Optical coherence tomography angiography in diabetes: focus on microaneurysms.
Journal
Eye (London, England)
ISSN: 1476-5454
Titre abrégé: Eye (Lond)
Pays: England
ID NLM: 8703986
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
03
08
2020
accepted:
25
08
2020
revised:
18
08
2020
pubmed:
6
9
2020
medline:
22
6
2021
entrez:
5
9
2020
Statut:
ppublish
Résumé
The introduction of optical coherence tomography angiography (OCTA) has remarkably expanded our knowledge of the ocular vascular alterations occurring in diabetes. In this article, a review of the prominent OCTA findings in diabetes is followed by a description of salient histological and anatomical features of microaneurysms, essential for the proper interpretation of in vivo imaging of these retinal vascular abnormalities. The recent employment of a three-dimensional (3D) visualization in OCTA imaging is also discussed. The latter imaging technique has granted a detailed characterization of microaneurysms in vivo. 摘要: 光学相干断层扫描血管成像(optical coherence tomography angiography, OCTA) 在临床的广泛应用加深了我们对糖尿病眼部血管改变的认识。本文首先对OCTA针对糖尿病的重要发现进行了回顾, 随后描述了微血管瘤显著的组织学及解剖学特征, 这对合理解释视网膜血管异常的体内成像至关重要。本文进一步讨论了OCTA中应用三维 (three-dimensional, 3D) 可视化成像的最新进展, 这种新的影像成像技术可实现描述活体微血管瘤的细节特征。.
Autres résumés
Type: Publisher
(chi)
摘要: 光学相干断层扫描血管成像(optical coherence tomography angiography, OCTA) 在临床的广泛应用加深了我们对糖尿病眼部血管改变的认识。本文首先对OCTA针对糖尿病的重要发现进行了回顾, 随后描述了微血管瘤显著的组织学及解剖学特征, 这对合理解释视网膜血管异常的体内成像至关重要。本文进一步讨论了OCTA中应用三维 (three-dimensional, 3D) 可视化成像的最新进展, 这种新的影像成像技术可实现描述活体微血管瘤的细节特征。.
Identifiants
pubmed: 32887935
doi: 10.1038/s41433-020-01173-7
pii: 10.1038/s41433-020-01173-7
pmc: PMC7852676
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
142-148Références
De Benedetto U, Querques G, Lattanzio R, Borrelli E, Triolo G, Maestranzi G, et al. Macular dysfunction is common in both type 1 and type 2 diabetic patients without macular edema. Retina. 2014;34:2171–7.
doi: 10.1097/IAE.0000000000000205
Carpineto P, Toto L, Aloia R, Ciciarelli V, Borrelli E, Vitacolonna E, et al. Neuroretinal alterations in the early stages of diabetic retinopathy in patients with type 2 diabetes mellitus. Eye. 2016;30:673–9.
doi: 10.1038/eye.2016.13
Spaide RRF, Fujimoto JG, Waheed NK, Sadda SR, Staurenghi G. Optical coherence tomography angiography. Prog Retin Eye Res. 2017;64:1–55.
doi: 10.1016/j.preteyeres.2017.11.003
Borrelli E, Sarraf D, Freund KB, Sadda SR. OCT angiography and evaluation of the choroid and choroidal vascular disorders. Prog Retin Eye Res. 2018;67:30–55.
Borrelli E, Sadda SR, Uji A, Querques G. Pearls and pitfalls of optical coherence tomography angiography imaging: a review. Ophthalmol Ther. 2019;8:215–26.
Borrelli E, Sadda SR, Uji A, Querques G. OCT angiography: guidelines for analysis and interpretation. In: OCT and Imaging in Central Nervous System Diseases. Springer; 2020. p. 41–54
Savastano MC, Lumbroso B, Rispoli M. In vivo characterization of retinal vascularization morphology using optical coherence tomography angiography. Retina. 2015;35:2196–203.
Garrity ST, Paques M, Gaudric A, Freund KB, Sarraf D. Considerations in the understanding of venous outflow in the retinal capillary plexus. Retina. 2017;1809–12.
