Developmental neuroplasticity of the white matter connectome in children with perinatal stroke.
Journal
Neurology
ISSN: 1526-632X
Titre abrégé: Neurology
Pays: United States
ID NLM: 0401060
Informations de publication
Date de publication:
03 11 2020
03 11 2020
Historique:
received:
06
12
2019
accepted:
03
06
2020
pubmed:
6
9
2020
medline:
15
12
2020
entrez:
5
9
2020
Statut:
ppublish
Résumé
To employ diffusion imaging connectome methods to explore network development in the contralesional hemisphere of children with perinatal stroke and its relationship to clinical function. We hypothesized alterations in global efficiency of the intact hemisphere would correlate with clinical disability. Children with unilateral perinatal arterial (n = 26) or venous (n = 27) stroke and typically developing controls (n = 32) underwent 3T diffusion and T1 anatomical MRI and completed established motor assessments. A validated atlas coregistered to whole-brain tractography for each individual was used to estimate connectivity between 47 regions. Graph theory metrics (assortativity, hierarchical coefficient of regression, global and local efficiency, and small worldness) were calculated for the left hemisphere of controls and the intact contralesioned hemisphere of both stroke groups. Validated clinical motor assessments were then correlated with connectivity outcomes. Global efficiency was higher in arterial strokes compared to venous strokes ( The structural connectome of the contralesional hemisphere is altered after perinatal stroke and correlates with clinical function. Connectomics represents a powerful tool to understand whole brain developmental plasticity in children with disease-specific cerebral palsy.
Identifiants
pubmed: 32887781
pii: WNL.0000000000010669
doi: 10.1212/WNL.0000000000010669
pmc: PMC7682831
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2476-e2486Subventions
Organisme : CIHR
Pays : Canada
Informations de copyright
© 2020 American Academy of Neurology.
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