No Observed Effect Level (NOEL) for Systemic Inflammation by Copper and Zinc in Welding Fumes.
Journal
Journal of occupational and environmental medicine
ISSN: 1536-5948
Titre abrégé: J Occup Environ Med
Pays: United States
ID NLM: 9504688
Informations de publication
Date de publication:
09 2020
09 2020
Historique:
entrez:
5
9
2020
pubmed:
6
9
2020
medline:
6
8
2021
Statut:
ppublish
Résumé
: Copper and zinc containing welding fumes are able to induce systemic inflammation in healthy subjects. In this study the no observed effect levels (NOEL) for welding fumes containing either copper or zinc were assessed.Fifteen healthy male volunteers participated in an exposure. Each subject was exposed to two different concentrations of both, copper and zinc containing welding fumes. Exposure was performed in the Aachen Workplace Simulation Lab.The NOEL was found at metal concentrations between 0.2 and 0.3 mg/m for copper and between 0.8 and 1.2 mg/m for zinc.The NOEL identified in this study was about a factor of 10 higher than the German workplace threshold limit values (TLV). However, TLV in other countries was in the same range or even higher than the NOEL indicating a considerable risk for workers.
Identifiants
pubmed: 32890210
doi: 10.1097/JOM.0000000000001946
pii: 00043764-202009000-00009
doi:
Substances chimiques
Air Pollutants, Occupational
0
Copper
789U1901C5
C-Reactive Protein
9007-41-4
Zinc
J41CSQ7QDS
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
718-723Références
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