Circulating metabolites are associated with brain atrophy and white matter hyperintensities.
Alzheimer's disease
cholesterol
glucose
lipids
magnetic resonance imaging (MRI)
metabolism
Journal
Alzheimer's & dementia : the journal of the Alzheimer's Association
ISSN: 1552-5279
Titre abrégé: Alzheimers Dement
Pays: United States
ID NLM: 101231978
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
received:
16
10
2019
revised:
25
07
2020
accepted:
08
08
2020
pubmed:
5
9
2020
medline:
16
11
2021
entrez:
5
9
2020
Statut:
ppublish
Résumé
Our aim was to study whether systemic metabolites are associated with magnetic resonance imaging (MRI) measures of brain and hippocampal atrophy and white matter hyperintensities (WMH). We studied associations of 143 plasma-based metabolites with MRI measures of brain and hippocampal atrophy and WMH in three independent cohorts (n = 3962). We meta-analyzed the results of linear regression analyses to determine the association of metabolites with MRI measures. Higher glucose levels and lower levels of three small high density lipoprotein (HDL) particles were associated with brain atrophy. Higher glucose levels were associated with WMH. Glucose levels were associated with brain atrophy and WMH, and small HDL particle levels were associated with brain atrophy. Circulating metabolites may aid in developing future intervention trials.
Identifiants
pubmed: 32886448
doi: 10.1002/alz.12180
pmc: PMC7984157
doi:
Substances chimiques
Blood Glucose
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
205-214Informations de copyright
© 2020 The Authors. Alzheimer's & Dementia published by Wiley Periodicals, Inc. on behalf of Alzheimer's Association.
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