Implication of Potassium Channels in the Pathophysiology of Pulmonary Arterial Hypertension.
Animals
Drug Delivery Systems
Humans
Kv1.5 Potassium Channel
/ metabolism
Nerve Tissue Proteins
/ metabolism
Potassium Channels
/ genetics
Potassium Channels, Inwardly Rectifying
/ metabolism
Potassium Channels, Tandem Pore Domain
/ metabolism
Pulmonary Arterial Hypertension
/ drug therapy
Sulfonylurea Receptors
/ metabolism
ABCC8
ABCC9
K2P3.1
KCNA5
KCNK3
Kv1.5
SUR1
SUR2
Journal
Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414
Informations de publication
Date de publication:
01 09 2020
01 09 2020
Historique:
received:
30
06
2020
revised:
24
08
2020
accepted:
27
08
2020
entrez:
5
9
2020
pubmed:
5
9
2020
medline:
8
9
2021
Statut:
epublish
Résumé
Pulmonary arterial hypertension (PAH) is a rare and severe cardiopulmonary disease without curative treatments. PAH is a multifactorial disease that involves genetic predisposition, epigenetic factors, and environmental factors (drugs, toxins, viruses, hypoxia, and inflammation), which contribute to the initiation or development of irreversible remodeling of the pulmonary vessels. The recent identification of loss-of-function mutations in
Identifiants
pubmed: 32882918
pii: biom10091261
doi: 10.3390/biom10091261
pmc: PMC7564204
pii:
doi:
Substances chimiques
ABCC8 protein, human
0
ABCC9 protein, human
0
KCNA5 protein, human
0
Kir6.2 channel
0
Kv1.5 Potassium Channel
0
Nerve Tissue Proteins
0
Potassium Channels
0
Potassium Channels, Inwardly Rectifying
0
Potassium Channels, Tandem Pore Domain
0
Sulfonylurea Receptors
0
potassium channel subfamily K member 3
1HQ3YCN4GS
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Funding Agency for Research
ID : ANR-18-CE14-0023
Pays : International
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