Targeting Signaling Pathways in Inflammatory Breast Cancer.
clinical trials
inflammatory breast cancer
signaling pathways
targeted therapy
tumor microenvironment
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
01 Sep 2020
01 Sep 2020
Historique:
received:
30
07
2020
revised:
24
08
2020
accepted:
28
08
2020
entrez:
5
9
2020
pubmed:
5
9
2020
medline:
5
9
2020
Statut:
epublish
Résumé
Inflammatory breast cancer (IBC), although rare, is the most aggressive type of breast cancer. Only 2-4% of breast cancer cases are classified as IBC, but-owing to its high rate of metastasis and poor prognosis-8% to 10% of breast cancer-related mortality occur in patients with IBC. Currently, IBC-specific targeted therapies are not available, and there is a critical need for novel therapies derived via understanding novel targets. In this review, we summarize the biological functions of critical signaling pathways in the progression of IBC and the preclinical and clinical studies of targeting these pathways in IBC. We also discuss studies of crosstalk between several signaling pathways and the IBC tumor microenvironment.
Identifiants
pubmed: 32883032
pii: cancers12092479
doi: 10.3390/cancers12092479
pmc: PMC7563157
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : NCI NIH HHS
ID : R01 CA205043
Pays : United States
Organisme : the Emerson Collective Cancer Research Fund
ID : 689199
Organisme : Morgan Welch Inflammatory Breast Cancer Research Program and Clinic, State of Texas Rare and Aggressive Breast Cancer Research Program
ID : N.T.U.
Organisme : NIH HHS
ID : 1R01CA205043-01A1
Pays : United States
Organisme : Breast Cancer Research Foundation
ID : BCRF-17-161
Références
Mol Cancer Res. 2012 Oct;10(10):1306-18
pubmed: 22896661
Oncotarget. 2016 Apr 5;7(14):18531-40
pubmed: 26921265
Oncol Lett. 2017 Feb;13(2):621-628
pubmed: 28356938
Int J Cancer. 2006 Jun 1;118(11):2678-84
pubmed: 16381010
J Biol Chem. 2016 Jun 24;291(26):13715-29
pubmed: 27129239
Breast Cancer Res. 2015 Mar 20;17:42
pubmed: 25887413
Clin Cancer Res. 2004 Oct 15;10(20):6789-95
pubmed: 15501955
Oncogene. 2005 Sep 22;24(42):6406-17
pubmed: 16007195
J Exp Ther Oncol. 2008;7(4):299-312
pubmed: 19227010
Oncotarget. 2017 Jul 4;8(40):67904-67917
pubmed: 28978083
Eur J Cancer. 2009 Jan;45(2):228-47
pubmed: 19097774
J Clin Oncol. 2014 Sep 1;32(25):e88-91
pubmed: 24516025
JAMA Oncol. 2018 Sep 1;4(9):1207-1213
pubmed: 29879283
N Engl J Med. 1991 Jan 3;324(1):1-8
pubmed: 1701519
Cancer Cell. 2010 Sep 14;18(3):207-19
pubmed: 20832749
Science. 2001 Jul 13;293(5528):306-11
pubmed: 11452127
Clin Cancer Res. 2004 Dec 1;10(23):7965-71
pubmed: 15585631
Cancer Res. 2006 Feb 1;66(3):1630-9
pubmed: 16452222
Proc Natl Acad Sci U S A. 2014 May 13;111(19):7084-9
pubmed: 24763687
Breast Cancer Res Treat. 2013 Jan;137(2):471-82
pubmed: 23239151
Br J Cancer. 2007 Oct 22;97(8):1165-74
pubmed: 17848951
Breast Cancer Res Treat. 2014 Jul;146(2):259-72
pubmed: 24916181
Clin Breast Cancer. 2016 Apr;16(2):113-22.e1
pubmed: 26774497
Cancer Res. 2002 Sep 1;62(17):4854-9
pubmed: 12208730
Breast. 2019 Oct;47:56-61
pubmed: 31351202
Cell Mol Life Sci. 2012 May;69(9):1391-414
pubmed: 22076650
Br J Cancer. 2019 Jun;120(12):1105-1112
pubmed: 31097774
Ann Oncol. 2007 Jun;18(6):1021-9
pubmed: 17351259
Clin Cancer Res. 2009 Nov 1;15(21):6639-48
pubmed: 19825949
Breast Cancer Res. 2009;11(5):R77
pubmed: 19874578
Carcinogenesis. 2015 Oct;36(10):1085-93
pubmed: 26354776
Nat Med. 2013 Nov;19(11):1423-37
pubmed: 24202395
Blood. 2013 Oct 3;122(14):2443-52
pubmed: 23982172
Br J Cancer. 2017 Feb 14;116(4):415-423
pubmed: 28072762
Clin Cancer Res. 1999 Sep;5(9):2511-9
pubmed: 10499627
Lancet Oncol. 2009 Jun;10(6):581-8
pubmed: 19394894
Breast Cancer Res. 2004;6(1):R110-5
pubmed: 14696649
Cancer Discov. 2013 Feb;3(2):224-37
pubmed: 23220880