Campbell JP, Zhang M, Hwang TS, Bailey ST, Wilson DJ, Jia Y, et al. Detailed vascular anatomy of the human retina by projection-resolved optical coherence tomography angiography. Sci Rep. 2017;7:42201.
doi: 10.1038/srep42201
Nesper PL, Fawzi AA. Human parafoveal capillary vascular anatomy and connectivity revealed by optical coherence tomography angiography. Investig Ophthalmol Vis Sci. 2018;59:3858–67.
Vujosevic S, Muraca A, Alkabes M, Villani E, Cavarzeran F, Rossetti L, et al. Early microvascular and neural changes in patients with type 1 and type 2 diabetes mellitus without clinical signs of diabetic retinopathy. Retina. 2019;39:435–45.
De Carlo TE, Chin AT, Bonini Filho MA, Adhi M, Branchini L, Salz DA, et al. Detection of microvascular changes in eyes of patients with diabetes but not clinical diabetic retinopathy using optical coherence tomography angiography. Retina. 2015;35:2364–70.
Carnevali A, Sacconi R, Corbelli E, Tomasso L, Querques L, Zerbini G, et al. Optical coherence tomography angiography analysis of retinal vascular plexuses and choriocapillaris in patients with type 1 diabetes without diabetic retinopathy. Acta Diabetol. 2017;54:695–702.
Samara WA, Shahlaee A, Adam MK, Khan MA, Chiang A, Maguire JI, et al. Quantification of diabetic macular ischemia using optical coherence tomography angiography and its relationship with visual acuity. Ophthalmology. 2017;124:235–44.
Alagorie AR, Nittala MG, Velaga S, Zhou B, Rusakevich AM, Wykoff CC, et al. Association of intravitreal aflibercept with optical coherence tomography angiography vessel density in patients with proliferative diabetic retinopathy. JAMA Ophthalmol. 2020;138:851–7.
doi: 10.1001/jamaophthalmol.2020.2130
Borrelli E, Sacconi R, Querques G, Re Couturier, et al. Widefield OCT-angiography and fluorescein angiography assessments of nonperfusion in diabetic retinopathy and edema treated with anti–vascular endothelial growth factor. Ophthalmology. 2019;126:1685–94.
doi: 10.1016/j.ophtha.2019.06.022
Greig EC, Brigell M, Cao F, Levine ES, Peters K, Moult EM, et al. Macular and peripapillary OCTA metrics predict progression in diabetic retinopathy: a sub-analysis of TIME-2b Study Data. Am J Ophthalmol. 2020. https://doi.org/10.1016/j.ajo.2020.06.009 .
Giuffrè C, Carnevali A, Cicinelli MV, Querques L, Querques G, Bandello F. Optical coherence tomography angiography of venous loops in diabetic retinopathy. Ophthalmic Surg Lasers Imaging Retin. 2017;48:518–20.
Elbendary AM, Abouelkheir HY. Bimodal imaging of proliferative diabetic retinopathy vascular features using swept source optical coherence tomography angiography. Int J Ophthalmol. 2018;11:1528.
Ishibazawa A, Nagaoka T, Takahashi A, Omae T, Tani T, Sogawa K, et al. Optical coherence tomography angiography in diabetic retinopathy: a prospective pilot study. Am J Ophthalmol. 2015;160:35–44.
doi: 10.1016/j.ajo.2015.04.021
Lee CS, Lee AY, Sim DA, Keane PA, Mehta H, Zarranz-Ventura J, et al. Reevaluating the definition of intraretinal microvascular abnormalities and neovascularization elsewhere in diabetic retinopathy using optical coherence tomography and fluorescein angiography. Am J Ophthalmol. 2015;159:101–10.
Shimouchi A, Ishibazawa A, Ishiko S, Omae T, Ro-Mase T, Yanagi Y, et al. A proposed classification of intraretinal microvascular abnormalities in diabetic retinopathy following panretinal photocoagulation. Investig Ophthalmol Vis Sci. 2020;61:34.
