Proteomic Characterization of the Olfactory Molecular Imbalance in Dementia with Lewy Bodies.
Lewy bodies
dementia
olfaction
olfactory bulb
proteomics
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
02 Sep 2020
02 Sep 2020
Historique:
received:
29
07
2020
revised:
18
08
2020
accepted:
01
09
2020
entrez:
5
9
2020
pubmed:
6
9
2020
medline:
26
3
2021
Statut:
epublish
Résumé
Olfactory dysfunction is one of the prodromal symptoms in dementia with Lewy bodies (DLB). However, the molecular pathogenesis associated with decreased smell function remains largely undeciphered. We generated quantitative proteome maps to detect molecular alterations in olfactory bulbs (OB) derived from DLB subjects compared to neurologically intact controls. A total of 3214 olfactory proteins were quantified, and 99 proteins showed significant alterations in DLB cases. Protein interaction networks disrupted in DLB indicated an imbalance in translation and the synaptic vesicle cycle. These alterations were accompanied by alterations in AKT/MAPK/SEK1/p38 MAPK signaling pathways that showed a distinct expression profile across the OB-olfactory tract (OT) axis. Taken together, our data partially reflect the missing links in the biochemical understanding of olfactory dysfunction in DLB.
Identifiants
pubmed: 32887355
pii: ijms21176371
doi: 10.3390/ijms21176371
pmc: PMC7503830
pii:
doi:
Substances chimiques
Biomarkers
0
Proteome
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Spanish Ministry of Economy and Competitiveness
ID : SAF2014-59340-R
Organisme : Spanish Ministry of Science Innovation and Universities
ID : PID2019-110356RB-I00
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