The transcription factor E2A activates multiple enhancers that drive

Animals Animals, Genetically Modified B-Lymphocytes / immunology Basic Helix-Loop-Helix Transcription Factors / genetics DNA-Binding Proteins / genetics Female Homeodomain Proteins / genetics Male Mice T-Lymphocytes / immunology

Journal

Science immunology
ISSN: 2470-9468
Titre abrégé: Sci Immunol
Pays: United States
ID NLM: 101688624

Informations de publication

Date de publication:
04 09 2020
Historique:
received: 09 02 2020
accepted: 21 07 2020
entrez: 5 9 2020
pubmed: 6 9 2020
medline: 11 1 2022
Statut: ppublish

Résumé

Cell type-specific gene expression is driven by the interplay between lineage-specific transcription factors and cis-regulatory elements to which they bind. Adaptive immunity relies on RAG-mediated assembly of T cell receptor (

Identifiants

DOI: 10.1126/sciimmunol.abb1455 PMID: 32887843
pubmed: 32887843
pii: 5/51/eabb1455
doi: 10.1126/sciimmunol.abb1455
pii:
doi:

Substances chimiques

Basic Helix-Loop-Helix Transcription Factors 0
DNA-Binding Proteins 0
Homeodomain Proteins 0
Rag2 protein, mouse 0
Tcf3 protein, mouse 0
RAG-1 protein 128559-51-3

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

Auteurs

Kazuko Miyazaki (K)

Laboratory of Immunology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606-8507, Japan.
ORCID: 0000-0001-9754-698X

Hitomi Watanabe (H)

Laboratory of Integrative Biological Sciences, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606-8507, Japan.

Genki Yoshikawa (G)

Institute for Chemical Research, Kyoto University, Uji 611-0011, Japan.

Kenian Chen (K)

Baylor Institute for Immunology Research, Baylor Scott & White Research Institute, Dallas, TX, USA.
ORCID: 0000-0002-4083-841X

Reiko Hidaka (R)

Laboratory of Immunology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606-8507, Japan.

Yuki Aitani (Y)

Laboratory of Immunology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606-8507, Japan.

Kai Osawa (K)

Laboratory of Immunology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606-8507, Japan.

Rie Takeda (R)

Laboratory of Integrative Biological Sciences, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606-8507, Japan.

Yotaro Ochi (Y)

Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan.
ORCID: 0000-0001-8472-6164

Shizue Tani-Ichi (S)

Laboratory of Immune Regulation, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606-8507, Japan.
ORCID: 0000-0003-2388-776X

Takuya Uehata (T)

Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan.
ORCID: 0000-0003-3517-2198

Osamu Takeuchi (O)

Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan.
ORCID: 0000-0002-1260-6232

Koichi Ikuta (K)

Laboratory of Immune Regulation, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606-8507, Japan.

Seishi Ogawa (S)

Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan.
Institute for the Advanced Study of Human Biology (WPI ASHBi), Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan.
Department of Medicine, Center for Hematology and Regenerative Medicine, Karolinska Institute, Stockholm, Sweden.
ORCID: 0000-0002-7778-5374

Gen Kondoh (G)

Laboratory of Integrative Biological Sciences, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606-8507, Japan.
ORCID: 0000-0002-2564-0149

Yin C Lin (YC)

Baylor Institute for Immunology Research, Baylor Scott & White Research Institute, Dallas, TX, USA.

Hiroyuki Ogata (H)

Institute for Chemical Research, Kyoto University, Uji 611-0011, Japan.
ORCID: 0000-0001-6594-377X

Masaki Miyazaki (M)

Laboratory of Immunology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606-8507, Japan. mmiyazaki@infront.kyoto-u.ac.jp.
ORCID: 0000-0002-9543-624X

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › The transcription factor E2A activates...
questionsmedicales.fr › Stades d'organismes › Organismes génétiquement modifiés › Animal génétiquement modifié › The transcription factor E2A activates...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes B › The transcription factor E2A activates...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription à motif basique hélice-boucle-hélice › The transcription factor E2A activates...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de liaison à l'ADN › The transcription factor E2A activates...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de liaison à l'ADN › Protéines à homéodomaine › The transcription factor E2A activates...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › The transcription factor E2A activates...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › The transcription factor E2A activates...