cGAS-STING pathway in cancer biotherapy.
Agonist
Cancer biotherapy
Clinical trials
Cyclic dinucleotide
Delivery system
Interferon
cGAS-STING pathway
Journal
Molecular cancer
ISSN: 1476-4598
Titre abrégé: Mol Cancer
Pays: England
ID NLM: 101147698
Informations de publication
Date de publication:
04 09 2020
04 09 2020
Historique:
received:
22
06
2020
accepted:
12
08
2020
entrez:
5
9
2020
pubmed:
6
9
2020
medline:
12
6
2021
Statut:
epublish
Résumé
The activation of the cGAS-STING pathway has tremendous potential to improve anti-tumor immunity by generating type I interferons. In recent decades, we have witnessed that producing dsDNA upon various stimuli is an initiative factor, triggering the cGAS-SING pathway for a defensive host. The understanding of both intracellular cascade reaction and the changes of molecular components gains insight into type I IFNs and adaptive immunity. Based on the immunological study, the STING-cGAS pathway is coupled to cancer biotherapy. The most challenging problem is the limited therapeutic effect. Therefore, people view 5, 6-dimethylxanthenone-4-acetic acid, cyclic dinucleotides and various derivative as cGAS-STING pathway agonists. Even so, these agonists have flaws in decreasing biotherapeutic efficacy. Subsequently, we exploited agonist delivery systems (nanocarriers, microparticles and hydrogels). The article will discuss the activation of the cGAS-STING pathway and underlying mechanisms, with an introduction of cGAS-STING agonists, related clinical trials and agonist delivery systems.
Identifiants
pubmed: 32887628
doi: 10.1186/s12943-020-01247-w
pii: 10.1186/s12943-020-01247-w
pmc: PMC7472700
doi:
Substances chimiques
Interferon Type I
0
Membrane Proteins
0
STING1 protein, human
0
Xanthines
0
methylxanthine
28109-92-4
Nucleotidyltransferases
EC 2.7.7.-
cGAS protein, human
EC 2.7.7.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
136Références
J Exp Med. 2007 Jul 9;204(7):1559-69
pubmed: 17562815
Nat Immunol. 2019 Aug;20(8):1035-1045
pubmed: 31235953
Nat Commun. 2017 Sep 5;8(1):427
pubmed: 28874664
Cancer Discov. 2020 Mar;10(3):382-393
pubmed: 31974171
Sci Transl Med. 2015 Apr 15;7(283):283ra52
pubmed: 25877890
Mol Cell Proteomics. 2009 Jun;8(6):1278-94
pubmed: 19329653
Cell Rep. 2015 May 19;11(7):1018-30
pubmed: 25959818
Nat Med. 2014 Nov;20(11):1301-9
pubmed: 25344738
J Clin Oncol. 2011 Aug 1;29(22):2965-71
pubmed: 21709202
Signal Transduct Target Ther. 2018 Mar 16;3:7
pubmed: 29560283
J Virol. 2019 Feb 5;93(4):
pubmed: 30463976
Org Biomol Chem. 2019 Feb 13;17(7):1869-1874
pubmed: 30117503
Cancer Discov. 2019 Sep;9(9):1208-1227
pubmed: 31217296
J Immunol. 2011 May 1;186(9):5142-50
pubmed: 21441457
JAMA. 2018 Sep 4;320(9):858-860
