COVID-19 outbreak: history, mechanism, transmission, structural studies and therapeutics.
COVID-19
Coronavirus
Epidemiology
Intrinsic disorder region
SARS-CoV
SARS-CoV-2 therapeutics
Spike protein
Journal
Infection
ISSN: 1439-0973
Titre abrégé: Infection
Pays: Germany
ID NLM: 0365307
Informations de publication
Date de publication:
Apr 2021
Apr 2021
Historique:
received:
06
07
2020
accepted:
25
08
2020
pubmed:
5
9
2020
medline:
7
4
2021
entrez:
5
9
2020
Statut:
ppublish
Résumé
The coronavirus outbreak emerged as a severe pandemic, claiming more than 0.8 million lives across the world and raised a major global health concern. We survey the history and mechanism of coronaviruses, and the structural characteristics of the spike protein and its key residues responsible for human transmissions. We have carried out a systematic review to summarize the origin, transmission and etiology of COVID-19. The structural analysis of the spike protein and its disordered residues explains the mechanism of the viral transmission. A meta-data analysis of the therapeutic compounds targeting the SARS-CoV-2 is also included. Coronaviruses can cross the species barrier and infect humans with unexpected consequences for public health. The transmission rate of SARS-CoV-2 infection is higher compared to that of the closely related SARS-CoV infections. In SARS-CoV-2 infection, intrinsically disordered regions are observed at the interface of the spike protein and ACE2 receptor, providing a shape complementarity to the complex. The key residues of the spike protein have stronger binding affinity with ACE2. These can be probable reasons for the higher transmission rate of SARS-CoV-2. In addition, we have also discussed the therapeutic compounds and the vaccines to target SARS-CoV-2, which can help researchers to develop effective drugs/vaccines for COVID-19. The overall history and mechanism of entry of SARS-CoV-2 along with structural study of spike-ACE2 complex provide insights to understand disease pathogenesis and development of vaccines and drugs.
Identifiants
pubmed: 32886331
doi: 10.1007/s15010-020-01516-2
pii: 10.1007/s15010-020-01516-2
pmc: PMC7472674
doi:
Substances chimiques
Spike Glycoprotein, Coronavirus
0
spike protein, SARS-CoV-2
0
Types de publication
Journal Article
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
199-213Subventions
Organisme : Department of Science and Technology, Ministry of Science and Technology
ID : MSC/2020/000319
Références
Naunyn Schmiedebergs Arch Pharmacol. 1992 Sep;346(3):262-6
pubmed: 1407012
J Med Chem. 2018 Apr 26;61(8):3516-3540
pubmed: 29526098
Transl Pediatr. 2020 Feb;9(1):51-60
pubmed: 32154135
Can J Anaesth. 2020 Oct;67(10):1424-1430
pubmed: 32488493
J Virol. 2010 Apr;84(7):3134-46
pubmed: 19906932
Clin Infect Dis. 2005 Jun 15;40(12):1721-9
pubmed: 15909257
Nature. 2020 Mar;579(7798):270-273
pubmed: 32015507
Science. 2020 Mar 13;367(6483):1260-1263
pubmed: 32075877
Viruses. 2020 May 10;12(5):
pubmed: 32397688
Eur J Med Chem. 2012 Jan;47(1):345-50
pubmed: 22115617
J Med Chem. 2012 Oct 11;55(19):8211-24
pubmed: 22784008
J Med Virol. 2020 Sep;92(9):1580-1586
pubmed: 32249956
Lancet. 2020 Feb 15;395(10223):514-523
pubmed: 31986261
Cell. 2018 Dec 13;175(7):1931-1945.e18
pubmed: 30550790
ACS Med Chem Lett. 2010 Oct 8;2(1):39-42
pubmed: 21874153
Mol Oncol. 2018 Jan;12(1):74-88
pubmed: 29112787
