TGFβ1 Induces Axonal Outgrowth via ALK5/PKA/SMURF1-Mediated Degradation of RhoA and Stabilization of PAR6.

Adaptor Proteins, Signal Transducing Animals Cyclic AMP-Dependent Protein Kinases Humans Mice Neuronal Outgrowth Phosphorylation Receptor, Transforming Growth Factor-beta Type I Recovery of Function Signal Transduction Transforming Growth Factor beta1 Ubiquitin-Protein Ligases rhoA GTP-Binding Protein
downstream signaling neurite outgrowth plasticity stroke tgfb1

Journal

eNeuro
ISSN: 2373-2822
Titre abrégé: eNeuro
Pays: United States
ID NLM: 101647362

Informations de publication

Date de publication:
Historique:
received: 17 03 2020
revised: 21 07 2020
accepted: 06 08 2020
pubmed: 6 9 2020
medline: 22 6 2021
entrez: 5 9 2020
Statut: epublish

Résumé

Transforming growth factor (TGF)β1 has repeatedly been associated with axonal regeneration and recovery after injury to the CNS. We found TGFβ1 upregulated in the stroke-denervated mouse spinal cord after ischemic injury to the motor cortex as early as 4 d postinjury (dpi) and persisting up to 28 dpi. Given the potential role of TGFβ1 in structural plasticity and functional recovery after stroke highlighted in several published studies, we investigated its downstream signaling in an

Identifiants

DOI: 10.1523/ENEURO.0104-20.2020 PMID: 32887692 PMC: PMC7540929
pubmed: 32887692
pii: ENEURO.0104-20.2020
doi: 10.1523/ENEURO.0104-20.2020
pmc: PMC7540929
pii:
doi:

Substances chimiques

Adaptor Proteins, Signal Transducing 0
PARD6A protein, human 0
TGFB1 protein, human 0
Transforming Growth Factor beta1 0
RHOA protein, human 124671-05-2
SMURF1 protein, human EC 2.3.2.26
Ubiquitin-Protein Ligases EC 2.3.2.27
Cyclic AMP-Dependent Protein Kinases EC 2.7.11.11
Receptor, Transforming Growth Factor-beta Type I EC 2.7.11.30
TGFBR1 protein, human EC 2.7.11.30
rhoA GTP-Binding Protein EC 3.6.5.2

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright © 2020 Kaiser et al.

