Structural Requirements for Uptake of Diphenhydramine Analogs into hCMEC/D3 Cells Via the Proton-Coupled Organic Cation Antiporter.

Antiporters / metabolism Biological Transport Blood-Brain Barrier / metabolism Cations Diphenhydramine Humans Organic Cation Transport Proteins / metabolism Protons
Blood-brain barrier Diphenhydramine analogs Membrane transport Proton-coupled organic cation antiporter Transporter hCMEC/D3 cells

Journal

Journal of pharmaceutical sciences
ISSN: 1520-6017
Titre abrégé: J Pharm Sci
Pays: United States
ID NLM: 2985195R

Informations de publication

Date de publication:
01 2021
Historique:
received: 22 06 2020
revised: 27 08 2020
accepted: 01 09 2020
pubmed: 9 9 2020
medline: 22 6 2021
entrez: 8 9 2020
Statut: ppublish

Résumé

There is increasing evidence that a proton-coupled organic cation (H

Identifiants

DOI: 10.1016/j.xphs.2020.09.001 PMID: 32898521
pubmed: 32898521
pii: S0022-3549(20)30494-9
doi: 10.1016/j.xphs.2020.09.001
pii:
doi:

Substances chimiques

Antiporters 0
Cations 0
Organic Cation Transport Proteins 0
Protons 0
Diphenhydramine 8GTS82S83M

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

397-403

Informations de copyright

Copyright © 2020 American Pharmacists Association®. Published by Elsevier Inc. All rights reserved.

Auteurs

Yuma Tega (Y)

Laboratory of Drug Disposition and Pharmacokinetics, Faculty of Pharma-Sciences, Teikyo University, 2-11-1 Kaga, Itabashi, Tokyo 173-8605, Japan.

Hidetsugu Tabata (H)

Laboratory of Medicinal Chemistry, Faculty of Pharma-Sciences, Teikyo University, 2-11-1 Kaga, Itabashi, Tokyo 173-8605, Japan.

Toshiki Kurosawa (T)

Laboratory of Drug Disposition and Pharmacokinetics, Faculty of Pharma-Sciences, Teikyo University, 2-11-1 Kaga, Itabashi, Tokyo 173-8605, Japan.

Atsushi Kitamura (A)

Laboratory of Drug Disposition and Pharmacokinetics, Faculty of Pharma-Sciences, Teikyo University, 2-11-1 Kaga, Itabashi, Tokyo 173-8605, Japan.

Fumio Itagaki (F)

Laboratory of Clinical Pharmaceutics, Faculty of Pharma-Sciences, Teikyo University, 2-11-1 Kaga, Itabashi, Tokyo 173-8605, Japan.

Tetsuta Oshitari (T)

Laboratory of Medicinal Chemistry, Faculty of Pharma-Sciences, Teikyo University, 2-11-1 Kaga, Itabashi, Tokyo 173-8605, Japan.

Yoshiharu Deguchi (Y)

Laboratory of Drug Disposition and Pharmacokinetics, Faculty of Pharma-Sciences, Teikyo University, 2-11-1 Kaga, Itabashi, Tokyo 173-8605, Japan. Electronic address: deguchi@pharm.teikyo-u.ac.jp.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Pompes ioniques › Antiports › Structural Requirements for Uptake of...
questionsmedicales.fr › Métabolisme › Transport biologique › Structural Requirements for Uptake of...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Barrière hémato-encéphalique › Structural Requirements for Uptake of...
questionsmedicales.fr › Produits chimiques inorganiques › Électrolytes › Ions › Cations › Structural Requirements for Uptake of...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Composés benzhydryliques › Diphénhydramine › Structural Requirements for Uptake of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Structural Requirements for Uptake of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Protéines transporteurs de solutés › Transporteurs de cations organiques › Structural Requirements for Uptake of...
questionsmedicales.fr › Phénomènes physiques › Particules élémentaires › Nucléons › Protons › Structural Requirements for Uptake of...