Paving the Road for RNA Therapeutics.

Drug Delivery Systems Nanoparticles Nucleic Acids RNA RNA, Small Interfering
RNA therapy cell-specific targeting drug delivery nanoparticles

Journal

Trends in pharmacological sciences
ISSN: 1873-3735
Titre abrégé: Trends Pharmacol Sci
Pays: England
ID NLM: 7906158

Informations de publication

Date de publication:
10 2020
Historique:
received: 18 02 2020
revised: 06 08 2020
accepted: 06 08 2020
pubmed: 8 9 2020
medline: 1 9 2021
entrez: 7 9 2020
Statut: ppublish

Résumé

Therapeutic RNA molecules possess high potential for treating medical conditions if they can successfully reach the target cell upon administration. However, unmodified RNA molecules are rapidly degraded and cleared from the circulation. In addition, their large size and negative charge complicates their passing through the cell membrane. The difficulty of RNA therapy, therefore, lies in the efficient intracellular delivery of intact RNA molecules to the tissue of interest without inducing adverse effects. Here, we outline the recent developments in therapeutic RNA delivery and discuss the wide potential in manipulating the function of cells with RNAs. The focus is not only on the variety of delivery strategies but also on the versatile nature of RNA and its wide applicability. This wide applicability is especially interesting when considering the modular nature of nucleic acids. An optimal delivery vehicle, therefore, can facilitate numerous clinical applications of RNA.

Identifiants

DOI: 10.1016/j.tips.2020.08.004 PMID: 32893005 PMC: PMC7470715
pubmed: 32893005
pii: S0165-6147(20)30185-1
doi: 10.1016/j.tips.2020.08.004
pmc: PMC7470715
pii:
doi:

Substances chimiques

Nucleic Acids 0
RNA, Small Interfering 0
RNA 63231-63-0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

755-775

Subventions

Organisme : European Research Council
ID : 647410
Pays : International

Informations de copyright

Copyright © 2020 Elsevier Ltd. All rights reserved.