pubmed: 30140852
Nat Rev Immunol. 2020 Feb;20(2):128-136
pubmed: 31591533
Lung Cancer. 2009 Aug;65(2):192-7
pubmed: 19409645
Cell Host Microbe. 2013 Oct 16;14(4):422-34
pubmed: 24139400
Ann Rheum Dis. 2017 Feb;76(2):468-472
pubmed: 27566796
Nat Rev Cancer. 2019 Oct;19(10):587-602
pubmed: 31492927
Immunity. 2018 Oct 16;49(4):754-763.e4
pubmed: 30332631
Lancet. 2019 Nov 23;394(10212):1884-1885
pubmed: 31590987
Nat Immunol. 2019 Feb;20(2):152-162
pubmed: 30643259
Cell. 2013 Aug 29;154(5):962-970
pubmed: 23993090
JCI Insight. 2018 Oct 18;3(20):
pubmed: 30333318
Trends Immunol. 2015 Mar;36(3):139-49
pubmed: 25687684
Oncol Res. 2002;13(2):95-101
pubmed: 12392157
Cancer Immunol Res. 2014 Sep;2(9):901-10
pubmed: 24913717
FEBS J. 2020 Jan;287(1):205-217
pubmed: 31365788
Nat Commun. 2019 Nov 8;10(1):5108
pubmed: 31704921
Blood. 2009 Oct 29;114(18):3864-71
pubmed: 19710501
Semin Cancer Biol. 2019 Nov 4;:
pubmed: 31698088
Biomaterials. 2018 May;163:67-75
pubmed: 29454236
Nat Commun. 2018 Jul 17;9(1):2770
pubmed: 30018345
Cancer Chemother Pharmacol. 2007 Apr;59(5):681-7
pubmed: 17021822
J Control Release. 2018 Jan 28;270:1-13
pubmed: 29170142
J Immunol. 2015 Sep 1;195(5):1909-10
pubmed: 26297789
Immunity. 2014 Nov 20;41(5):843-52
pubmed: 25517616
Blood. 2011 Aug 18;118(7):1877-84
pubmed: 21680794
Nat Commun. 2017 Oct 6;8(1):793
pubmed: 28986561
Front Immunol. 2012 Mar 14;3:41
pubmed: 22566924
Nature. 2018 Dec;564(7736):439-443
pubmed: 30405246
Vaccine. 2013 Apr 26;31(18):2310-6
pubmed: 23473776
Br J Cancer. 2002 Jun 17;86(12):1937-42
pubmed: 12085190
Nature. 2013 Jun 20;498(7454):380-4
pubmed: 23722158
DNA Repair (Amst). 2008 Jun 1;7(6):997-1003
pubmed: 18406216
Cancer Immunol Immunother. 2015 Aug;64(8):1057-66
pubmed: 25986168
Nature. 2012 Feb 08;482(7385):405-9
pubmed: 22318517
BioDrugs. 1997 Aug;8(2):119-27
pubmed: 18020500
Cell Rep. 2018 Dec 11;25(11):3074-3085.e5
pubmed: 30540940
J Immunother Cancer. 2019 Oct 18;7(1):267
pubmed: 31627733
Nat Rev Cancer. 2017 Jan;17(1):20-37
pubmed: 27834398
Cancer Immunol Immunother. 2017 Jun;66(6):705-716
pubmed: 28243692
Oncoimmunology. 2013 Sep 1;2(9):e26246
pubmed: 24319640
Nat Commun. 2012;3:1282
pubmed: 23250412
Gastroenterology. 2018 Dec;155(6):1971-1984.e4
pubmed: 30213555
Nature. 2017 Aug 24;548(7668):461-465
pubmed: 28738408
Biomaterials. 2019 Jun;205:94-105
pubmed: 30909112
Acta Biomater. 2016 Jan;29:271-281
pubmed: 26485167
Nat Rev Immunol. 2019 Nov;19(11):688-701
pubmed: 31213673
Nat Commun. 2018 Mar 28;9(1):1249
pubmed: 29593264
N Engl J Med. 2019 Aug 1;381(5):455-464
pubmed: 31365802
Curr Opin Immunol. 2019 Feb;56:24-30
pubmed: 30292848
Front Immunol. 2019 Mar 28;10:582
pubmed: 30984174
Cancer Cell. 2014 Nov 10;26(5):638-52
