Trypanosoma cruzi trans-sialidase induces STAT3 and ERK activation by prokineticin receptor 2 binding.
Animals
Extracellular Signal-Regulated MAP Kinases
/ metabolism
Ganglia, Spinal
/ cytology
Glycoproteins
/ chemistry
Male
Mice
Mice, Inbred C57BL
Mutagenesis, Site-Directed
NFATC Transcription Factors
/ metabolism
Neuraminidase
/ chemistry
Phosphorylation
/ drug effects
Protein Binding
Protein Domains
/ genetics
Protozoan Proteins
/ chemistry
Receptors, G-Protein-Coupled
/ genetics
Receptors, Peptide
/ genetics
Recombinant Proteins
/ biosynthesis
STAT3 Transcription Factor
/ metabolism
Signal Transduction
Trypanosoma cruzi
/ metabolism
Up-Regulation
/ drug effects
Kallmann syndrome
Prokineticin
Prokineticin receptor 2
Trypanosoma cruzi
signal transduction
Journal
Cell biochemistry and function
ISSN: 1099-0844
Titre abrégé: Cell Biochem Funct
Pays: England
ID NLM: 8305874
Informations de publication
Date de publication:
Mar 2021
Mar 2021
Historique:
received:
30
03
2020
revised:
15
07
2020
accepted:
01
08
2020
pubmed:
7
9
2020
medline:
7
7
2021
entrez:
6
9
2020
Statut:
ppublish
Résumé
Tc85, as other members of trans-sialidase family, is involved in Trypanosoma cruzi parasite adhesion to mammalian cells. Particularly, Tc85 acts through specific interactions with prokineticin receptor 2, a G-protein coupled receptor involved in diverse physiological and pathological processes. In this manuscript, through biochemical analyses, we demonstrated that LamG, a Tc85 domain, physically interacts with the prokineticin receptor 2. Moreover, expressing prokineticin receptor 1 and 2 we demonstrated that LamG specifically activates prokineticin receptor 2 through a strong coupling with G
Substances chimiques
Glycoproteins
0
NFATC Transcription Factors
0
PROKR1 protein, human
0
PROKR2 protein, human
0
Protozoan Proteins
0
Receptors, G-Protein-Coupled
0
Receptors, Peptide
0
Recombinant Proteins
0
STAT3 Transcription Factor
0
Extracellular Signal-Regulated MAP Kinases
EC 2.7.11.24
trans-sialidase
EC 3.2.1.-
Neuraminidase
EC 3.2.1.18
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
326-334Subventions
Organisme : Sapienza Università di Roma
ID : AR21816436367468
Informations de copyright
© 2020 John Wiley & Sons Ltd.
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