2-substituted benzothiazoles as antiproliferative agents: Novel insights on structure-activity relationships.
Anti-cancer agents
Benzothiazole
Kinase inhibitors
Molecular hybridization
Structure-activity relationships
Journal
European journal of medicinal chemistry
ISSN: 1768-3254
Titre abrégé: Eur J Med Chem
Pays: France
ID NLM: 0420510
Informations de publication
Date de publication:
01 Dec 2020
01 Dec 2020
Historique:
received:
02
07
2020
revised:
05
08
2020
accepted:
15
08
2020
pubmed:
9
9
2020
medline:
20
4
2021
entrez:
8
9
2020
Statut:
ppublish
Résumé
Given the wide spectrum of biological activities, benzothiazoles represent privileged scaffolds in medicinal chemistry, useful in drug discovery programs to modulate biological activities of lead compounds. A large body of knowledge about benzothiazoles has been reported in scientific literature, describing their antimicrobial, anticonvulsant, neuroprotective, anti-inflammatory, and antiproliferative effects. This review summarizes the results obtained in the structure-activity relationship studies on antiproliferative benzothiazoles, focusing on 2-substituted derivatives and on mechanism of action responsible for the antitumor effects of this class of compounds.
Identifiants
pubmed: 32898763
pii: S0223-5234(20)30734-0
doi: 10.1016/j.ejmech.2020.112762
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Benzothiazoles
0
benzothiazole
G5BW2593EP
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
112762Informations de copyright
Copyright © 2020 Elsevier Masson SAS. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.