pubmed: 25446897
Sci Transl Med. 2018 Mar 21;10(433):
pubmed: 29563317
Nat Rev Genet. 2019 Nov;20(11):657-674
pubmed: 31358977
Br J Cancer. 2008 Dec 16;99(12):2006-12
pubmed: 19078952
Blood. 2003 Nov 1;102(9):3100-7
pubmed: 12855576
Theranostics. 2018 May 10;8(12):3198-3213
pubmed: 29930723
Lancet Oncol. 2002 Jan;3(1):17-26
pubmed: 11905600
Oncogene. 2019 Mar;38(13):2380-2393
pubmed: 30518877
Neuron. 2017 Dec 20;96(6):1290-1302.e6
pubmed: 29268096
Nat Chem Biol. 2014 Dec;10(12):1043-8
pubmed: 25344812
JCI Insight. 2018 Nov 15;3(22):
pubmed: 30429378
Leukemia. 2002 Oct;16(10):2046-54
pubmed: 12357356
CA Cancer J Clin. 2019 Nov;69(6):435-437
pubmed: 31545880
Nat Nanotechnol. 2017 Jul;12(7):648-654
pubmed: 28436963
Nat Nanotechnol. 2019 Mar;14(3):269-278
pubmed: 30664751
Sci Rep. 2016 Jan 12;6:19049
pubmed: 26754564
J Clin Oncol. 2005 Dec 10;23(35):8992-9000
pubmed: 16260693
J Control Release. 2014 Jun 28;184:20-7
pubmed: 24727060
Cancer Cell. 2011 Dec 13;20(6):781-96
pubmed: 22172723
Cell. 2017 Sep 7;170(6):1109-1119.e10
pubmed: 28886381
Proc Natl Acad Sci U S A. 2015 Dec 15;112(50):15408-13
pubmed: 26607445
Nature. 2016 May 18;533(7604):493-498
pubmed: 27225120
Bioorg Med Chem Lett. 2019 Oct 15;29(20):126640
pubmed: 31500996
Cancer Immunol Res. 2015 Feb;3(2):196-205
pubmed: 25477253
Adv Biosyst. 2017 Feb;1(1-2):
pubmed: 30258983
PLoS One. 2014 Jun 09;9(6):e98464
pubmed: 24911414
Cancer Chemother Pharmacol. 1995;36(2):143-8
pubmed: 7767951
J Clin Invest. 2017 Jun 1;127(6):2176-2191
pubmed: 28436934
Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1637-1642
pubmed: 28137885
Nat Med. 2018 Aug;24(8):1277-1289
pubmed: 29988129
Cell Metab. 2019 Oct 1;30(4):784-799.e5
pubmed: 31474566
Oncogene. 2014 Apr 17;33(16):2123-33
pubmed: 23644655
Molecules. 2019 Nov 19;24(22):
pubmed: 31752288
J Clin Invest. 2015 Jun;125(6):2532-46
pubmed: 25938786
Immunol Cell Biol. 2012 May;90(5):492-7
pubmed: 22391814
J Neurosci. 2019 Aug 7;39(32):6378-6394
pubmed: 31189575
Biomater Sci. 2019 Aug 1;7(8):3386-3403
pubmed: 31233057
Cancer Res. 2019 Jan 15;79(2):311-319
pubmed: 30482774
Cancer Res. 2018 Nov 1;78(21):6308-6319
pubmed: 30224374
Int J Pharm. 2020 Mar 30;578:119127
pubmed: 32036009
Science. 2015 Sep 11;349(6253):1228-32
pubmed: 26229117
J Clin Invest. 2019 Aug 13;129(11):4850-4862
pubmed: 31408442
J Exp Med. 2017 Jun 5;214(6):1769-1785
pubmed: 28484079
Immunol Rev. 2017 Mar;276(1):121-144
pubmed: 28258700
Cell Res. 2017 Jan;27(1):96-108
pubmed: 27981969
Cell Rep. 2018 Dec 11;25(11):2972-2980.e5
pubmed: 30540933
Oncoimmunology. 2015 May 27;4(8):e1017704
pubmed: 26405568
Gut. 2010 Jul;59(7):926-33
pubmed: 20581241
Mol Pharm. 2018 Nov 5;15(11):4933-4946
pubmed: 30281314