Critical review of multimorbidity outcome measures suitable for low-income and middle-income country settings: perspectives from the Global Alliance for Chronic Diseases (GACD) researchers.
clinical trials
primary care
public health
statistics & research methods
Journal
BMJ open
ISSN: 2044-6055
Titre abrégé: BMJ Open
Pays: England
ID NLM: 101552874
Informations de publication
Date de publication:
06 09 2020
06 09 2020
Historique:
entrez:
8
9
2020
pubmed:
9
9
2020
medline:
15
5
2021
Statut:
epublish
Résumé
There is growing recognition around the importance of multimorbidity in low-income and middle-income country (LMIC) settings, and specifically the need for pragmatic intervention studies to reduce the risk of developing multimorbidity, and of mitigating the complications and progression of multimorbidity in LMICs. One of many challenges in completing such research has been the selection of appropriate outcomes measures. A 2018 Delphi exercise to develop a core-outcome set for multimorbidity research did not specifically address the challenges of multimorbidity in LMICs where the global burden is greatest, patterns of disease often differ and health systems are frequently fragmented. We, therefore, aimed to summarise and critically review outcome measures suitable for studies investigating mitigation of multimorbidity in LMIC settings. LMIC. People with multimorbidity. Identification of all outcome measures. We present a critical review of outcome measures across eight domains: mortality, quality of life, function, health economics, healthcare access and utilisation, treatment burden, measures of 'Healthy Living' and self-efficacy and social functioning. Studies in multimorbidity are necessarily diverse and thus different outcome measures will be appropriate for different study designs. Presenting the diversity of outcome measures across domains should provide a useful summary for researchers, encourage the use of multiple domains in multimorbidity research, and provoke debate and progress in the field.
Identifiants
pubmed: 32895277
pii: bmjopen-2020-037079
doi: 10.1136/bmjopen-2020-037079
pmc: PMC7478040
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e037079Subventions
Organisme : Medical Research Council
ID : MR/P008984/1
Pays : United Kingdom
Investigateurs
Ricardo Araya
(R)
Kirsten Bobrow
(K)
Niels H Chavannes
(NH)
F Xavier Gómez-Olivé
(F)
Shabbar Jaffar
(S)
Bruce J Kirenga
(BJ)
Rianne M J J van der Kleij
(RMJJV)
Muralidhar M Kulkarni
(MM)
Laura Loli-Dano
(L)
Patricio Lopez-Jaramillo
(P)
Shane Norris
(S)
Josefien van Olmen
(JV)
Gary Parker
(G)
Trishul Siddharthan
(T)
Kamran Siddiqi
(K)
Najma Siddiqi
(N)
Antigona C Trofor
(AC)
Informations de copyright
© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
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