Distinct macrophage phenotypes skewed by local granulocyte macrophage colony-stimulating factor (GM-CSF) and macrophage colony-stimulating factor (M-CSF) are associated with tissue destruction and intimal hyperplasia in giant cell arteritis.
giant cell arteritis
granulocyte macrophage colony‐stimulating factor
macrophage colony‐stimulating factor
macrophages
vasculitis
Journal
Clinical & translational immunology
ISSN: 2050-0068
Titre abrégé: Clin Transl Immunology
Pays: Australia
ID NLM: 101638268
Informations de publication
Date de publication:
2020
2020
Historique:
received:
24
03
2020
revised:
10
07
2020
accepted:
11
07
2020
entrez:
5
9
2020
pubmed:
5
9
2020
medline:
5
9
2020
Statut:
epublish
Résumé
To determine the presence and spatial distribution of different macrophage phenotypes, governed by granulocyte macrophage colony-stimulating factor (GM-CSF) and macrophage colony-stimulating factor (M-CSF) skewing signals, in giant cell arteritis (GCA) lesions. Temporal artery biopsies (TABs, A distinct spatial distribution pattern of macrophage phenotypes in TABs was identified. CD206 Our data document a distinct spatial distribution pattern of CD206
Identifiants
pubmed: 32884747
doi: 10.1002/cti2.1164
pii: CTI21164
pmc: PMC7453134
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e1164Informations de copyright
© 2020 The Authors. Clinical & Translational Immunology published by John Wiley & Sons Australia, Ltd on behalf of Australian and New Zealand Society for Immunology Inc.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest. AMHB was a consultant for Grünenthal Gmbh until 2017. EB and KvdG as employees of the UMCG received speaker/consulting fees from Roche which were paid to the UMCG. PH, WHA and EB have received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement 668036.
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