Stability of live attenuated classical swine fever cell culture vaccine virus in liquid form for developing an oral vaccine.
Administration, Oral
Animals
Antibodies, Viral
/ immunology
Cell Culture Techniques
/ methods
Cell Line
Classical Swine Fever
/ immunology
Classical Swine Fever Virus
/ immunology
Drug Stability
Fluorescent Antibody Technique, Indirect
/ methods
Freeze Drying
/ methods
Swine
Temperature
Vaccination
/ methods
Vaccines, Attenuated
/ administration & dosage
Viral Load
/ immunology
Viral Vaccines
/ administration & dosage
Classical swine fever vaccine
Fluorescent antibody technique
Lactalbumin hydrolysate
Oral
Stability
Trehalose
Journal
Biologicals : journal of the International Association of Biological Standardization
ISSN: 1095-8320
Titre abrégé: Biologicals
Pays: England
ID NLM: 9004494
Informations de publication
Date de publication:
Nov 2020
Nov 2020
Historique:
received:
02
04
2020
revised:
18
05
2020
accepted:
20
07
2020
pubmed:
6
9
2020
medline:
31
8
2021
entrez:
5
9
2020
Statut:
ppublish
Résumé
Classical swine fever (CSF) is an important viral disease of pigs and controlled by vaccination. Unorganised backyard and wild pigs are difficult to vaccinate by needle vaccination. Here we formulated liquid vaccines using an Indian CSF cell culture vaccine virus and four stabilisers and evaluated their stability at 4 °C, 25 °C and 37 °C up to 24 h for use as oral vaccine. The stabilisers were Lactalbumin hydrolysate-Trehalose, Lactalbumin hydrolysate-Trehalose-Gelatin, Lactalbumin hydrolysate-Lactose-Sucrose and Lactalbumin hydrolysate-Sucrose. The liquid vaccines, with or without stabilisers, were stable at 4 °C up to 24 h, whereas, a drop of one log
Identifiants
pubmed: 32888775
pii: S1045-1056(20)30084-1
doi: 10.1016/j.biologicals.2020.07.004
pii:
doi:
Substances chimiques
Antibodies, Viral
0
Vaccines, Attenuated
0
Viral Vaccines
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
108-111Informations de copyright
Copyright © 2020 International Alliance for Biological Standardization. Published by Elsevier Ltd. All rights reserved.