;34(3):225-230
pubmed: 32049674
Neuropsychology. 2014 Mar;28(2):238-46
pubmed: 24188113
J Exp Child Psychol. 2012 Mar;111(3):455-67
pubmed: 22169351
JAMA Neurol. 2018 Mar 1;75(3):342-352
pubmed: 29309493
Neurology. 2002 Nov 26;59(10):1594-9
pubmed: 12451203
Neuropsychology. 2015 Jan;29(1):139-50
pubmed: 24933492
J Int Neuropsychol Soc. 2011 Jul;17(4):593-601
pubmed: 21411036