Untangling the origin and function of granulovacuolar degeneration bodies in neurodegenerative proteinopathies.
Granulovacuolar degeneration bodies
Lysosomes
Neurodegenerative proteinopathies
Tau pathology
Journal
Acta neuropathologica communications
ISSN: 2051-5960
Titre abrégé: Acta Neuropathol Commun
Pays: England
ID NLM: 101610673
Informations de publication
Date de publication:
03 09 2020
03 09 2020
Historique:
received:
14
07
2020
accepted:
14
07
2020
entrez:
5
9
2020
pubmed:
5
9
2020
medline:
1
6
2021
Statut:
epublish
Résumé
In the brains of tauopathy patients, tau pathology coincides with the presence of granulovacuolar degeneration bodies (GVBs) both at the regional and cellular level. Recently, it was shown that intracellular tau pathology causes GVB formation in experimental models thus explaining the strong correlation between these neuropathological hallmarks in the human brain. These novel models of GVB formation provide opportunities for future research into GVB biology, but also urge reevaluation of previous post-mortem observations. Here, we review neuropathological data on GVBs in tauopathies and other neurodegenerative proteinopathies. We discuss the possibility that intracellular aggregates composed of proteins other than tau are also able to induce GVB formation. Furthermore, the potential mechanisms of GVB formation and the downstream functional implications hereof are outlined in view of the current available data. In addition, we provide guidelines for the identification of GVBs in tissue and cell models that will help to facilitate and streamline research towards the elucidation of the role of these enigmatic and understudied structures in neurodegeneration.
Identifiants
pubmed: 32883341
doi: 10.1186/s40478-020-00996-5
pii: 10.1186/s40478-020-00996-5
pmc: PMC7469111
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
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