The interplay between gut microbiota and autism spectrum disorders: A focus on immunological pathways.
ASD
Astrocyte
Gut microbiota
Gut-brain axis
Microglia
Neuroinflammation
Journal
Progress in neuro-psychopharmacology & biological psychiatry
ISSN: 1878-4216
Titre abrégé: Prog Neuropsychopharmacol Biol Psychiatry
Pays: England
ID NLM: 8211617
Informations de publication
Date de publication:
02 03 2021
02 03 2021
Historique:
received:
01
05
2020
revised:
21
08
2020
accepted:
30
08
2020
pubmed:
7
9
2020
medline:
1
1
2022
entrez:
6
9
2020
Statut:
ppublish
Résumé
Autism spectrum disorders (ASD) are a group of neurodevelopmental disorders characterized by impairments in social and cognitive activities, stereotypical and repetitive behaviors and restricted areas of interest. A remarkable proportion of ASD patients represent immune dysregulation as well as gastrointestinal complications. Hence, a novel concept has recently emerged, addressing the possible intercommunication between the brain, the immune system, the gut and its commensals. Here, we provide an overview of how gut microbes and their metabolites are associated with neurobehavioral features of ASD through various immunologic mechanisms. Moreover, we discuss the potential therapeutic options that could modify these features.
Identifiants
pubmed: 32891667
pii: S0278-5846(20)30407-3
doi: 10.1016/j.pnpbp.2020.110091
pii:
doi:
Substances chimiques
Prebiotics
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
110091Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.