Ishibazawa A, Nagaoka T, Yokota H, Takahashi A, Omae T, Song YS, et al. Characteristics of retinal neovascularization in proliferative diabetic retinopathy imaged by optical coherence tomography angiography. Investig Ophthalmol Vis Sci. 2016;57:6247–55.
doi: 10.1167/iovs.16-20210
Sawada O, Ichiyama Y, Obata S, Ito Y, Kakinoki M, Sawada T, et al. Comparison between wide-angle OCT angiography and ultra-wide field fluorescein angiography for detecting non-perfusion areas and retinal neovascularization in eyes with diabetic retinopathy. Graefe’s Arch Clin Exp Ophthalmol. 2018;256:1275–80.
Cui Y, Zhu Y, Wang JC, Lu Y, Zeng R, Katz R, et al. Comparison of widefield swept-source optical coherence tomography angiography with ultra-widefield colour fundus photography and fluorescein angiography for detection of lesions in diabetic retinopathy. Br J Ophthalmol. 2020. https://doi.org/10.1136/bjophthalmol-2020-316245
You QS, Guo Y, Wang J, Wei X, Camino A, Zang P, et al. Detection of clinically unsuspected retinal neovascularization with wide-field optical coherence tomography angiography. Retina. 2020;40:891–7.
doi: 10.1097/IAE.0000000000002487
Borrelli E, Viggiano P, Evangelista F, Toto L, Mastropasqua R. Eyelashes artifact in ultra-widefield optical coherence tomography angiography. Ophthalmic Surg Lasers Imaging Retin. 2019;50:740–3.
Cui Y, Zhu Y, Wang JC, Lu Y, Zeng R, Katz R, et al. Imaging artifacts and segmentation errors with wide-field swept-source optical coherence tomography angiography in diabetic retinopathy. Transl Vis Sci Technol. 2019;8:18.
Battista M, Borrelli E, Sacconi R, Bandello F, Querques G. Optical coherence tomography angiography in diabetes: a review. Eur J Ophthalmol. 2020;30:411–6.
Spaide RF. Volume rendering of optical coherence tomography angiography reveals extensive retinal vascular contributions to neovascularization in ocular toxoplasmosis. Retina. 2015;35:2421–2.
Spaide RF, Suzuki M, Yannuzzi LA, Matet A, Behar-Cohen F. Volume-rendered angiographic and structural optical coherence tomography angiography of macular telangiectasia type 2. Retina. 2017;37:424–35.
Borrelli E, Sacconi R, Brambati M, Bandello F, Querques G. In vivo rotational three-dimensional OCTA analysis of microaneurysms in the human diabetic retina. Sci Rep. 2019;9:1–8.
Borrelli E, Sacconi R, Klose G, de Sisternes L, Bandello F, Querques G. Rotational three-dimensional OCTA: a notable new imaging tool to characterize type 3 macular neovascularization. Sci Rep. 2019;9:1–8.
Borrelli E, Sacconi R, Querques L, Battista M, Bandello F, Querques G. Quantification of diabetic macular ischemia using novel three-dimensional optical coherence tomography angiography metrics. J Biophoton. 2020:e202000152. https://doi.org/10.1002/jbio.202000152 .
Ghasemi Falavarjani K, Habibi A, Anvari P, Ghasemizadeh S, Ashraf Khorasani M, Shenazandi H, et al. Effect of segmentation error correction on optical coherence tomography angiography measurements in healthy subjects and diabetic macular oedema. Br J Ophthalmol. 2020;104:162–6.
Czakó C, Sándor G, Ecsedy M, Récsán Z, Horváth H, Szepessy Z, et al. Intrasession and between-visit variability of retinal vessel density values measured with OCT angiography in diabetic patients. Sci Rep. 2018;8:1–8.
You Q, Freeman WR, Weinreb RN, Zangwill L, Manalastas PIC, Saunders LJ, et al. Reproducibility of vessel density measurement with optical coherence tomography angiography in eyes with and without retinopathy. Retina. 2017;37:1475.
