Analysis of human neutrophil phenotypes as biomarker to monitor exercise-induced immune changes.
innate immune system
neutrophil
prolonged walking
repetitive exercise
Journal
Journal of leukocyte biology
ISSN: 1938-3673
Titre abrégé: J Leukoc Biol
Pays: England
ID NLM: 8405628
Informations de publication
Date de publication:
04 2021
04 2021
Historique:
revised:
14
08
2020
received:
09
07
2020
accepted:
22
08
2020
pubmed:
8
9
2020
medline:
5
5
2021
entrez:
7
9
2020
Statut:
ppublish
Résumé
The amplitude of the innate immune response reflects the degree of physiological stress imposed by exercise load. An optimal balance of exercise intensity and duration is essential for a balanced immune system and reduces the risk of dysfunction of the immune system. Therefore, it is hypothesized that neutrophils, as key players in the innate immune system, can be used as biomarker in detecting overtraining. The aim was to monitor the state of the innate immune system by phenotyping neutrophils during consecutive bouts of prolonged exercise. Study subjects were recruited from a cohort of walkers participating in a walking event on 3 consecutive days. Participants with immune deficiencies were excluded. Questionnaires to determine the physiological status of the participants were completed. Analysis of neutrophil receptor expression was done by a point-of-care fully automated flow cytometer. A total of 45 participants were recruited, of whom 39 participants were included for data analysis. Study participants had a median age of 64 (58-70) years. The absolute numbers CD16
Identifiants
pubmed: 32893357
doi: 10.1002/JLB.5A0820-436R
pmc: PMC8048637
doi:
Substances chimiques
Antigens, CD
0
Biomarkers
0
Types de publication
Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
833-842Informations de copyright
© 2020 The Authors. Journal of Leukocyte Biology published by Wiley Periodicals LLC on behalf of Society for Leukocyte Biology.
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