The Anionic Phospholipids of Bovine Pulmonary Surfactant.
Dipalmitoyl phosphatidylcholine
Dipalmitoyl phosphatidylglycerol
Electrospray mass spectrometry
Lung
Phosphatidylglycerol
Phosphatidylinositol
Journal
Lipids
ISSN: 1558-9307
Titre abrégé: Lipids
Pays: United States
ID NLM: 0060450
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
12
05
2020
revised:
18
06
2020
accepted:
14
07
2020
pubmed:
9
9
2020
medline:
28
9
2021
entrez:
8
9
2020
Statut:
ppublish
Résumé
The only known compositional change in the phospholipids (PL) of pulmonary surfactant in response to a physiologic stimulus occurs around the time of birth. In most species, the predominant anionic PL changes from phosphatidylinositol (PtdIns) to phosphatidylglycerol (PtdGro). Because prior studies have shown that the change in the headgroup itself is functionally insignificant, we tested the hypothesis that the PtdIns and PtdGro contain different diacyl pairs. Experiments used electrospray-ionization mass spectrometry to determine the molecular species in PtdIns, PtdGro, and phosphatidylcholine (PtdCho) in surfactant from newborn calves and cows. The profiles for the two anionic PL were distinct. The PtdIns contained long, unsaturated fatty acid chains and no disaturated species. The PtdGro more closely resembled the profile from PtdCho. For each headgroup, the molecular species for calf and cow were similar. The differences between the two anionic PL indicate that the switch from PtdIns to PtdGro during maturation involves more than simple substitution of the headgroup, and suggest that the functional significance of the shift may reflect the different pool of diacyl pairs.
Substances chimiques
Anions
0
Phospholipids
0
Pulmonary Surfactants
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
49-57Informations de copyright
© 2020 AOCS.
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