Association of mid-life serum lipid levels with late-life brain volumes: The atherosclerosis risk in communities neurocognitive study (ARICNCS).
Brain volume
Lipid levels
Triglyceride
Journal
NeuroImage
ISSN: 1095-9572
Titre abrégé: Neuroimage
Pays: United States
ID NLM: 9215515
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
10
06
2020
revised:
20
08
2020
accepted:
26
08
2020
pubmed:
4
9
2020
medline:
9
3
2021
entrez:
4
9
2020
Statut:
ppublish
Résumé
Limited information exists regarding the association between midlife lipid levels and late-life total and regional brain volumes. We studied 1872 participants in the longitudinal community-based Atherosclerosis Risk in Communities Neurocognitive Study. Serum lipid levels were measured in 1987-1989 (mean age, 53 ± 5 years). Participants underwent 3T brain MRI scans in 2011-2013. Brain volumes were measured using FreeSurfer image analysis software. Linear regression models were used to assess the associations between serum lipids and brain volumes modeled in standard deviation (SD) units, adjusting for potential confounders. In adjusted analyses, one SD higher low-density lipoprotein cholesterol (LDL) levels were associated with larger total brain volumes (β 0.033, 95% CI 0.006-0.060) as well as larger volumes of the temporal (β 0.038, 95% CI 0.003-0.074) and parietal lobes (β 0.044, 95% CI 0.009-0.07) and Alzheimer disease-related region (β 0.048, 95% CI 0.048-0.085). Higher triglyceride levels were associated with smaller total brain volumes (β -0.033, 95% CI -0.060, -0.007). The associations between LDL levels and brain volumes were modified by age (P for interaction <0.001), with higher LDL levels associated with larger total and regional brain volumes only among adults >53 years at baseline, and were attenuated after application of weights to account for informative attrition, although associations with the parietal and Alzheimer's disease-related region remained significant. High-density lipoprotein cholesterol was not associated with brain volumes. Higher LDL levels in late midlife were associated with larger brain volumes later in life, while higher triglyceride levels were associated with smaller brain volumes. These associations were driven by adults >53 years at baseline.
Sections du résumé
BACKGROUND
Limited information exists regarding the association between midlife lipid levels and late-life total and regional brain volumes.
METHODS
We studied 1872 participants in the longitudinal community-based Atherosclerosis Risk in Communities Neurocognitive Study. Serum lipid levels were measured in 1987-1989 (mean age, 53 ± 5 years). Participants underwent 3T brain MRI scans in 2011-2013. Brain volumes were measured using FreeSurfer image analysis software. Linear regression models were used to assess the associations between serum lipids and brain volumes modeled in standard deviation (SD) units, adjusting for potential confounders.
RESULTS
In adjusted analyses, one SD higher low-density lipoprotein cholesterol (LDL) levels were associated with larger total brain volumes (β 0.033, 95% CI 0.006-0.060) as well as larger volumes of the temporal (β 0.038, 95% CI 0.003-0.074) and parietal lobes (β 0.044, 95% CI 0.009-0.07) and Alzheimer disease-related region (β 0.048, 95% CI 0.048-0.085). Higher triglyceride levels were associated with smaller total brain volumes (β -0.033, 95% CI -0.060, -0.007). The associations between LDL levels and brain volumes were modified by age (P for interaction <0.001), with higher LDL levels associated with larger total and regional brain volumes only among adults >53 years at baseline, and were attenuated after application of weights to account for informative attrition, although associations with the parietal and Alzheimer's disease-related region remained significant. High-density lipoprotein cholesterol was not associated with brain volumes.
CONCLUSION
Higher LDL levels in late midlife were associated with larger brain volumes later in life, while higher triglyceride levels were associated with smaller brain volumes. These associations were driven by adults >53 years at baseline.
Identifiants
pubmed: 32882383
pii: S1053-8119(20)30810-7
doi: 10.1016/j.neuroimage.2020.117324
pmc: PMC9006082
mid: NIHMS1792000
pii:
doi:
Substances chimiques
Lipids
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
117324Subventions
Organisme : NHLBI NIH HHS
ID : U01 HL096812
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL096902
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700002C
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700001I
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL096814
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL070825
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700003I
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG066511
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL096917
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL130025
Pays : United States
Organisme : American Heart Association-American Stroke Association
ID : 16EIA26410001
Pays : United States
Organisme : NHLBI NIH HHS
ID : K24 HL148521
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700004I
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700005C
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700001C
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700003C
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL096899
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700004C
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700002I
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700005I
Pays : United States
Informations de copyright
Copyright © 2020. Published by Elsevier Inc.