Front Immunol. 2020 Jun 05;11:1312
pubmed: 32582222
Cancer Res. 2010 Dec 15;70(24):10288-98
pubmed: 21159648
Mol Cancer Ther. 2006 Jul;5(7):1807-16
pubmed: 16891467
J Clin Invest. 2003 Jun;111(11):1605-9
pubmed: 12782660
J Biol Chem. 1990 Mar 25;265(9):5267-72
pubmed: 2156866
N Engl J Med. 2020 Mar 26;382(13):1199-1207
pubmed: 31995857
Antiviral Res. 2013 Dec;100(3):605-14
pubmed: 24121034
Antimicrob Agents Chemother. 2005 Sep;49(9):3896-902
pubmed: 16127068
J Virol. 2015 Jul;89(14):7202-13
pubmed: 25926653
JAMA. 2020 Feb 25;323(8):709-710
pubmed: 31999307
Cell Res. 2017 Jan;27(1):119-129
pubmed: 28008928
Biochem J. 2013 Jun 1;452(2):331-43
pubmed: 23527573
Curr Mol Med. 2005 Nov;5(7):677-97
pubmed: 16305493
Clin Microbiol Rev. 2007 Oct;20(4):660-94
pubmed: 17934078
J Med Chem. 2016 Feb 11;59(3):1140-1148
pubmed: 26771665
JAMA. 2020 Mar 17;323(11):1061-1069
pubmed: 32031570
Cell Res. 2020 Mar;30(3):269-271
pubmed: 32020029
Nature. 2013 Jul 25;499(7459):388
pubmed: 23887408
J Med Chem. 2008 Sep 25;51(18):5490-3
pubmed: 18720984
N Engl J Med. 2020 Apr 30;382(18):1708-1720
pubmed: 32109013
Neuropharmacology. 1997 Jan;36(1):51-62
pubmed: 9144641
Nat Rev Mol Cell Biol. 2005 Mar;6(3):197-208
pubmed: 15738986
Int J Biol Sci. 2020 Mar 15;16(10):1724-1731
pubmed: 32226290
J Med Chem. 2019 Jun 27;62(12):5863-5884
pubmed: 31070916
Lancet Respir Med. 2020 Jul;8(7):658-659
pubmed: 32473123
Viruses. 2014 Aug 07;6(8):2991-3018
pubmed: 25105276
Bioorg Med Chem Lett. 2012 Dec 1;22(23):7169-73
pubmed: 23099093
J Med Chem. 2010 Oct 28;53(20):7428-40
pubmed: 20873792
Nat Rev Drug Discov. 2016 May;15(5):327-47
pubmed: 26868298
N Engl J Med. 2012 Nov 8;367(19):1814-20
pubmed: 23075143
Annu Rev Virol. 2016 Sep 29;3(1):237-261
pubmed: 27578435
Lancet. 2020 Feb 15;395(10223):e30-e31
pubmed: 32032529
J Med Chem. 2017 Mar 9;60(5):2148-2154
pubmed: 28145708
Trials. 2018 Jan 30;19(1):81
pubmed: 29382391
PLoS Pathog. 2017 Nov 30;13(11):e1006698
pubmed: 29190287
J Med Chem. 2007 Mar 8;50(5):951-61
pubmed: 17328523
J Med Chem. 2018 Nov 8;61(21):9473-9499
pubmed: 30074795
J Virol. 2012 Jun;86(12):6537-45
pubmed: 22496216
Trends Microbiol. 2004 Oct;12(10):466-72
pubmed: 15381196
Elife. 2015 Dec 10;4:
pubmed: 26651998
J Med Chem. 2016 Feb 25;59(4):1330-9
pubmed: 26815195
Nature. 2013 Nov 28;503(7477):535-8
pubmed: 24172901
Antiviral Res. 2013 Oct;100(1):246-54
pubmed: 23994189
J Virol. 2015 Feb;89(4):1954-64
pubmed: 25428871
J Biol Chem. 2007 Oct 26;282(43):31542-8
pubmed: 17646169
ACS Med Chem Lett. 2017 Jan 17;8(2):157-162
pubmed: 28197304
Mol Pharmacol. 1997 Jun;51(6):1070-6
pubmed: 9187274
Vet Res. 1993;24(2):125-50
pubmed: 8393722
Virus Res. 2015 Apr 16;202:120-34
pubmed: 25445340
Virus Res. 2005 Jan;107(1):93-101
pubmed: 15567038
J Virol. 2019 Feb 5;93(4):
pubmed: 30541831
Viruses. 2020 Jan 24;12(2):
pubmed: 31991541
Nature. 2016 Mar 3;531(7592):118-21
pubmed: 26935699
Risk Anal. 2020 May;40(5):902-907
pubmed: 32356927
J Vet Diagn Invest. 2013 Sep;25(5):649-54
pubmed: 23963154
Nature. 2009 Apr 9;458(7239):732-6
pubmed: 19360080
Nat Rev Drug Discov. 2020 May;19(5):305-306
pubmed: 32273591
J Med Chem. 2016 Mar 10;59(5):1830-9
pubmed: 26885694
Biochem Biophys Res Commun. 1998 Jun 29;247(3):859-63
pubmed: 9647783
Antiviral Res. 2018 Feb;150:112-122
pubmed: 29253498
One Health. 2020 Dec;10:100133
pubmed: 32363229
J Virol. 2020 Mar 17;94(7):
pubmed: 31996437
