Crystal structure of the periplasmic sensor domain of histidine kinase VbrK suggests indirect sensing of β-lactam antibiotics.

Anti-Bacterial Agents / chemistry Bacterial Proteins / chemistry Crystallography, X-Ray / methods Histidine Kinase / chemistry Periplasm / chemistry Protein Binding Vibrio parahaemolyticus / chemistry beta-Lactamases / chemistry beta-Lactams / chemistry
Histidine kinase Sensing domain Single wavelength anomalous dispersion Two component system Vibrio

Journal

Journal of structural biology
ISSN: 1095-8657
Titre abrégé: J Struct Biol
Pays: United States
ID NLM: 9011206

Informations de publication

Date de publication:
01 11 2020
Historique:
received: 12 07 2020
revised: 19 08 2020
accepted: 26 08 2020
pubmed: 6 9 2020
medline: 15 10 2021
entrez: 5 9 2020
Statut: ppublish

Résumé

Bacterial two-component regulatory systems (TCS) play important roles in sensing environmental stimuli and responding to them by regulating gene expression. VbrK/VbrR, a TCS in Vibrio parahaemolyticus, confers resistance to β-lactam antibiotics through activating a β-lactamase gene. Its periplasmic sensor domain was previously suggested to detect β-lactam antibiotics by direct binding. Here, we report a crystal structure of the periplasmic sensing domain of VbrK (VbrK

Identifiants

DOI: 10.1016/j.jsb.2020.107610 PMID: 32890780
pubmed: 32890780
pii: S1047-8477(20)30183-0
doi: 10.1016/j.jsb.2020.107610
pii:
doi:

Substances chimiques

Anti-Bacterial Agents 0
Bacterial Proteins 0
beta-Lactams 0
Histidine Kinase EC 2.7.13.1
beta-Lactamases EC 3.5.2.6

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

107610

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Auteurs

Boon Chong Goh (BC)

Antimicrobial Resistance Interdisciplinary Research Group, Singapore-MIT Alliance for Research and Technology Centre, 138602, Singapore; NTU Institute of Structural Biology, Nanyang Technological University, 636921, Singapore. Electronic address: boonchong@smart.mit.edu.

Yong Kang Chua (YK)

School of Biological Sciences, Nanyang Technological University, 637551, Singapore; Yong Loo Lin School of Medicine, National University of Singapore, 117456, Singapore.

Xinlei Qian (X)

Antimicrobial Resistance Interdisciplinary Research Group, Singapore-MIT Alliance for Research and Technology Centre, 138602, Singapore; NTU Institute of Structural Biology, Nanyang Technological University, 636921, Singapore; Life Sciences Institute, National University of Singapore, 117456, Singapore.

Jianqing Lin (J)

NTU Institute of Structural Biology, Nanyang Technological University, 636921, Singapore; School of Biological Sciences, Nanyang Technological University, 637551, Singapore; Singapore Immunology Network, Agency for Science, Technology and Research, 138648, Singapore.

Martin Savko (M)

Synchrotron SOLEIL, L'Orme des Merisiers, Saint-Aubin, BP 48, 91192 Gif-sur-Yvette, France.

Peter C Dedon (PC)

Antimicrobial Resistance Interdisciplinary Research Group, Singapore-MIT Alliance for Research and Technology Centre, 138602, Singapore; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Julien Lescar (J)

Antimicrobial Resistance Interdisciplinary Research Group, Singapore-MIT Alliance for Research and Technology Centre, 138602, Singapore; NTU Institute of Structural Biology, Nanyang Technological University, 636921, Singapore; School of Biological Sciences, Nanyang Technological University, 637551, Singapore. Electronic address: julien@ntu.edu.sg.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › Crystal structure of the periplasmic sensor...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines bactériennes › Crystal structure of the periplasmic sensor...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Cristallographie aux rayons X › Crystal structure of the periplasmic sensor...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Phosphotransferases › Phosphotransferases (Alcohol Group Acceptor) › Protein kinases › Histidine kinase › Crystal structure of the periplasmic sensor...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace extracellulaire › Périplasme › Crystal structure of the periplasmic sensor...
questionsmedicales.fr › Métabolisme › Liaison aux protéines › Crystal structure of the periplasmic sensor...
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Vibrionaceae › Vibrio › Vibrio parahaemolyticus › Crystal structure of the periplasmic sensor...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Amidohydrolases › bêta-Lactamases › Crystal structure of the periplasmic sensor...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › bêta-Lactames › Crystal structure of the periplasmic sensor...