Références

Brain Res. 1996 Jun 3;723(1-2):206-9
pubmed: 8813400
J Neurosci. 2007 Aug 29;27(35):9458-68
pubmed: 17728459
Stem Cell Reports. 2017 Aug 8;9(2):667-680
pubmed: 28712846
Methods Mol Biol. 2015;1294:137-50
pubmed: 25783883
J Cell Biol. 2007 Jan 1;176(1):35-42
pubmed: 17190792
Neuroreport. 2014 Mar 26;25(5):340-6
pubmed: 24535220
Neuroscience. 2001;107(4):593-602
pubmed: 11720783
Neurobiol Dis. 2010 Jun;38(3):395-404
pubmed: 20211260
Trends Cell Biol. 2009 Aug;19(8):385-94
pubmed: 19648010
Exp Neurol. 2000 Feb;161(2):664-75
pubmed: 10686085
Nat Commun. 2013;4:2690
pubmed: 24162165
J Cell Sci. 2015 Jul 15;128(14):2403-14
pubmed: 26116576
Science. 2005 Mar 11;307(5715):1603-9
pubmed: 15761148
J Neurosci. 2008 Feb 20;28(8):1961-9
pubmed: 18287512
Cell. 2009 Apr 17;137(2):295-307
pubmed: 19379695
Curr Opin Neurol. 2011 Dec;24(6):577-83
pubmed: 21968547
J Neurochem. 2012 Mar;120(5):684-98
pubmed: 22035369
J Cereb Blood Flow Metab. 1993 May;13(3):521-5
pubmed: 8097519
Mol Cell Biol. 2014 Dec;34(24):4389-403
pubmed: 25266657
Nature. 2017 Jan 26;541(7638):481-487
pubmed: 28099414
Exp Mol Med. 2017 Sep 22;49(9):e379
pubmed: 28935976
Acta Neuropathol. 1999 May;97(5):447-55
pubmed: 10334481
FEBS Lett. 2005 Feb 14;579(5):1015-9
pubmed: 15710384
Sci Rep. 2014 May 14;4:4965
pubmed: 24828823
J Neurosci. 2019 Jun 12;39(24):4714-4726
pubmed: 30962276
J Cereb Blood Flow Metab. 1999 Dec;19(12):1345-53
pubmed: 10598939
Neuroscience. 2011 Aug 25;189:123-31
pubmed: 21664439
Proc Natl Acad Sci U S A. 2011 May 10;108(19):E99-107
pubmed: 21518886
Oncotarget. 2015 Jun 20;6(17):15297-310
pubmed: 25915428
Front Hum Neurosci. 2014 Jun 27;8:381
pubmed: 25018717
J Vis Exp. 2015 Apr 29;(98):e52701
pubmed: 25993447
Neuron. 2005 Mar 3;45(5):765-79
pubmed: 15748851
Nat Rev Mol Cell Biol. 2012 Oct;13(10):616-30
pubmed: 22992590
J Neuroinflammation. 2010 Oct 11;7:62
pubmed: 20937129
J Biol Chem. 2006 Sep 22;281(38):28450-9
pubmed: 16861740
J Neurosci. 2013 Mar 20;33(12):5138-51
pubmed: 23516280
Brain Res Mol Brain Res. 1996 Aug;40(1):1-14
pubmed: 8840007
J Biol Chem. 2013 Mar 22;288(12):8737-49
pubmed: 23362281
Cell. 2010 Jul 9;142(1):144-57
pubmed: 20603020
Ann Neurol. 1985 May;17(5):497-504
pubmed: 4004172
Stroke. 1993 Apr;24(4):558-62
pubmed: 8465363
Wiley Interdiscip Rev Dev Biol. 2013 Jan-Feb;2(1):47-63
pubmed: 23799630
Exp Neurol. 1995 Jan;131(1):114-23
pubmed: 7895806
Neurorehabil Neural Repair. 2012 Oct;26(8):923-31
pubmed: 22466792
Nat Rev Neurosci. 2009 Dec;10(12):861-72
pubmed: 19888284
Science. 2003 Dec 5;302(5651):1775-9
pubmed: 14657501
Cell Death Dis. 2019 May 1;10(5):360
pubmed: 31043581
J Vis Exp. 2009 Jun 12;(28):
pubmed: 19525918
J Cell Biol. 2005 Mar 28;168(7):1077-86
pubmed: 15781474
Neurosci Res. 2009 Dec;65(4):393-401
pubmed: 19744530
Am J Physiol Cell Physiol. 2003 Aug;285(2):C277-85
pubmed: 12646415
Methods Mol Biol. 2012;827:181-94
pubmed: 22144276
PLoS One. 2013 Aug 02;8(8):e71906
pubmed: 23936531
J Neurosci. 2014 Feb 26;34(9):3378-89
pubmed: 24573294
J Stroke. 2018 Jan;20(1):57-70
pubmed: 29402069
Cell Res. 2009 Jan;19(1):128-39
pubmed: 19114990
J Neurosci. 2009 Jun 3;29(22):7116-23
pubmed: 19494134
Curr Opin Neurol. 2013 Dec;26(6):609-16
pubmed: 24136129
Exp Neurol. 2017 Jan;287(Pt 3):384-394
pubmed: 26874223
J Neurosci. 2002 Dec 1;22(23):10368-76
pubmed: 12451136
J Neurosci. 2007 Oct 17;27(42):11201-13
pubmed: 17942715
Nat Neurosci. 2015 Dec;18(12):1737-45
pubmed: 26502261
Cytokine Growth Factor Rev. 2013 Feb;24(1):1-12
pubmed: 22985997
Cancer Res. 2006 Feb 1;66(3):1767-74
pubmed: 16452237
Cold Spring Harb Perspect Biol. 2016 May 02;8(5):
pubmed: 27141051
Brain. 2012 Apr;135(Pt 4):1253-67
pubmed: 22436236
Cell Transplant. 2017 Mar 13;26(3):381-394
pubmed: 27983926
J Biol Chem. 1998 Apr 3;273(14):8522-7
pubmed: 9525967
Mol Cell. 2003 Oct;12(4):817-28
pubmed: 14580334
Nat Rev Drug Discov. 2012 Oct;11(10):790-811
pubmed: 23000686
Neuron. 2011 Jan 27;69(2):231-43
pubmed: 21262463
J Neurosci Methods. 2000 Jul 31;100(1-2):25-32
pubmed: 11040363
Cell Rep. 2013 May 30;3(5):1592-606
pubmed: 23665221