Int J Environ Res Public Health. 2020 Apr 23;17(8):
pubmed: 32340347
Nature. 1969 Aug 23;223(5208):848-50
pubmed: 5799033
Antiviral Res. 2014 Mar;103:39-50
pubmed: 24418573
J Pathol. 2004 Jun;203(2):631-7
pubmed: 15141377
J Med Chem. 2011 Jan 27;54(2):635-54
pubmed: 21174434
J Virol. 2011 Jul;85(13):6381-9
pubmed: 21507972
Antimicrob Agents Chemother. 2016 Oct 21;60(11):6532-6539
pubmed: 27550352
Immunopharmacology. 2000 May;47(2-3):163-84
pubmed: 10878288
Biochem J. 2008 Jan 15;409(2):581-9
pubmed: 17868033
Nat Microbiol. 2020 Apr;5(4):562-569
pubmed: 32094589
Ann Intern Med. 2020 Jun 2;172(11):754-755
pubmed: 32232419
Nat Biotechnol. 2011 Oct 30;29(11):1046-51
pubmed: 22037378
Front Pharmacol. 2018 Jul 10;9:711
pubmed: 30042674
Nature. 2017 May 4;545(7652):112-115
pubmed: 28445455
Antiviral Res. 2018 Jul;155:67-75
pubmed: 29753658
Nat Biotechnol. 2008 Jan;26(1):127-32
pubmed: 18183025
EMBO J. 2001 Dec 17;20(24):6969-78
pubmed: 11742974
Nature. 2020 Feb;578(7794):306-310
pubmed: 31969702
Cell Res. 2008 Feb;18(2):290-301
pubmed: 18227861
Virol J. 2005 Aug 22;2:69
pubmed: 16115318
Nat Biotechnol. 2020 May;38(5):523-532
pubmed: 32203293
Nat Rev Microbiol. 2009 Jun;7(6):439-50
pubmed: 19430490
ACS Chem Biol. 2015 Aug 21;10(8):1770-7
pubmed: 26035625
Antiviral Res. 2020 Apr;176:104742
pubmed: 32057769
J Biol Chem. 2006 Feb 10;281(6):3198-203
pubmed: 16339146
Virol J. 2009 Jun 03;6:69
pubmed: 19493338
Elife. 2014 May 13;3:e02242
pubmed: 24843020
Nat Microbiol. 2020 Apr;5(4):536-544
pubmed: 32123347
Lancet. 2020 Feb 15;395(10223):497-506
pubmed: 31986264
EMBO J. 2003 Jul 1;22(13):3411-20
pubmed: 12840003
Science. 2020 Mar 27;367(6485):1444-1448
pubmed: 32132184
Bioorg Med Chem Lett. 2017 Aug 1;27(15):3219-3225
pubmed: 28655422
Biochemistry. 2004 May 25;43(20):6059-63
pubmed: 15147189
BMC Infect Dis. 2012 Dec 20;12:365
pubmed: 23256846
J Biomol Struct Dyn. 2021 Apr;39(7):2673-2678
pubmed: 32248766
J Biomol Struct Dyn. 2021 May;39(8):3025-3033
pubmed: 32274964
J Biol Chem. 2004 Mar 12;279(11):10136-41
pubmed: 14699140
Proc Natl Acad Sci U S A. 2018 May 29;115(22):E5086-E5095
pubmed: 29764999
Pediatr Infect Dis J. 2013 Apr;32(4):325-9
pubmed: 23337903
Nat New Biol. 1971 Jun 23;231(25):232-5
pubmed: 5284360
Eur J Clin Pharmacol. 1998 May;54(3):215-9
pubmed: 9681662
Curr Top Med Chem. 2020;20(24):2210-2220
pubmed: 32648845
Cell Rep. 2017 Jan 10;18(2):432-442
pubmed: 28076787
Lancet. 2020 Feb 15;395(10223):507-513
pubmed: 32007143
Bioorg Med Chem Lett. 2012 Jun 1;22(11):3727-31
pubmed: 22560567
PLoS One. 2013 Dec 31;8(12):e83190
pubmed: 24391744
Emerg Infect Dis. 2005 Dec;11(12):1860-5
pubmed: 16485471
Biochem Biophys Res Commun. 2005 Jun 24;332(1):304-10
pubmed: 15896331
Nat Med. 2004 Dec;10(12 Suppl):S88-97
pubmed: 15577937
Nature. 2003 Jan 30;421(6922):551-4
pubmed: 12540854
Curr Med Chem. 2011;18(20):2995-3014
pubmed: 21651476
Int J Biol Macromol. 2020 May 1;150:705-713
pubmed: 32057853
Nature. 2020 Jul;583(7816):459-468
pubmed: 32353859
Nat Med. 2019 Feb;25(2):301-311
pubmed: 30643286
Signal Transduct Target Ther. 2020 Jun 12;5(1):92
pubmed: 32532959
Clin Exp Immunol. 2004 Apr;136(1):95-103
pubmed: 15030519
N Engl J Med. 2020 Mar 5;382(10):970-971
pubmed: 32003551
Cell. 2020 May 14;181(4):894-904.e9
pubmed: 32275855
Immunity. 2020 Apr 14;52(4):583-589
pubmed: 32259480
Eur J Biochem. 2000 Jul;267(13):4179-86
pubmed: 10866822