Références

Nat Rev Drug Discov. 2017 Jan;16(1):19-34
pubmed: 27910877
BMB Rep. 2015 Mar;48(3):147-52
pubmed: 25081998
Wiley Interdiscip Rev RNA. 2013 Nov-Dec;4(6):737-49
pubmed: 23893949
Mol Ther Methods Clin Dev. 2018 Apr 10;9:330-346
pubmed: 30038937
Biomaterials. 2020 Mar;234:119711
pubmed: 31945616
Nat Rev Drug Discov. 2017 Mar;16(3):181-202
pubmed: 27807347
Clin Transl Sci. 2019 Mar;12(2):98-112
pubmed: 30706991
Nat Rev Neurol. 2018 Jan;14(1):9-21
pubmed: 29192260
Curr Gene Ther. 2019;19(3):172-196
pubmed: 31566126
Mol Ther. 2010 Jul;18(7):1357-64
pubmed: 20461061
N Engl J Med. 2020 Apr 16;382(16):1507-1519
pubmed: 32187462
Theranostics. 2018 Jul 01;8(15):4016-4032
pubmed: 30128033
Handb Exp Pharmacol. 2014;219:1-12
pubmed: 24292822
Vaccines (Basel). 2019 Sep 20;7(4):
pubmed: 31547081
Adv Drug Deliv Rev. 2020;159:364-376
pubmed: 32298783
Nucleic Acids Res. 2020 Jun 4;48(10):5235-5253
pubmed: 32356888
Ther Deliv. 2013 Jul;4(7):791-809
pubmed: 23883124
Adv Exp Med Biol. 2019;1185:119-124
pubmed: 31884599
Mol Ther Nucleic Acids. 2013 Dec 17;2:e139
pubmed: 24345865
Mol Ther Nucleic Acids. 2018 Jun 1;11:382-392
pubmed: 29858073
Biomacromolecules. 2018 Jun 11;19(6):2320-2329
pubmed: 29767505
Mol Ther Nucleic Acids. 2012 Sep 18;1:e46
pubmed: 23344238
Mol Immunol. 2018 Jul;99:124-133
pubmed: 29777999
Nature. 2019 Oct;574(7778):S10-S12
pubmed: 31619807
Nucleic Acid Ther. 2018 Jun;28(3):109-118
pubmed: 29792572
Front Genet. 2019 May 16;10:478
pubmed: 31156715
Oncogene. 2019 May;38(18):3446-3457
pubmed: 30643190
Biochem Biophys Res Commun. 2012 Oct 5;426(4):571-7
pubmed: 22982308
Nanomaterials (Basel). 2020 Feb 20;10(2):
pubmed: 32093140
Sci Rep. 2016 Jun 21;6:27697
pubmed: 27323850
ACS Chem Biol. 2012 Jul 20;7(7):1214-20
pubmed: 22512638
J Transl Med. 2019 Feb 22;17(1):54
pubmed: 30795778
Expert Opin Biol Ther. 2015;15(9):1337-48
pubmed: 26125492
Nucleic Acids Res. 2014 Jul;42(13):8796-807
pubmed: 24992960
Silence. 2012 Jan 09;3(1):1
pubmed: 22230293
Nat Rev Drug Discov. 2019 Feb;18(2):85-89
pubmed: 30710142
Artif Cells Nanomed Biotechnol. 2018 Mar;46(2):274-283
pubmed: 28423924
Nat Rev Drug Discov. 2017 Mar;16(3):203-222
pubmed: 28209991
Adv Drug Deliv Rev. 2020;154-155:176-186
pubmed: 32659256
Mol Ther. 2018 Feb 7;26(2):446-455
pubmed: 29275847
Mol Pharm. 2011 Dec 5;8(6):2193-203
pubmed: 21985606
J Am Chem Soc. 2018 Nov 28;140(47):16264-16274
pubmed: 30346764
Mol Med. 2016 Sep;22:258-270
pubmed: 27249008
Cells. 2020 Jan 07;9(1):
pubmed: 31936122
Nat Nanotechnol. 2018 Mar;13(3):214-219
pubmed: 29379205
Cell Rep. 2018 Feb 27;22(9):2227-2235
pubmed: 29490262
J Control Release. 2016 Sep 10;237:1-13
pubmed: 27369865
Mol Ther. 2019 Apr 10;27(4):785-793
pubmed: 30611663
Mol Cancer. 2010 Apr 12;9:75
pubmed: 20385023
Biomaterials. 2011 Jun;32(18):4306-16
pubmed: 21429576
Clin Immunol. 2017 Mar;176:122-130
pubmed: 28099879
Mol Ther Nucleic Acids. 2018 Sep 7;12:730-740
pubmed: 30114557
Chonnam Med J. 2020 May;56(2):87-93
pubmed: 32509554
Chem Biol Drug Des. 2017 Nov;90(5):665-678
pubmed: 28378934
Genome Med. 2017 Jun 27;9(1):60
pubmed: 28655327
Trends Biotechnol. 2018 Feb;36(2):173-185
pubmed: 29305085
Genes (Basel). 2019 Jan 29;10(2):
pubmed: 30699960
Mol Diagn Ther. 2020 Feb;24(1):61-68
pubmed: 31792921
Science. 1990 Mar 23;247(4949 Pt 1):1465-8
pubmed: 1690918
Mol Ther Nucleic Acids. 2014 Nov 18;3:e210
pubmed: 25405467
Mol Ther Nucleic Acids. 2012 Aug 14;1:e37
pubmed: 23344179
Proc Natl Acad Sci U S A. 2017 Jan 24;114(4):E448-E456
pubmed: 28069945
Nat Rev Genet. 2014 Aug;15(8):541-55
pubmed: 25022906
Small. 2017 Jul;13(27):
pubmed: 28544767
ACS Nano. 2015 Jul 28;9(7):6706-16
pubmed: 26042619
Nucleic Acid Ther. 2012 Aug;22(4):255-64
pubmed: 22913596
J Control Release. 2019 Nov 10;313:33-41
pubmed: 31634546
Theranostics. 2018 Feb 7;8(6):1575-1590
pubmed: 29556342
Int J Mol Sci. 2018 Nov 15;19(11):
pubmed: 30445702
Genes (Basel). 2018 Oct 31;9(11):
pubmed: 30384431
Nat Rev Drug Discov. 2018 May;17(5):301-302
pubmed: 29348682
Oncotarget. 2017 Feb 7;8(6):9375-9387
pubmed: 28030843
Gene Ther. 2011 Jul;18(7):702-8
pubmed: 21368901
Eur J Pharm Sci. 2013 Feb 14;48(3):416-27
pubmed: 23262059
Annu Rev Med. 2019 Jan 27;70:307-321
pubmed: 30691367
Oncogene. 2018 Jun;37(24):3216-3228
pubmed: 29511346
Biomaterials. 2015 Aug;59:77-87
pubmed: 25956853
Nat Rev Drug Discov. 2019 Jun;18(6):421-446
pubmed: 30846871
Theranostics. 2020 Jan 1;10(2):938-955
pubmed: 31903161
Pharmaceuticals (Basel). 2013 Feb 04;6(2):161-83
pubmed: 24275946
Nat Commun. 2018 Oct 29;9(1):4493
pubmed: 30374059
Gene Ther. 2014 Jul;21(7):709-14
pubmed: 24871580
Methods Mol Biol. 2008;434:205-19
pubmed: 18470647
J Drug Target. 2016 Nov;24(9):780-786
pubmed: 27030014
Mol Ther. 2017 Jul 5;25(7):1491-1500
pubmed: 28392163
BMC Neurol. 2017 Sep 11;17(1):181
pubmed: 28893208
Mol Pharm. 2018 Apr 2;15(4):1495-1504
pubmed: 29502423
Eur J Pharm Biopharm. 2019 Aug;141:37-50
pubmed: 31103742
Front Immunol. 2019 Jul 17;10:1586
pubmed: 31379819
J Biol Chem. 2002 Apr 12;277(15):12689-96
pubmed: 11821398
Science. 2012 Aug 17;337(6096):816-21
pubmed: 22745249
Nature. 2018 Aug;560(7718):291-292
pubmed: 30108348
Molecules. 2019 Feb 23;24(4):
pubmed: 30813407
Trends Mol Med. 2001 May;7(5):221-8
pubmed: 11325634
Adv Mater. 2020 Mar;32(12):e1906128
pubmed: 31999380
J Mater Chem B. 2016 Oct 21;4(39):6468-6474
pubmed: 32263456
Mol Ther. 2019 Apr 10;27(4):710-728
pubmed: 30846391
Ther Deliv. 2019 Mar;10(3):151-164
pubmed: 30909853
Front Physiol. 2018 Oct 09;9:1262
pubmed: 30356745
Proc Natl Acad Sci U S A. 2016 Jan 5;113(1):E16-22
pubmed: 26699502
Adv Drug Deliv Rev. 2016 Sep 1;104:93-109
pubmed: 26686832
Bioconjug Chem. 2019 Feb 20;30(2):366-383
pubmed: 30608140
Nat Chem Biol. 2018 Nov;14(11):1043-1050
pubmed: 30327560
Annu Rev Biomed Eng. 2006;8:377-402
pubmed: 16834561
Front Pharmacol. 2019 Apr 26;10:444
pubmed: 31105570
Front Immunol. 2019 Mar 27;10:594
pubmed: 30972078
J Control Release. 2015 Apr 10;203:1-15
pubmed: 25660205
Nanomaterials (Basel). 2017 Apr 05;7(4):
pubmed: 28379201
Mol Diagn Ther. 2020 Feb;24(1):49-59
pubmed: 31701435
Pharmacol Ther. 2019 Apr;196:91-104
pubmed: 30521885