Nagaoka T, Kitaya N, Sugawara R, Yokota H, Mori F, Hikichi T, et al. Alteration of choroidal circulation in the foveal region in patients with type 2 diabetes. Br J Ophthalmol. 2004;88:1060–3.
doi: 10.1136/bjo.2003.035345
Choi W, Waheed NK, Moult EM, Adhi M, Lee B, De Carlo T, et al. Ultrahigh speed swept source optical coherence tomography angiography of retinal and choriocapillaris alterations in diabetic patients with and without retinopathy. Retina. 2017;37:11–21.
doi: 10.1097/IAE.0000000000001250
Borrelli E, Palmieri M, Viggiano P, Ferro G, Mastropasqua R. Photoreceptor damage in diabetic choroidopathy. Retina. 2019;40:1062–9.
Dodo Y, Suzuma K, Ishihara K, Yoshitake S, Fujimoto M, Yoshitake T, et al. Clinical relevance of reduced decorrelation signals in the diabetic inner choroid on optical coherence tomography angiography. Sci Rep. 2017;7:1–11.
Wiley HE, Ferris FL. Nonproliferative diabetic retinopathy and diabetic macular edema. 5th edn. In: Retina; 2012. Vol. 2, p. 940–68. https://doi.org/10.1016/B978-1-4557-0737-9.00047-3 .
Ashton N. Studies of the retinal capillaries in relation to diabetic and other retinopathies. Br J Ophthalmol. 1963;47:521.
Feman SS. The natural history of the first clinically visible features of diabetic retinopathy. Trans Am Ophthalmol Soc. 1994;92:745.
Fryczkowski AW, Chambers RB, Craig EJ, Walker J, Davidorf FH. Scanning electron microscopic study of microaneurysms in the diabetic retina. Ann Ophthalmol. 1991;23:130–6.
Moore J, Bagley S, Ireland G, McLeod D, Boulton ME. Three dimensional analysis of microaneurysms in the human diabetic retina. J Anat. 1999;194:89–100.
Hasegawa N, Nozaki M, Takase N, Yoshida M, Ogura Y. New insights into microaneurysms in the deep capillary plexus detected by optical coherence tomography angiography in diabetic macular edema. Investig Ophthalmol Vis Sci. 2016:57:348–55.
Parravano M, De Geronimo D, Scarinci F, Querques L, Virgili G, Simonett JM, et al. Diabetic microaneurysms internal reflectivity on spectral-domain optical coherence tomography and optical coherence tomography angiography detection. Am J Ophthalmol 2017;179:90–6.
doi: 10.1016/j.ajo.2017.04.021
Parravano M, De Geronimo D, Scarinci F, Virgili G, Querques L, Varano M, et al. Progression of diabetic microaneurysms according to the internal reflectivity on structural optical coherence tomography and visibility on optical coherence tomography angiography. Am J Ophthalmol. 2019;198:8–16.
doi: 10.1016/j.ajo.2018.09.031
Querques G, Bandello F, Souied EH. Abnormal deep retinal capillary networking and microaneurysms in the outer nuclear layer of diabetic eyes. Ophthalmology. 2014;121:803–4.
Parrulli S, Corvi F, Cozzi M, Monteduro D, Zicarelli F, Staurenghi G. Microaneurysms visualisation using five different optical coherence tomography angiography devices compared to fluorescein angiography. Br J Ophthalmol. 2020. https://doi.org/10.1136/bjophthalmol-2020-316817 .
Kaizu Y, Nakao S, Wada I, Arima M, Yamaguchi M, Ishikawa K, et al. Microaneurysm imaging using multiple en face OCT angiography image averaging: morphology and visualization. Ophthalmol Retin. 2020;4:175–86.
Schneider CA, Rasband WS, Eliceiri KW. NIH Image to ImageJ: 25 years of image analysis. Nat Methods. 2012;9:671–5.
Wang H, Chhablani J, Freeman WR, Chan CK, Kozak I, Bartsch DU, et al. Characterization of diabetic microaneurysms by simultaneous fluorescein angiography and spectral-domain optical coherence tomography. Am. J. Ophthalmol. 2012;153:861–7.
Karst SG, Salas M, Hafner J, Scholda C, Vogl W-D, Drexler W, et al. Three-dimensional analysis of retinal microaneurysms with adaptive optics optical coherence tomography. Retina. 2019;39:465–72.