Coxsackievirus-B4 Infection Can Induce the Expression of Human Endogenous Retrovirus W in Primary Cells.
PBMCs
endogenous retrovirus
enterovirus
macrophages
pancreatic cells
Journal
Microorganisms
ISSN: 2076-2607
Titre abrégé: Microorganisms
Pays: Switzerland
ID NLM: 101625893
Informations de publication
Date de publication:
01 Sep 2020
01 Sep 2020
Historique:
received:
30
07
2020
revised:
27
08
2020
accepted:
28
08
2020
entrez:
5
9
2020
pubmed:
5
9
2020
medline:
5
9
2020
Statut:
epublish
Résumé
Human Endogenous Retrovirus W Envelope (HERV-W ENV) mRNA or protein can be found in peripheral blood mononuclear cells (PBMCs) and exocrine pancreas of patients with type 1 diabetes (T1D). Further, previous observations have shown an association between enteroviral infection and development of T1D; specifically, coxsackievirus-B (CV-B) has been detected in the blood and pancreas of patients with T1D. Notably, viruses can activate HERV-W expression. Hence, we evaluated the effect of CV-B4 infection on HERV-W
Identifiants
pubmed: 32883004
pii: microorganisms8091335
doi: 10.3390/microorganisms8091335
pmc: PMC7563422
pii:
doi:
Types de publication
Journal Article
Langues
eng
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