Antibacterial activity and mechanism of three isomeric terpineols of Cinnamomum longepaniculatum leaf oil.
Journal
Folia microbiologica
ISSN: 1874-9356
Titre abrégé: Folia Microbiol (Praha)
Pays: United States
ID NLM: 0376757
Informations de publication
Date de publication:
Feb 2021
Feb 2021
Historique:
received:
25
03
2020
accepted:
30
08
2020
pubmed:
9
9
2020
medline:
30
7
2021
entrez:
8
9
2020
Statut:
ppublish
Résumé
α-Terpineol, terpinen-4-ol, and δ-terpineol, isomers of terpineol, are among the compounds that give Cinnamomum longepaniculatum leaf oil its distinguished pleasant smell. The objective of this study was to evaluate the antimicrobial activity of these three isomeric terpineols. The determination of antibacterial activity was based on the minimum inhibition concentration (MIC) and minimum bactericide concentration (MBC). Changes in time-kill curve, alkaline phosphatase (AKP), UV-absorbing material, membrane potential, and scanning electron microscopy (SEM) were measured to elucidate the possible antimicrobial mechanism. α-Terpineol, terpinen-4-ol, and δ-terpineol demonstrated good inhibitory effects against several gram-negative bacteria, particularly Shigella flexneri. MIC and MBC of α-terpineol and terpinen-4-ol were similar (0.766 mg/mL and 1.531 mg/mL, respectively) for S. flexneri, while the MIC and MBC values of δ-terpineol were 0.780 mg/mL and 3.125 mg/mL, respectively. Time-kill curves showed that the antibacterial activities of the tested compounds were in a concentration-dependent manner. Release of nucleic acids and proteins along with a decrease in membrane potential proved that α-terpineol, terpinen-4-ol, and δ-terpineol could increase the membrane permeability of Shigella flexneri. Additionally, the release of AKP suggested that the cell wall was destroyed. SEM analysis further confirmed that S. flexneri cell membranes were damaged by α-terpineol, terpinen-4-ol, and δ-terpineol. Our research suggests that these three isomeric terpineols have the potential of being used as natural antibacterial agents by destroying the cell membrane and wall, resulting in cell death. However, the specific antibacterial activity differences need further investigation.
Identifiants
pubmed: 32895862
doi: 10.1007/s12223-020-00818-0
pii: 10.1007/s12223-020-00818-0
doi:
Substances chimiques
Anti-Bacterial Agents
0
Oils, Volatile
0
Terpenes
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
59-67Subventions
Organisme : National Science Foundation of China
ID : No. 31700025
Organisme : Sichuan Science and Technology Program
ID : No. 2017JY0316
Organisme : Sichuan Science and Technology Program
ID : No. 2019YFN0029
Organisme : Research team Project of Yibin University
ID : No. 18PTDJ0011
Organisme : Innovation Research team of Yibin University
ID : No. 2017TD01
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