SARS-CoV-2 respiratory viral loads and association with clinical and biological features.
Adult
Aged
Aged, 80 and over
Anosmia
/ pathology
C-Reactive Protein
/ analysis
COVID-19
/ diagnosis
COVID-19 Testing
/ methods
Dyspnea
/ pathology
Female
Fibrinogen
/ analysis
France
/ epidemiology
Humans
L-Lactate Dehydrogenase
/ blood
Male
Middle Aged
Nasopharynx
/ virology
Prealbumin
/ analysis
RNA, Viral
/ analysis
SARS-CoV-2
Treatment Outcome
Viral Load
/ methods
Virus Shedding
Young Adult
COVID-19
SARS-CoV-2
inflammation
viral loads
Journal
Journal of medical virology
ISSN: 1096-9071
Titre abrégé: J Med Virol
Pays: United States
ID NLM: 7705876
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
received:
08
08
2020
revised:
21
08
2020
accepted:
24
08
2020
pubmed:
6
9
2020
medline:
11
3
2021
entrez:
5
9
2020
Statut:
ppublish
Résumé
To determine the distribution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) respiratory viral loads (VL) during the acute phase of infection and their correlation with clinical presentation and inflammation-related biomarkers. Nasopharyngeal swabs from 453 adult SARS-CoV-2-infected patients from the Department of Infectious Diseases, Besançon, France, were collected at the time of admission or consultation for reverse transcriptase polymerase chain reaction (RT-PCR) analysis. Clinical information and concentrations of biological parameters (C-reactive protein [CRP], fibrinogen, lactate dehydrogenase [LDH], prealbumin) were noticed. Mean respiratory VL homogeneously decreased from 7.2 log
Substances chimiques
Prealbumin
0
RNA, Viral
0
Fibrinogen
9001-32-5
C-Reactive Protein
9007-41-4
L-Lactate Dehydrogenase
EC 1.1.1.27
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1761-1765Informations de copyright
© 2020 Wiley Periodicals LLC.
Références
Zhu N, Zhang D, Wang W, et al. A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med. 2020;382(8):727-733. https://doi.org/10.1056/NEJMoa2001017
He X, Lau EHY, Wu P, et al. Temporal dynamics in viral shedding and transmissibility of COVID-19. Nat Med. 2020;26(5):672-675. https://doi.org/10.1038/s41591-020-0869-5
Lescure FX, Bouadma L, Nguyen D, et al. Clinical and virological data of the first cases of COVID-19 in Europe: a case series. Lancet Infect Dis. 2020;20:697-706. https://doi.org/10.1016/S1473-3099(20)30200-0
To KK-W, Tsang OT-Y, Leung W-S, et al. Temporal profiles of viral load in posterior oropharyngeal saliva samples and serum antibody responses during infection by SARS-CoV-2: an observational cohort study. Lancet Infect Dis. 2020;20(5):565-574. https://doi.org/10.1016/S1473-3099(20)30196-1
Zou L, Ruan F, Huang M, et al. SARS-CoV-2 viral load in upper respiratory specimens of infected patients. N Engl J Med. 2020;382(12):1177-1179. https://doi.org/10.1056/NEJMc2001737
Wölfel R, Corman VM, Guggemos W, et al. Virological assessment of hospitalized patients with COVID-2019. Nature. 2020;581:465-469. https://doi.org/10.1038/s41586-020-2196-x
Corman VM, Landt O, Kaiser M, et al. Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR. Euro Surveill. 2020;25(3):2000045. https://doi.org/10.2807/1560-7917.ES.2020.25.3.2000045
Bernard Stoecklin S, Rolland P, Silue Y, et al. First cases of coronavirus disease 2019 (COVID-19) in France: surveillance, investigations and control measures, January 2020. Euro Surveill. 2020;25(6):2000094. https://doi.org/10.2807/1560-7917.ES.2020.25.6.2000094
Chen G, Wu D, Guo W, et al. Clinical and immunological features of severe and moderate coronavirus disease 2019. J Clin Invest. 2020;130(5):2620-2629. https://doi.org/10.1172/JCI137244
Qin C, Zhou L, Hu Z, et al. Dysregulation of immune response in patients with COVID-19 in Wuhan, China. Clin Infect Dis. 2020;71:762-768. https://doi.org/10.1093/cid/ciaa248
Tay MZ, Poh CM, Rénia L, MacAry PA, Ng LFP. The trinity of COVID-19: immunity, inflammation, and intervention. Nat Rev Immunol. 2020;20:363-374. https://doi.org/10.1038/s41577-020-0311-8
Zheng S, Fan J, Yu F, et al. Viral load dynamics and disease severity in patients infected with SARS-CoV-2 in Zhejiang province, China, January-March 2020: retrospective cohort study. BMJ. 2020;369:m1443. https://doi.org/10.1136/bmj.m1443
Haran JP, Beaudoin FL, Suner S, Lu S. C-reactive protein as predictor of bacterial infection among patients with an influenza-like illness. Am J Emerg Med. 2013;31(1):137-144. https://doi.org/10.1016/j.ajem.2012.06.026
Chen X, Zhao B, Qu Y, et al. Detectable serum SARS-CoV-2 viral load (RNAaemia) is closely correlated with drastically elevated interleukin 6 (IL-6) level in critically ill COVID-19 patients. Clin Infect Dis. 2020. https://doi.org/10.1093/cid/ciaa449