Association between the microbiomes of tonsil and saliva samples isolated from pediatric patients subjected to tonsillectomy for the treatment of tonsillar hyperplasia.
Journal
Experimental & molecular medicine
ISSN: 2092-6413
Titre abrégé: Exp Mol Med
Pays: United States
ID NLM: 9607880
Informations de publication
Date de publication:
09 2020
09 2020
Historique:
received:
10
04
2020
accepted:
07
07
2020
revised:
17
06
2020
pubmed:
6
9
2020
medline:
28
9
2021
entrez:
5
9
2020
Statut:
ppublish
Résumé
Oral microbes have the capacity to spread throughout the gastrointestinal system and are strongly associated with multiple diseases. Given that tonsils are located between the oral cavity and the laryngopharynx at the gateway of the alimentary and respiratory tracts, tonsillar tissue may also be affected by microbiota from both the oral cavity (saliva) and the alimentary tract. Here, we analyzed the distribution and association of the microbial communities in the saliva and tonsils of Korean children subjected to tonsillectomy because of tonsil hyperplasia (n = 29). The microbiome profiles of saliva and tonsils were established via 16S rRNA gene sequencing. Based on the alpha diversity indices, the microbial communities of the two groups showed high similarities. According to Spearman's ranking correlation analysis, the distribution of Treponema, the causative bacterium of periodontitis, in saliva and tonsils was found to have a significant positive correlation. Two representative microbes, Prevotella in saliva and Alloprevotella in tonsils, were negatively correlated, while Treponema 2 showed a strong positive correlation between saliva and tonsils. Taken together, strong similarities in the microbial communities of the tonsils and saliva are evident in terms of diversity and composition. The saliva microbiome is expected to significantly affect the tonsil microbiome. Furthermore, we suggest that our study creates an opportunity for tonsillar microbiome research to facilitate the development of novel microbiome-based therapeutic strategies.
Identifiants
pubmed: 32887934
doi: 10.1038/s12276-020-00487-6
pii: 10.1038/s12276-020-00487-6
pmc: PMC8080726
doi:
Substances chimiques
Biomarkers
0
RNA, Ribosomal, 16S
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1564-1573Subventions
Organisme : National Research Foundation of Korea (NRF)
ID : 2016M3A9B4919639
Organisme : National Research Foundation of Korea (NRF)
ID : 2017R1A2B4002611
Organisme : National Research Foundation of Korea (NRF)
ID : 2019M3A9H1032376
Organisme : National Research Foundation of Korea (NRF)
ID : 2016R1D1A1B04932112
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