Assessing dehydration status in dengue patients using urine colourimetry and mobile phone technology.
Journal
PLoS neglected tropical diseases
ISSN: 1935-2735
Titre abrégé: PLoS Negl Trop Dis
Pays: United States
ID NLM: 101291488
Informations de publication
Date de publication:
09 2020
09 2020
Historique:
received:
12
02
2020
accepted:
04
07
2020
entrez:
4
9
2020
pubmed:
4
9
2020
medline:
28
10
2020
Statut:
epublish
Résumé
Dengue is a systemic and dynamic disease with symptoms ranging from undifferentiated fever to dengue shock syndrome. Assessment of patients' severity of dehydration is integral to appropriate care and management. Urine colour has been shown to have a high correlation with overall assessment of hydration status. This study tests the feasibility of measuring dehydration severity in dengue fever patients by comparing urine colour captured by mobile phone cameras to established laboratory parameters. Photos of urine samples were taken in a customized photo booth, then processed using Adobe Photoshop to index urine colour into the red, green, and blue (RGB) colour space and assigned a unique RGB value. The RGB values were then correlated with patients' clinical and laboratory hydration indices using Pearson's correlation and multiple linear regression. There were strong correlations between urine osmolality and the RGB of urine colour, with r = -0.701 (red), r = -0.741 (green), and r = -0.761 (blue) (all p-value <0.05). There were strong correlations between urine specific gravity and the RGB of urine colour, with r = -0.759 (red), r = -0.785 (green), and r = -0.820 (blue) (all p-value <0.05). The blue component had the highest correlations with urine specific gravity and urine osmolality. There were moderate correlations between RGB components and serum urea, at r = -0.338 (red), -0.329 (green), -0.360 (blue). In terms of urine biochemical parameters linked to dehydration, multiple linear regression studies showed that the green colourimetry code was predictive of urine osmolality (β coefficient -0.082, p-value <0.001) while the blue colourimetry code was predictive of urine specific gravity (β coefficient -2,946.255, p-value 0.007). Urine colourimetry using mobile phones was highly correlated with the hydration status of dengue patients, making it a potentially useful hydration status tool.
Sections du résumé
BACKGROUND
Dengue is a systemic and dynamic disease with symptoms ranging from undifferentiated fever to dengue shock syndrome. Assessment of patients' severity of dehydration is integral to appropriate care and management. Urine colour has been shown to have a high correlation with overall assessment of hydration status. This study tests the feasibility of measuring dehydration severity in dengue fever patients by comparing urine colour captured by mobile phone cameras to established laboratory parameters.
METHODOLOGY/PRINCIPAL FINDINGS
Photos of urine samples were taken in a customized photo booth, then processed using Adobe Photoshop to index urine colour into the red, green, and blue (RGB) colour space and assigned a unique RGB value. The RGB values were then correlated with patients' clinical and laboratory hydration indices using Pearson's correlation and multiple linear regression. There were strong correlations between urine osmolality and the RGB of urine colour, with r = -0.701 (red), r = -0.741 (green), and r = -0.761 (blue) (all p-value <0.05). There were strong correlations between urine specific gravity and the RGB of urine colour, with r = -0.759 (red), r = -0.785 (green), and r = -0.820 (blue) (all p-value <0.05). The blue component had the highest correlations with urine specific gravity and urine osmolality. There were moderate correlations between RGB components and serum urea, at r = -0.338 (red), -0.329 (green), -0.360 (blue). In terms of urine biochemical parameters linked to dehydration, multiple linear regression studies showed that the green colourimetry code was predictive of urine osmolality (β coefficient -0.082, p-value <0.001) while the blue colourimetry code was predictive of urine specific gravity (β coefficient -2,946.255, p-value 0.007).
CONCLUSIONS/SIGNIFICANCE
Urine colourimetry using mobile phones was highly correlated with the hydration status of dengue patients, making it a potentially useful hydration status tool.
Identifiants
pubmed: 32881914
doi: 10.1371/journal.pntd.0008562
pii: PNTD-D-20-00228
pmc: PMC7470395
doi:
Types de publication
Evaluation Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0008562Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Southeast Asian J Trop Med Public Health. 2010 Jan;41(1):72-6
pubmed: 20578484
J Infect Dis. 1997 Aug;176(2):313-21
pubmed: 9237695
Anaesthesia. 1999 Feb;54(2):189-92
pubmed: 10215718
J Sports Sci. 2006 Aug;24(8):869-73
pubmed: 16815782
PLoS One. 2017 Oct 4;12(10):e0183544
pubmed: 28977019
Int J Sport Nutr. 1994 Sep;4(3):265-79
pubmed: 7987361
Emerg Infect Dis. 2003 Aug;9(8):1003-6
pubmed: 12967502
Appl Opt. 2013 Jul 20;52(21):5262-71
pubmed: 23872775
Biol Res Nurs. 2006 Jan;7(3):197-203
pubmed: 16552947
West J Nurs Res. 2002 Mar;24(2):132-42
pubmed: 11858345
Lab Chip. 2012 Nov 7;12(21):4240-3
pubmed: 22996728
Eur J Nutr. 2020 Aug;59(5):2171-2181
pubmed: 31428854
Br J Nutr. 2013 Jan 28;109(2):313-21
pubmed: 22716932
Int J Sport Nutr. 1998 Dec;8(4):345-55
pubmed: 9841955
Ann Acad Med Singap. 2006 Nov;35(11):783-9
pubmed: 17160194
Med Sci Sports. 1974 Summer;6(2):129-32
pubmed: 4461972
Arch Gerontol Geriatr. 2008 Nov-Dec;47(3):340-55
pubmed: 17996966
Curr Opin Clin Nutr Metab Care. 2002 Sep;5(5):519-24
pubmed: 12172475
Eur J Clin Nutr. 2013 Sep;67(9):939-43
pubmed: 23695204
Forensic Sci Int. 2014 Feb;235:8-13
pubmed: 24447445
Am J Clin Nutr. 2010 Sep;92(3):565-73
pubmed: 20631205
Appl Physiol Nutr Metab. 2006 Jun;31(3):320-7
pubmed: 16770361
Clin Chem. 1977 Dec;23(12):2238-41
pubmed: 923073
Int J Sport Nutr Exerc Metab. 2005 Jun;15(3):236-51
pubmed: 16131695