Short-Chain Fatty Acids and Their Association with Signalling Pathways in Inflammation, Glucose and Lipid Metabolism.
glycose and lipid metabolism
inflammation
short-chain fatty acids
signalling pathways
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
02 Sep 2020
02 Sep 2020
Historique:
received:
11
07
2020
revised:
20
08
2020
accepted:
27
08
2020
entrez:
5
9
2020
pubmed:
6
9
2020
medline:
26
3
2021
Statut:
epublish
Résumé
Short-chain fatty acids (SCFAs), particularly acetate, propionate and butyrate, are mainly produced by anaerobic fermentation of gut microbes. SCFAs play an important role in regulating energy metabolism and energy supply, as well as maintaining the homeostasis of the intestinal environment. In recent years, many studies have shown that SCFAs demonstrate physiologically beneficial effects, and the signalling pathways related to SCFA production, absorption, metabolism, and intestinal effects have been discovered. Two major signalling pathways concerning SCFAs, G-protein-coupled receptors (GPRCs) and histone deacetylases (HDACs), are well recognized. In this review, we summarize the recent advances concerning the biological properties of SCFAs and the signalling pathways in inflammation and glucose and lipid metabolism.
Identifiants
pubmed: 32887215
pii: ijms21176356
doi: 10.3390/ijms21176356
pmc: PMC7503625
pii:
doi:
Substances chimiques
Fatty Acids, Volatile
0
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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