Auteurs

Julia Kaiser (J)

Brain Research Institute, University of Zurich, CH-8057 Zurich, Switzerland juk4004@med.cornell.edu.
Department of Health Sciences and Technology, ETH Zurich, CH-8057 Zurich, Switzerland.
ORCID: 0000-0001-5142-6050

Martina Maibach (M)

Brain Research Institute, University of Zurich, CH-8057 Zurich, Switzerland.
Department of Health Sciences and Technology, ETH Zurich, CH-8057 Zurich, Switzerland.

Ester Piovesana (E)

Brain Research Institute, University of Zurich, CH-8057 Zurich, Switzerland.
Department of Health Sciences and Technology, ETH Zurich, CH-8057 Zurich, Switzerland.

Iris Salpeter (I)

Brain Research Institute, University of Zurich, CH-8057 Zurich, Switzerland.
Department of Health Sciences and Technology, ETH Zurich, CH-8057 Zurich, Switzerland.

Nora Escher (N)

Brain Research Institute, University of Zurich, CH-8057 Zurich, Switzerland.
Department of Health Sciences and Technology, ETH Zurich, CH-8057 Zurich, Switzerland.

Yannick Ormen (Y)

Brain Research Institute, University of Zurich, CH-8057 Zurich, Switzerland.
Department of Health Sciences and Technology, ETH Zurich, CH-8057 Zurich, Switzerland.

Martin E Schwab (ME)

Brain Research Institute, University of Zurich, CH-8057 Zurich, Switzerland.
Department of Health Sciences and Technology, ETH Zurich, CH-8057 Zurich, Switzerland.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines adaptatrices de la transduction du signal › TGFβ1 Induces Axonal Outgrowth via...
questionsmedicales.fr › Eucaryotes › Animaux › TGFβ1 Induces Axonal Outgrowth via...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Cyclic Nucleotide-Regulated Protein Kinases › Cyclic AMP-Dependent Protein Kinases › TGFβ1 Induces Axonal Outgrowth via...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › TGFβ1 Induces Axonal Outgrowth via...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › TGFβ1 Induces Axonal Outgrowth via...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Neurogenèse › Excroissance neuronale › TGFβ1 Induces Axonal Outgrowth via...
questionsmedicales.fr › Métabolisme › Phosphorylation › TGFβ1 Induces Axonal Outgrowth via...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur facteur croissance › Récepteurs TGF-bêta › Récepteur de type I du facteur de croissance transformant bêta › TGFβ1 Induces Axonal Outgrowth via...
questionsmedicales.fr › Phénomènes biologiques › Récupération fonctionnelle › TGFβ1 Induces Axonal Outgrowth via...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › TGFβ1 Induces Axonal Outgrowth via...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Protéines de la superfamille du TGF bêta › Facteur de croissance transformant bêta › Facteur de croissance transformant bêta-1 › TGFβ1 Induces Axonal Outgrowth via...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Ligases › Ubiquitin-protein ligase complexes › Ubiquitin-protein ligases › TGFβ1 Induces Axonal Outgrowth via...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines G › Protéines G monomériques › Protéines G rho › Protéine G RhoA › TGFβ1 Induces Axonal Outgrowth via...