Catheter-integrated soft multilayer electronic arrays for multiplexed sensing and actuation during cardiac surgery.
Journal
Nature biomedical engineering
ISSN: 2157-846X
Titre abrégé: Nat Biomed Eng
Pays: England
ID NLM: 101696896
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
26
03
2020
accepted:
17
07
2020
pubmed:
9
9
2020
medline:
31
12
2020
entrez:
8
9
2020
Statut:
ppublish
Résumé
The rigidity and relatively primitive modes of operation of catheters equipped with sensing or actuation elements impede their conformal contact with soft-tissue surfaces, limit the scope of their uses, lengthen surgical times and increase the need for advanced surgical skills. Here, we report materials, device designs and fabrication approaches for integrating advanced electronic functionality with catheters for minimally invasive forms of cardiac surgery. By using multiphysics modelling, plastic heart models and Langendorff animal and human hearts, we show that soft electronic arrays in multilayer configurations on endocardial balloon catheters can establish conformal contact with curved tissue surfaces, support high-density spatiotemporal mapping of temperature, pressure and electrophysiological parameters and allow for programmable electrical stimulation, radiofrequency ablation and irreversible electroporation. Integrating multimodal and multiplexing capabilities into minimally invasive surgical instruments may improve surgical performance and patient outcomes.
Identifiants
pubmed: 32895515
doi: 10.1038/s41551-020-00604-w
pii: 10.1038/s41551-020-00604-w
pmc: PMC8021456
mid: NIHMS1684044
doi:
Banques de données
figshare
['10.6084/m9.figshare.12631835']
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
997-1009Subventions
Organisme : NHLBI NIH HHS
ID : K99 HL148523
Pays : United States
Organisme : NIGMS NIH HHS
ID : P41 GM103545
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL141470
Pays : United States
Organisme : NIGMS NIH HHS
ID : R24 GM136986
Pays : United States
Commentaires et corrections
Type : CommentIn
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