Novel oxygenation technique for hypothermic machine perfusion of liver grafts: Validation in porcine Donation after Cardiac Death (DCD) liver model.

Animals Biomarkers / metabolism Death Liver / metabolism Liver Transplantation Models, Animal Organ Preservation / methods Oxygen / administration & dosage Perfusion / methods Random Allocation Swine Tissue and Organ Procurement / methods
Ex vivo perfusion Hypothermic machine perfusion Hypothermic oxygenated machine perfusion Ischemia/reperfusion injury Liver graft preservation Liver transplantation

Journal

American journal of surgery
ISSN: 1879-1883
Titre abrégé: Am J Surg
Pays: United States
ID NLM: 0370473

Informations de publication

Date de publication:
11 2020
Historique:
received: 19 02 2020
revised: 29 04 2020
accepted: 26 06 2020
pubmed: 8 9 2020
medline: 5 1 2021
entrez: 7 9 2020
Statut: ppublish

Résumé

Hypothermic oxygenated machine perfusion improves outcomes in Liver Transplantation, but application is limited as O Porcine DCD livers were randomized to static cold storage (SCS, n = 8) or hypothermic machine perfusion (HMP). HMP was stratified into HMP-O "Pre-charge" achieves sustained tissue and perfusate pO "Pre-charge" is an effective technique, which allows portability and transport without an O

Sections du résumé

BACKGROUND
Hypothermic oxygenated machine perfusion improves outcomes in Liver Transplantation, but application is limited as O
METHODS
Porcine DCD livers were randomized to static cold storage (SCS, n = 8) or hypothermic machine perfusion (HMP). HMP was stratified into HMP-O
RESULTS
"Pre-charge" achieves sustained tissue and perfusate pO
CONCLUSIONS
"Pre-charge" is an effective technique, which allows portability and transport without an O

Identifiants

DOI: 10.1016/j.amjsurg.2020.06.072 PMID: 32892979
pubmed: 32892979
pii: S0002-9610(20)30426-8
doi: 10.1016/j.amjsurg.2020.06.072
pii:
doi:

Substances chimiques

Biomarkers 0
Oxygen S88TT14065

Types de publication

Journal Article Research Support, Non-U.S. Gov't Validation Study

Langues

eng

Sous-ensembles de citation

IM

Pagination

1270-1277

Subventions

Organisme : NIDDK NIH HHS
ID : K08 DK118187
Pays : United States

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Auteurs

Guergana G Panayotova (GG)

Department of Surgery, Division of Transplant and Hepatobiliary Surgery, Rutgers New Jersey Medical School, 185 South Orange Ave MSB G586, Newark, NJ, 07103, USA. Electronic address: gp353@njms.rutgers.edu.

Jesus Rosado (J)

Department of Surgery, Division of Transplant and Hepatobiliary Surgery, Rutgers New Jersey Medical School, 185 South Orange Ave MSB G586, Newark, NJ, 07103, USA.

Flavio Paterno (F)

Department of Surgery, Division of Transplant and Hepatobiliary Surgery, Rutgers New Jersey Medical School, 185 South Orange Ave MSB G586, Newark, NJ, 07103, USA.

Dayanand Deo (D)

New Jersey Sharing Network, 691 Central Avenue, New Providence, NJ, 07974, USA.

George Dikdan (G)

Department of Surgery, Division of Transplant and Hepatobiliary Surgery, Rutgers New Jersey Medical School, 185 South Orange Ave MSB G586, Newark, NJ, 07103, USA.

Matthew A McCarty (MA)

Department of Surgery, Division of Transplant and Hepatobiliary Surgery, Rutgers New Jersey Medical School, 185 South Orange Ave MSB G586, Newark, NJ, 07103, USA.

Ben Arrington (B)

Organ Recovery Systems, One Pierce Place, Suite 475W, Itasca, IL, 60143, USA.

Anthony Giudice (A)

Organ Recovery Systems, One Pierce Place, Suite 475W, Itasca, IL, 60143, USA.

Adam Fano (A)

Department of Surgery, Division of Transplant and Hepatobiliary Surgery, Rutgers New Jersey Medical School, 185 South Orange Ave MSB G586, Newark, NJ, 07103, USA.

Nehal Dhaduk (N)

Department of Surgery, Division of Transplant and Hepatobiliary Surgery, Rutgers New Jersey Medical School, 185 South Orange Ave MSB G586, Newark, NJ, 07103, USA.

Keri E Lunsford (KE)

Department of Surgery, Division of Transplant and Hepatobiliary Surgery, Rutgers New Jersey Medical School, 185 South Orange Ave MSB G586, Newark, NJ, 07103, USA.

Prakash Rao (P)

New Jersey Sharing Network, 691 Central Avenue, New Providence, NJ, 07974, USA.

James V Guarrera (JV)

Department of Surgery, Division of Transplant and Hepatobiliary Surgery, Rutgers New Jersey Medical School, 185 South Orange Ave MSB G586, Newark, NJ, 07103, USA. Electronic address: james.guarrera@njms.rutgers.edu.

Articles similaires

Evaluating the efficacy of telesurgery with dual console SSI Mantra Surgical Robotic System: experiment on animal model and clinical trials.

Sudhir Prem Srivastava, Vishwajyoti Pascual Srivastava, Avinesh Singh et al.
1.00
Robotic Surgical Procedures Animals Humans Telemedicine Models, Animal

Odour generalisation and detection dog training.

Lyn Caldicott, Thomas W Pike, Helen E Zulch et al.
1.00
Animals Odorants Dogs Generalization, Psychological Smell

Within-subject variation of C-reactive protein and high-sensitivity C-reactive protein: A systematic review and meta-analysis.

Alex Gough, Alice Sitch, Erica Ferris et al.
1.00
C-Reactive Protein Humans Biomarkers Inflammation

FBXO22 inhibits colitis and colorectal carcinogenesis by regulating the degradation of the S2448-phosphorylated form of mTOR.

Minle Li, Xuan Chen, Pengfei Qu et al.
1.00
Animals TOR Serine-Threonine Kinases Colorectal Neoplasms Colitis Mice

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Novel oxygenation technique for hypothermic...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Novel oxygenation technique for hypothermic...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Mort › Novel oxygenation technique for hypothermic...
questionsmedicales.fr › Système digestif › Foie › Novel oxygenation technique for hypothermic...
questionsmedicales.fr › Procédures de chirurgie opératoire › Transplantation › Transplantation de tissu › Transplantation hépatique › Novel oxygenation technique for hypothermic...
questionsmedicales.fr › Techniques d'investigation › Modèles animaux › Novel oxygenation technique for hypothermic...
questionsmedicales.fr › Techniques d'investigation › Conservation biologique › Conservation de tissu › Conservation d'organe › Novel oxygenation technique for hypothermic...
questionsmedicales.fr › Produits chimiques inorganiques › Gaz › Oxygène › Novel oxygenation technique for hypothermic...
questionsmedicales.fr › Techniques d'investigation › Perfusion › Novel oxygenation technique for hypothermic...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Méthodologie en recherche épidémiologique › Répartition aléatoire › Novel oxygenation technique for hypothermic...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Artiodactyla › Suidae › Novel oxygenation technique for hypothermic...
questionsmedicales.fr › Établissements, main d'oeuvre et services de soins de santé › Services de santé › Acquisition d'organes et de tissus › Novel oxygenation technique for hypothermic...