Impact and consequences of intensive chemotherapy on intestinal barrier and microbiota in acute myeloid leukemia: the role of mucosal strengthening.
Adult
Aged
Animals
Antineoplastic Combined Chemotherapy Protocols
/ adverse effects
Dysbiosis
/ chemically induced
Fatty Acids, Volatile
/ analysis
Feces
/ chemistry
Female
Gastrointestinal Microbiome
/ drug effects
Humans
Induction Chemotherapy
/ adverse effects
Intestinal Mucosa
/ drug effects
Leukemia, Myeloid, Acute
/ drug therapy
Male
Mice
Mice, Transgenic
Middle Aged
Mucus
/ metabolism
Intestinal barrier
acute leukemia
chemotherapy
microbiota
mucus
Journal
Gut microbes
ISSN: 1949-0984
Titre abrégé: Gut Microbes
Pays: United States
ID NLM: 101495343
Informations de publication
Date de publication:
09 11 2020
09 11 2020
Historique:
entrez:
7
9
2020
pubmed:
8
9
2020
medline:
1
10
2021
Statut:
ppublish
Résumé
Induction chemotherapy (7 + 3 regimen) remains the gold standard for patients with acute myeloid leukemia (AML) but is responsible for gut damage leading to several complications such as bloodstream infection (BSI). We aimed to investigate the impact of induction chemotherapy on the intestinal barrier of patients with AML and in wild-type mice. Next, we assessed the potential benefit of strengthening the mucosal barrier in transgenic mice releasing a recombinant protein able to reinforce the mucus layer (Tg222). In patients, we observed a decrease of plasma citrulline, which is a marker of the functional enterocyte mass, of short-chain fatty acids and of fecal bacterial load, except for
Identifiants
pubmed: 32893715
doi: 10.1080/19490976.2020.1800897
pmc: PMC7524297
doi:
Substances chimiques
Fatty Acids, Volatile
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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