Convalescent plasma for pediatric patients with SARS-CoV-2-associated acute respiratory distress syndrome.
Adolescent
Antibodies, Monoclonal, Humanized
/ therapeutic use
Antibodies, Neutralizing
/ blood
Antibodies, Viral
/ blood
COVID-19
/ complications
Humans
Immunization, Passive
/ methods
Immunoglobulin A
/ blood
Immunoglobulin G
/ blood
Immunoglobulin M
/ blood
Respiratory Distress Syndrome
/ etiology
SARS-CoV-2
/ immunology
Severity of Illness Index
COVID-19 Serotherapy
COVID-19
SARS-CoV-2
convalescent plasma
pediatrics
Journal
Pediatric blood & cancer
ISSN: 1545-5017
Titre abrégé: Pediatr Blood Cancer
Pays: United States
ID NLM: 101186624
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
received:
15
07
2020
revised:
23
08
2020
accepted:
24
08
2020
pubmed:
5
9
2020
medline:
18
12
2020
entrez:
5
9
2020
Statut:
ppublish
Résumé
There are no proven safe and effective therapies for children who develop life-threatening complications of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Convalescent plasma (CP) has demonstrated potential benefit in adults with SARS-CoV-2, but has theoretical risks.We present the first report of CP in children with life-threatening coronavirus disease 2019 (COVID-19), providing data on four pediatric patients with acute respiratory distress syndrome. We measured donor antibody levels and recipient antibody response prior to and following CP infusion. Infusion of CP was not associated with antibody-dependent enhancement (ADE) and did not suppress endogenous antibody response. We found CP was safe and possibly efficacious. Randomized pediatric trials are needed.
Identifiants
pubmed: 32885904
doi: 10.1002/pbc.28693
pmc: PMC7734626
mid: NIHMS1652161
doi:
Substances chimiques
Antibodies, Monoclonal, Humanized
0
Antibodies, Neutralizing
0
Antibodies, Viral
0
Immunoglobulin A
0
Immunoglobulin G
0
Immunoglobulin M
0
tocilizumab
I031V2H011
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e28693Subventions
Organisme : NIAID NIH HHS
ID : K08 AI136660
Pays : United States
Organisme : NIH HHS
ID : UG1CA233249
Pays : United States
Organisme : Children's Hospital of Philadelphia
ID : Immune Dysregulation Frontier Program
Pays : International
Organisme : Clinical Immunology Society
Pays : International
Organisme : NIH HHS
ID : R01A1123538
Pays : United States
Organisme : NIH HHS
ID : X01HD100702
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA193776
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI144472
Pays : United States
Organisme : NIH HHS
ID : R21AI144472
Pays : United States
Organisme : AHRQ HHS
ID : K12 HS026393
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI123433
Pays : United States
Organisme : Team Connor
Pays : International
Organisme : NIH HHS
ID : R01AI121250
Pays : United States
Organisme : NIH HHS
ID : R01AI123433
Pays : United States
Organisme : NIH HHS
ID : T32AI007324
Pays : United States
Organisme : NIH HHS
ID : R01CA193776
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI103280
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI007324
Pays : United States
Organisme : Alex's Lemonade Stand Foundation for Childhood Cancer
Pays : International
Organisme : NIH HHS
ID : K08AI136660
Pays : United States
Organisme : NIH HHS
ID : R01AI103280
Pays : United States
Organisme : NIH HHS
ID : K08AI135091
Pays : United States
Organisme : NIDDK NIH HHS
ID : K23 DK119463
Pays : United States
Organisme : Stand Up To Cancer
Pays : International
Organisme : Cookies for Kids Cancer
Pays : International
Organisme : NIAID NIH HHS
ID : K08 AI135091
Pays : United States
Organisme : American Academy of Allergy Asthma and Immunology
Pays : International
Organisme : Leukemia and Lymphoma Society
Pays : International
Organisme : Burroughs Wellcome Fund
Pays : International
Organisme : NIAID NIH HHS
ID : R01 AI121250
Pays : United States
Organisme : NCI NIH HHS
ID : UG1 CA233249
Pays : United States
Organisme : Kate Amato Foundation
Pays : International
Organisme : NIH HHS
ID : K12HS026393
Pays : United States
Organisme : University of Pennsylvania
Pays : International
Organisme : Children's Oncology Group
Pays : International
Informations de copyright
© 2020 Wiley Periodicals LLC.
Références
Nat Med. 2020 Jul;26(7):1033-1036
pubmed: 32398876
Sci Immunol. 2020 Jun 11;5(48):
pubmed: 32527802
J Infect Dis. 2004 Jul 15;190(2):379-86
pubmed: 15216476
N Engl J Med. 2020 Apr 2;382(14):1370-1371
pubmed: 32163697
Biochem Biophys Res Commun. 2014 Aug 22;451(2):208-14
pubmed: 25073113
Chest. 2020 Jul;158(1):e9-e13
pubmed: 32243945
Emerg Infect Dis. 2020 Jul;26(7):1478-1488
pubmed: 32267220
JAMA. 2020 Aug 4;324(5):460-470
pubmed: 32492084
J Clin Invest. 2020 Nov 2;130(11):5967-5975
pubmed: 32730233
J Clin Invest. 2020 Jun 1;130(6):2757-2765
pubmed: 32254064
JAMA Pediatr. 2020 Oct 1;174(10):e202430
pubmed: 32492092
J Clin Invest. 2020 Sep 1;130(9):4791-4797
pubmed: 32525844
Sci Immunol. 2020 Jul 29;5(49):
pubmed: 32727884
JAMA. 2020 Apr 28;323(16):1582-1589
pubmed: 32219428
Virol J. 2014 May 06;11:82
pubmed: 24885320
J Pediatr. 2020 Aug;223:14-19.e2
pubmed: 32407719
Cell Rep. 2020 Jun 2;31(9):107725
pubmed: 32426212
Lancet. 2020 Feb 15;395(10223):497-506
pubmed: 31986264
Proc Natl Acad Sci U S A. 2020 Apr 28;117(17):9490-9496
pubmed: 32253318
Hum Vaccin Immunother. 2016 Sep;12(9):2351-6
pubmed: 27269431