Dose-averaged linear energy transfer per se does not correlate with late rectal complications in carbon-ion radiotherapy.

Carbon Humans Linear Energy Transfer Proton Therapy Relative Biological Effectiveness Retrospective Studies
Carbon-ion radiotherapy Linear energy transfer Relative biological effectiveness

Journal

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
ISSN: 1879-0887
Titre abrégé: Radiother Oncol
Pays: Ireland
ID NLM: 8407192

Informations de publication

Date de publication:
12 2020
Historique:
received: 22 02 2020
revised: 28 08 2020
accepted: 31 08 2020
pubmed: 9 9 2020
medline: 15 4 2021
entrez: 8 9 2020
Statut: ppublish

Résumé

Several studies have focused on increasing the linear energy transfer (LET) within tumours to achieve higher biological effects in carbon-ion radiotherapy (C-ion RT). However, it remains unclear whether LET affects late complications. We assessed whether physical dose and LET distribution can be specific factors for late rectal complications in C-ion RT. Overall, 134 patients with uterine carcinomas were registered and retrospectively analysed. Of 134 patients, 132 who were followed up for >6 months were enrolled. The correlations between the relative biological effectiveness (RBE)-weighted dose based on the Kanai model (the ostensible "clinical dose"), dose-averaged LET (LETd), or physical dose and rectal complications were evaluated. Rectal complications were graded according to the Radiation Therapy Oncology Group/European Organization for Research and Treatment of Cancer criteria. Nine patients developed grade 3 or 4 late rectal complications. Linear regression analysis found that D We demonstrated that severe rectal toxicities were related to the rectal D

Sections du résumé

BACKGROUND AND PURPOSE
Several studies have focused on increasing the linear energy transfer (LET) within tumours to achieve higher biological effects in carbon-ion radiotherapy (C-ion RT). However, it remains unclear whether LET affects late complications. We assessed whether physical dose and LET distribution can be specific factors for late rectal complications in C-ion RT.
MATERIALS AND METHODS
Overall, 134 patients with uterine carcinomas were registered and retrospectively analysed. Of 134 patients, 132 who were followed up for >6 months were enrolled. The correlations between the relative biological effectiveness (RBE)-weighted dose based on the Kanai model (the ostensible "clinical dose"), dose-averaged LET (LETd), or physical dose and rectal complications were evaluated. Rectal complications were graded according to the Radiation Therapy Oncology Group/European Organization for Research and Treatment of Cancer criteria.
RESULTS
Nine patients developed grade 3 or 4 late rectal complications. Linear regression analysis found that D
CONCLUSION
We demonstrated that severe rectal toxicities were related to the rectal D

Identifiants

DOI: 10.1016/j.radonc.2020.08.029 PMID: 32898559
pubmed: 32898559
pii: S0167-8140(20)30758-1
doi: 10.1016/j.radonc.2020.08.029
pii:
doi:

Substances chimiques

Carbon 7440-44-0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

272-278

Informations de copyright

Copyright © 2020 The Author(s). Published by Elsevier B.V. All rights reserved.

Auteurs

Noriyuki Okonogi (N)

QST Hospital, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan. Electronic address: okonogi.noriyuki@qst.go.jp.

Shinnosuke Matsumoto (S)

Department of Accelerator and Medical Physics, National Institute of Radiological Sciences, Quantum Medical Science Directorate, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan. Electronic address: matsumoto.shinnosuke@qst.go.jp.

Mai Fukahori (M)

Incident and Emergency Centre, Department of Nuclear Safety and Security, International Atomic Energy Agency, Vienna, Austria. Electronic address: m.fukahori@iaea.org.

Wataru Furuichi (W)

Accelerator Engineering Corporation, Chiba, Japan. Electronic address: furuichi.wataru@qst.go.jp.

Taku Inaniwa (T)

Department of Accelerator and Medical Physics, National Institute of Radiological Sciences, Quantum Medical Science Directorate, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan. Electronic address: inaniwa.taku@qst.go.jp.

Naruhiro Matsufuji (N)

Department of Accelerator and Medical Physics, National Institute of Radiological Sciences, Quantum Medical Science Directorate, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan. Electronic address: matsufuji.naruhiro@qst.go.jp.

Reiko Imai (R)

QST Hospital, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan. Electronic address: imai.reiko@qst.go.jp.

Shigeru Yamada (S)

QST Hospital, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan. Electronic address: yamada.shigeru@qst.go.jp.

Nobuyuki Kanematsu (N)

Department of Accelerator and Medical Physics, National Institute of Radiological Sciences, Quantum Medical Science Directorate, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan. Electronic address: kanematsu.nobuyuki@qst.go.jp.

Hiroshi Tsuji (H)

QST Hospital, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan. Electronic address: tsuji.hiroshi@qst.go.jp.

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Classifications MeSH

questionsmedicales.fr › Produits chimiques inorganiques › Éléments › Carbone › Dose-averaged linear energy transfer per se...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Dose-averaged linear energy transfer per se...
questionsmedicales.fr › Phénomènes chimiques › Transfert d'énergie › Transfert linéique d'énergie › Dose-averaged linear energy transfer per se...
questionsmedicales.fr › Thérapeutique › Radiothérapie › Radiothérapie par ions lourds › Protonthérapie › Dose-averaged linear energy transfer per se...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Hygiène radiologique › Dose de rayonnement › Efficacité biologique relative › Dose-averaged linear energy transfer per se...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études rétrospectives › Dose-averaged linear energy transfer per se...