A case of chemotherapy-induced coronary vasospasm in a patient with colorectal cancer.
5-Flourouracil
Bevacizumab
Coronary vasospasm
FOLFOX
Journal
Journal of cardiology cases
ISSN: 1878-5409
Titre abrégé: J Cardiol Cases
Pays: Japan
ID NLM: 101549579
Informations de publication
Date de publication:
Sep 2020
Sep 2020
Historique:
received:
14
01
2020
revised:
29
04
2020
accepted:
08
05
2020
entrez:
5
9
2020
pubmed:
5
9
2020
medline:
5
9
2020
Statut:
epublish
Résumé
Colorectal cancer kills nearly 700,000 people each year worldwide. The use of chemotherapeutic agents in the treatment of colorectal cancer has broadened considerably over the past few decades. The cardiovascular care of patients being treated with these agents has received increasing attention over recent years due to the known cardiovascular toxicities associated with certain treatment regimens, but there may still be unidentified cardiovascular toxicities. Here we present a case of a patient with colorectal cancer without any modifiable cardiovascular risk factors who experienced coronary vasospasm shortly after initiation of therapy with 5-flourouracil, leucovorin, and oxaliplatin with bevacizumab, despite having previously tolerated boluses of 5-flourouracil alone without incident. Coronary vasospasm attributed to this combination of chemotherapy has never before been reported. Additionally, our case and other available literature demonstrate the efficacy of dihydropyridine calcium channel blocker therapy in treatment of vasospasm induced by chemotherapeutic agents. <
Identifiants
pubmed: 32884592
doi: 10.1016/j.jccase.2020.05.014
pii: S1878-5409(20)30051-7
pmc: PMC7452347
doi:
Types de publication
Case Reports
Langues
eng
Pagination
117-120Informations de copyright
© 2020 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.
Références
J Am Coll Cardiol. 2014 Jan 21;63(2):103-9
pubmed: 24201078
Int Heart J. 2017 Oct 21;58(5):803-805
pubmed: 28966326
Circulation. 2016 Mar 29;133(13):1272-89
pubmed: 27022039
J BUON. 2005 Apr-Jun;10(2):205-11
pubmed: 17343330
Acta Oncol. 2010 Apr;49(3):287-97
pubmed: 20156114
Clin Colorectal Cancer. 2016 Jun;15(2):e61-3
pubmed: 26701613
Expert Opin Drug Saf. 2006 Jul;5(4):553-66
pubmed: 16774493
Clin Colorectal Cancer. 2019 Mar;18(1):52-57
pubmed: 30396850
Eur Heart J. 2018 Jan 7;39(2):91-98
pubmed: 29228159
Cardiol J. 2012;19(5):453-8
pubmed: 23042307