Isolation and structure characterization of cytotoxic alkaloids from Micromelum integerrimum.

Alkaloids Antineoplastic Agents Cell Line, Tumor Humans Molecular Structure Plant Leaves Rutaceae
Aldimine Atropisomers Carbazole Cytotoxicity Heterodimers Micromelum integerrimum (Buch.-ham.) roem. Pyrrolone Rutaceae

Journal

Phytochemistry
ISSN: 1873-3700
Titre abrégé: Phytochemistry
Pays: England
ID NLM: 0151434

Informations de publication

Date de publication:
Oct 2020
Historique:
received: 06 04 2020
revised: 14 07 2020
accepted: 15 07 2020
entrez: 5 9 2020
pubmed: 6 9 2020
medline: 9 9 2020
Statut: ppublish

Résumé

Ten undescribed alkaloids, named integerrines A-J, including one racemic heterodimer of carbazole and indole, two racemic, two scalemic, and one enantiomerically enriched biscarbazoles, two aldoximes, and one racemic pyrrolone, were isolated from the dried leaves and stems of Micromelum integerrimum. The racemic or scalemic compounds were resolved using chiral-phase HPLC and their configurations were determined by comparison of experimental and calculated ECD data. Four compounds exhibited moderate to weak cytotoxicities against HepG2, HTC-116, HeLa, and PANC-1 cell lines, with IC

Identifiants

DOI: 10.1016/j.phytochem.2020.112463 PMID: 32888669
pubmed: 32888669
pii: S0031-9422(20)30308-3
doi: 10.1016/j.phytochem.2020.112463
pii:
doi:

Substances chimiques

Alkaloids 0
Antineoplastic Agents 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

112463

Informations de copyright

Copyright © 2020 Elsevier Ltd. All rights reserved.

Auteurs

Nan-Kai Cao (NK)

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, People's Republic of China.

Yue-Mei Chen (YM)

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, People's Republic of China.

Si-Si Zhu (SS)

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, People's Republic of China.

Ke-Wu Zeng (KW)

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, People's Republic of China.

Ming-Bo Zhao (MB)

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, People's Republic of China.

Jun Li (J)

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, People's Republic of China.

Peng-Fei Tu (PF)

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, People's Republic of China.

Yong Jiang (Y)

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, People's Republic of China. Electronic address: yongjiang@bjmu.edu.cn.

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Classifications MeSH

questionsmedicales.fr › Composés hétérocycliques › Alcaloïdes › Isolation and structure characterization of...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Isolation and structure characterization of...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Isolation and structure characterization of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Isolation and structure characterization of...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Isolation and structure characterization of...
questionsmedicales.fr › Structures de plante › Parties aériennes de plante › Feuilles de plante › Isolation and structure characterization of...
questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Rutaceae › Isolation and structure characterization of...