Cancer. 2010 Jun 1;116(11 Suppl):2758-9
pubmed: 20503407
Nature. 2014 Mar 27;507(7493):508-12
pubmed: 24553136
Rheumatology (Oxford). 2019 Mar 1;58(3):536-546
pubmed: 30508140
Blood. 2009 Mar 12;113(11):2470-7
pubmed: 18840707
Cell. 2016 Mar 24;165(1):35-44
pubmed: 26997480
Int J Radiat Oncol Biol Phys. 2018 Mar 15;100(4):1034-1043
pubmed: 29485045
Clin Cancer Res. 2013 Sep 1;19(17):4685-96
pubmed: 23396049
Cancer Res. 2009 Sep 1;69(17):6871-8
pubmed: 19671800
Cancer Cell. 2014 May 12;25(5):605-20
pubmed: 24823638
Cancer. 2011 May 1;117(9):1819-26
pubmed: 21509759
Cancer Res. 2013 Jan 1;73(1):331-40
pubmed: 23117882
J Clin Oncol. 1992 Jun;10(6):1014-24
pubmed: 1588366
Oncogene. 2013 Jul 18;32(29):3420-31
pubmed: 22890323
Hum Pathol. 2010 Mar;41(3):401-6
pubmed: 19913278
Trends Cell Biol. 2005 Mar;15(3):138-45
pubmed: 15752977
Expert Opin Investig Drugs. 2017 Apr;26(4):463-479
pubmed: 28271910
Breast Cancer Res Treat. 2015 Nov;154(1):155-62
pubmed: 26458824
Lancet Oncol. 2016 May;17(5):600-11
pubmed: 27032301
Clin Cancer Res. 2002 Dec;8(12):3857-62
pubmed: 12473600
Cancer Res. 2007 Apr 15;67(8):3878-87
pubmed: 17440102
Nat Cell Biol. 2009 Jul;11(7):903-8
pubmed: 19525934
Ann Oncol. 2014 Feb;25(2):384-91
pubmed: 24351399
Ann Oncol. 2009 May;20(5):862-7
pubmed: 19150933
Breast Cancer Res. 2007;9(5):R61
pubmed: 17875215
J Natl Cancer Inst. 1985 Feb;74(2):291-7
pubmed: 3856043
Cancer J. 2013 Nov-Dec;19(6):502-10
pubmed: 24270349
Clin Cancer Res. 2006 Jun 1;12(11 Pt 1):3249-56
pubmed: 16740744
Cancer Immunol Res. 2019 Jun;7(6):1025-1035
pubmed: 31043414
Oncologist. 2015 Jan;20(1):7-12
pubmed: 25480824
Breast Cancer Res. 2009;11(1):R9
pubmed: 19228416
Cell. 2007 Dec 14;131(6):1124-36
pubmed: 18083102
Lancet Oncol. 2012 Jan;13(1):25-32
pubmed: 22153890
NPJ Breast Cancer. 2016 Nov 02;2:16033
pubmed: 28721387
J Clin Oncol. 2010 Jul 10;28(20):3248-55
pubmed: 20530274
Oncotarget. 2015 Oct 6;6(30):29143-60
pubmed: 26356563
Breast Cancer Res Treat. 2013 Oct;141(3):429-35
pubmed: 24068539
Oncologist. 2020 Jun;25(6):e909-e919
pubmed: 32003919
J Natl Cancer Inst. 2005 Jul 6;97(13):966-75
pubmed: 15998949
Sci Rep. 2016 Dec 19;6:39190
pubmed: 27991524
Lancet. 2010 Jan 30;375(9712):377-84
pubmed: 20113825
Cancer Invest. 2012 May;30(4):287-94
pubmed: 22489801
Int J Cancer. 2002 May 20;99(3):344-51
pubmed: 11992402
Semin Oncol. 2001 Oct;28(5 Suppl 16):4-11
pubmed: 11706390
Cell Death Dis. 2018 Nov 16;9(12):1143
pubmed: 30446635
Nature. 1999 Apr 22;398(6729):723-8
pubmed: 10227296
J Clin Invest. 2008 Dec;118(12):3943-53
pubmed: 19033664
Clin Cancer Res. 2010 Jan 1;16(1):45-55
pubmed: 20028757
Cancer Res. 2013 Nov 1;73(21):6516-25
pubmed: 24014597
Breast Cancer Res Treat. 2005 Oct;93(3):237-46
pubmed: 16172796
J Thromb Haemost. 2005 Aug;3(8):1835-42
pubmed: 16102050
Cancer Res. 2004 Oct 1;64(19):7022-9
pubmed: 15466195
Oncologist. 2012;17(7):891-9
pubmed: 22584436
J Cancer. 2018 Apr 6;9(8):1437-1447
pubmed: 29721054
Am J Pathol. 2002 Aug;161(2):619-28
pubmed: 12163386
Ann Surg Oncol. 2018 Jul;25(7):1783-1785
pubmed: 29671136
Mol Cancer Ther. 2002 Jun;1(8):575-83
pubmed: 12479217
J Clin Invest. 2011 Jul;121(7):2723-35
pubmed: 21633165
Neoplasia. 2000 Sep-Oct;2(5):418-25
pubmed: 11191108
BMC Cancer. 2008 Feb 04;8:41
pubmed: 18248671
BMC Cancer. 2012 Jul 19;12:298
pubmed: 22813402
J Biol Chem. 2006 Dec 8;281(49):37728-37
pubmed: 17035230
Oncogene. 2017 May 4;36(18):2599-2608
pubmed: 27941886
Sci Rep. 2012;2:516
pubmed: 22816039
Lancet Oncol. 2012 Apr;13(4):375-84
pubmed: 22377126
Nat Commun. 2016 Dec 23;7:13898
pubmed: 28008921
Clin Cancer Res. 2014 Jan 1;20(1):164-75
pubmed: 24170546
Cell. 2015 Sep 10;162(6):1257-70
pubmed: 26343581
Cancer Cell. 2013 Nov 11;24(5):631-44
pubmed: 24229710
Breast J. 2010 Sep-Oct;16(5):529-32
pubmed: 20626396
Mol Cancer Res. 2003 Aug;1(10):701-6
pubmed: 12939395