Auteurs

Niels Dammes (N)

Laboratory of Precision NanoMedicine, Tel Aviv University, Tel Aviv 69978, Israel; School of Molecular Cell Biology and Biotechnology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel; Department of Materials Sciences and Engineering, Iby and Aladar Fleischman Faculty of Engineering, Tel Aviv University, Tel Aviv 69978, Israel; Center for Nanoscience and Nanotechnology, and Tel Aviv University, Tel Aviv 69978, Israel; Cancer Biology Research Center, Tel Aviv University, Tel Aviv 69978, Israel.

Dan Peer (D)

Laboratory of Precision NanoMedicine, Tel Aviv University, Tel Aviv 69978, Israel; School of Molecular Cell Biology and Biotechnology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel; Department of Materials Sciences and Engineering, Iby and Aladar Fleischman Faculty of Engineering, Tel Aviv University, Tel Aviv 69978, Israel; Center for Nanoscience and Nanotechnology, and Tel Aviv University, Tel Aviv 69978, Israel; Cancer Biology Research Center, Tel Aviv University, Tel Aviv 69978, Israel. Electronic address: peer@tauex.tau.ac.il.

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Classifications MeSH

questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Systèmes de délivrance de médicaments › Paving the Road for RNA Therapeutics.
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Nanostructures › Nanoparticules › Paving the Road for RNA Therapeutics.
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › Paving the Road for RNA Therapeutics.
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › Paving the Road for RNA Therapeutics.
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN non traduit › Petit ARN non traduit › Petit ARN interférent › Paving the Road for RNA Therapeutics.