Combined effects of maternal exposure to fungicides on behavioral development in F
behavioral development
enilconazole
fungicide
imazalil
maternal exposure
mice
movement activity
reproductive toxicity
spontaneous behavior
thiabendazole
Journal
Birth defects research
ISSN: 2472-1727
Titre abrégé: Birth Defects Res
Pays: United States
ID NLM: 101701004
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
21
05
2020
revised:
20
07
2020
accepted:
17
08
2020
pubmed:
6
9
2020
medline:
19
8
2021
entrez:
5
9
2020
Statut:
ppublish
Résumé
Few published studies are reported for the neurobehavioral toxicity of combined exposure to fungicides in mammals. This study was aimed to re-evaluate the reproductive and neurobehavioral effects of maternal exposure to combined imazalil (IMZ) and thiabendazole (TBZ) with fixed-dose of TBZ in mice. IMZ/TBZ were given in the diet to provide levels of 0%/0% (control), 0.0015%/0.018% (IMZ/TBZ), 0.006%/0.018% and 0.024%/0.018% during the gestation and lactation periods. Selected reproductive and neurobehavioral parameters were measured in the F No adverse effect of IMZ/TBZ was observed in litter size, litter weight, or sex ratio at birth. Concerning behavioral developmental parameters, the cliff avoidance on PND 7 of male offspring was restrained significantly in the treatment groups in a dose-related manner. Exploratory behavior examination indicated that the average time of rearing significantly lengthened in the high-dose group of male offspring. After weaning, the average time of rearing in exploratory behavior lengthened in a significant dose-related trend in adult females of the F The results from two combined exposure studies of IMZ/TBZ suggest that TBZ concentrations have caused major effects on exploratory and spontaneous behavior.
Sections du résumé
BACKGROUND
Few published studies are reported for the neurobehavioral toxicity of combined exposure to fungicides in mammals. This study was aimed to re-evaluate the reproductive and neurobehavioral effects of maternal exposure to combined imazalil (IMZ) and thiabendazole (TBZ) with fixed-dose of TBZ in mice.
METHODS
IMZ/TBZ were given in the diet to provide levels of 0%/0% (control), 0.0015%/0.018% (IMZ/TBZ), 0.006%/0.018% and 0.024%/0.018% during the gestation and lactation periods. Selected reproductive and neurobehavioral parameters were measured in the F
RESULTS
No adverse effect of IMZ/TBZ was observed in litter size, litter weight, or sex ratio at birth. Concerning behavioral developmental parameters, the cliff avoidance on PND 7 of male offspring was restrained significantly in the treatment groups in a dose-related manner. Exploratory behavior examination indicated that the average time of rearing significantly lengthened in the high-dose group of male offspring. After weaning, the average time of rearing in exploratory behavior lengthened in a significant dose-related trend in adult females of the F
CONCLUSIONS
The results from two combined exposure studies of IMZ/TBZ suggest that TBZ concentrations have caused major effects on exploratory and spontaneous behavior.
Substances chimiques
Fungicides, Industrial
0
Thiabendazole
N1Q45E87DT
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1809-1824Informations de copyright
© 2020 Wiley Periodicals LLC.
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