Références
Neuron. 2007 Oct 4;56(1):66-78
pubmed: 17920016
J Cell Sci. 2010 Feb 15;123(Pt 4):595-605
pubmed: 20103534
Arterioscler Thromb Vasc Biol. 2000 Oct;20(10):2255-60
pubmed: 11031212
Neurology. 2005 May 24;64(10):1689-95
pubmed: 15911792
Arch Neurol. 1989 Feb;46(2):141-5
pubmed: 2916953
Neuron. 2002 Jan 31;33(3):341-55
pubmed: 11832223
Ann Intern Med. 1997 May 15;126(10):753-60
pubmed: 9148647
Diabetes Care. 2014 Sep;37(9):2515-21
pubmed: 24947788
Neurology. 2000 Jan 11;54(1):240-2
pubmed: 10636159
J Neurosci. 2010 Dec 15;30(50):17068-78
pubmed: 21159977
Am J Epidemiol. 1989 Apr;129(4):687-702
pubmed: 2646917
Dement Geriatr Cogn Disord. 2009;28(1):75-80
pubmed: 19648749
Neurology. 2011 Feb 8;76(6):518-25
pubmed: 21288982
Stroke. 2015 Feb;46(2):433-40
pubmed: 25563642
Am J Physiol Cell Physiol. 2017 Apr 1;312(4):C500-C516
pubmed: 28077357
Radiology. 2016 Jan;278(1):198-204
pubmed: 26218598
Neurology. 1997 May;48(5):1297-304
pubmed: 9153461
Neurology. 2005 Jan 25;64(2):277-81
pubmed: 15668425
Alzheimers Dement. 2018 Feb;14(2):167-177
pubmed: 28916238
J Biol Chem. 1997 Dec 5;272(49):30766-73
pubmed: 9388216
Neurology. 2010 Nov 23;75(21):1888-95
pubmed: 21068429
Neurobiol Dis. 2000 Aug;7(4):321-31
pubmed: 10964604
Lancet. 2001 Jul 21;358(9277):201-5
pubmed: 11476837
Alzheimers Dement. 2015 Sep;11(9):1098-109
pubmed: 26397878
Arch Neurol. 2009 Dec;66(12):1469-75
pubmed: 20008650
J Neurol Neurosurg Psychiatry. 2009 Nov;80(11):1194-201
pubmed: 19692426
Am J Epidemiol. 2018 Apr 1;187(4):767-776
pubmed: 29617947
Epidemiology. 2012 Jan;23(1):119-28
pubmed: 21989136
Neurology. 2011 Apr 19;76(16):1395-402
pubmed: 21490323
Neurosci Lett. 2009 Oct 2;462(1):89-93
pubmed: 19560513
Clin Chem. 1972 Jun;18(6):499-502
pubmed: 4337382
Neurology. 2001 Jan 9;56(1):42-8
pubmed: 11148234
Epidemiology. 2013 Nov;24(6):886-93
pubmed: 24030502
Arterioscler Thromb Vasc Biol. 2004 May;24(5):806-15
pubmed: 14764421
JAMA Neurol. 2017 Oct 1;74(10):1246-1254
pubmed: 28783817
Metab Brain Dis. 2014 Sep;29(3):593-608
pubmed: 24782046
J Neurol Neurosurg Psychiatry. 2002 Jun;72(6):732-6
pubmed: 12023414
Eur J Neurol. 2016 Mar;23(3):656-63
pubmed: 26725994
Alzheimers Dement (Amst). 2016;2:1-11
pubmed: 26949733
Arch Intern Med. 2003 May 12;163(9):1053-7
pubmed: 12742802
Brain. 1996 Dec;119 ( Pt 6):2001-7
pubmed: 9010004
JAMA. 2001 May 16;285(19):2486-97
pubmed: 11368702
Ann Intern Med. 2002 Aug 6;137(3):149-55
pubmed: 12160362
Neuroimage. 2011 Feb 14;54(4):2659-71
pubmed: 21035552
Neuroimage. 2005 Apr 15;25(3):783-92
pubmed: 15808979
Neuroradiology. 2019 Jun;61(6):703-710
pubmed: 31011773
Cereb Cortex. 2009 Mar;19(3):497-510
pubmed: 18632739
Epidemiology. 2000 Sep;11(5):561-70
pubmed: 10955409